Pharmacology Antibiotics Quiz
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Questions and Answers

What type of bacteria does Metronidazole primarily target?

  • Acid-fast bacteria
  • Anaerobic bacteria (correct)
  • Aerobic bacteria
  • Gram-negative bacteria

Which of the following characteristics apply to Rifampicin?

  • It is effective in neutral pH environments
  • It is hepatotoxic (correct)
  • It is bacteriostatic
  • It primarily targets aerobic bacteria

Which medications are included in the category of RNA synthesis inhibitors?

  • Metronidazole
  • Rifampicin (correct)
  • Moxifloxacin
  • Trimethoprim

What is a known effect of Rifampicin on other drugs?

<p>It reduces their efficacy (C)</p> Signup and view all the answers

Which of the following organisms is Metronidazole used to treat infections caused by?

<p>Clostridium (D)</p> Signup and view all the answers

What type of antibiotics are Trimethoprim and Sulfonamides classified as?

<p>Bacteriocidal (C)</p> Signup and view all the answers

Which of the following bacteria is not primarily targeted by Metronidazole?

<p>Pseudomonas (A)</p> Signup and view all the answers

What is one of the specificities of Rifampicin?

<p>It has activity in an acidic intracellular environment (C)</p> Signup and view all the answers

Which of the following characteristics define microaerophiles?

<p>Need oxygen but are poisoned by high concentrations of it (C)</p> Signup and view all the answers

What is a distinctive feature of aerotolerant anaerobes?

<p>Use fermentation to produce ATP and are not poisoned by oxygen (A)</p> Signup and view all the answers

Which family is characterized by being oxidase positive?

<p>Pseudomonadaceae (C)</p> Signup and view all the answers

Which type of mastitis is detectable only through increased somatic cell count (SCC) and decreased milk production?

<p>Subclinical mastitis (A)</p> Signup and view all the answers

In the context of bacterial classification, which of the following bacteria is indole positive?

<p>Escherichia coli (A)</p> Signup and view all the answers

What symptoms are indicative of severe clinical mastitis?

<p>Systemic symptoms such as fever and loss of appetite (B)</p> Signup and view all the answers

Which of the following bacteria is known to produce hydrogen sulfide (H2S)?

<p>Proteus spp. (C)</p> Signup and view all the answers

What is a common factor found in both physical trauma and pathogenic microorganisms regarding their role in mastitis?

<p>They can cause mastitis by affecting udder health (A)</p> Signup and view all the answers

Which class of antibiotics is characterized by the -penem suffix?

<p>Beta-lactam antibiotics (A)</p> Signup and view all the answers

Which bacteria are known to produce beta-lactamase?

<p>Klebsiella (A)</p> Signup and view all the answers

What is a major restriction in the use of carbapenems?

<p>They are primarily used for multidrug resistant strains (D)</p> Signup and view all the answers

Which of the following is a beta-lactamase inhibitor?

<p>Clavulanic acid (D)</p> Signup and view all the answers

Vancomycin is primarily used to target which type of bacteria?

<p>Gram-positive bacteria (A)</p> Signup and view all the answers

What syndrome is often associated with hypersensitivity reactions to beta-lactam antibiotics?

<p>Hemolytic anemia (B)</p> Signup and view all the answers

Which of the following bacteria is NOT commonly associated with beta-lactamase production?

<p>Bacillus cereus (D)</p> Signup and view all the answers

Which property is NOT characteristic of beta-lactamase inhibitors?

<p>They are always utilized alone without beta-lactams (A)</p> Signup and view all the answers

Which culture medium is NOT used for diagnosing Melitensis?

<p>Nutrient Broth (B)</p> Signup and view all the answers

What indicates a positive result in the STAT serology test for Melitensis?

<p>Titers greater than 1:160 (D)</p> Signup and view all the answers

Which of the following is a limitation of the BBAT serology test?

<p>Can yield false negatives due to the prozone phenomenon (A)</p> Signup and view all the answers

What is the primary use of the Brucellin Skin Test?

<p>Screening unvaccinated herds in ruminants (B)</p> Signup and view all the answers

Which method is considered one of the most common serologic methods for diagnosing Melitensis?

<p>Competitive ELISA (B)</p> Signup and view all the answers

What is the significance of a titer of 1:160 in serological testing for Melitensis?

<p>Denotes presence of IgM or IgG antibodies (A)</p> Signup and view all the answers

At what temperature range should cultures for Melitensis be incubated?

<p>25-42°C (B)</p> Signup and view all the answers

Which of the following tests requires confirmatory diagnosis if the result is positive?

<p>Rose Bengal Agglutination Test (A)</p> Signup and view all the answers

What is a common characteristic of lesions caused by aureus infection?

<p>Presence of necrosis and ulceration in the duct epithelium (B)</p> Signup and view all the answers

Which treatment is appropriate for mild cases of mastitis caused by aureus?

<p>Intramammary antibiotics for 5-7 days (D)</p> Signup and view all the answers

What additional therapy is recommended for moderate cases of mastitis?

<p>Supportive therapy with IV isotonics (A)</p> Signup and view all the answers

Which antibiotic is specifically noted for use in severe cases of mastitis?

<p>Clavulanic acid potentiated amoxicillin (D)</p> Signup and view all the answers

What is indicated by an increase in somatic cell count (SCC) during the early stages of Streptococcus agalactiae mastitis?

<p>Early stage of infection (D)</p> Signup and view all the answers

What is a possible clinical sign of mastitis associated with Streptococcus agalactiae in older cattle during early lactation?

<p>High bacterial count and marked reduction in milk production (A)</p> Signup and view all the answers

What are the consequences of untreated severe mastitis that shows signs of cold and blue/black discoloration?

<p>Potential requirement for mastectomy (C)</p> Signup and view all the answers

Which of the following features characterizes the presence of fibrosis and sclerosis in the udder due to chronic mastitis?

<p>Significant scarring and tissue hardening (A)</p> Signup and view all the answers

What could be indicated by the presence of proteinaceous material in the lumen of alveoli during microscopic examination?

<p>Active inflammation and infection (D)</p> Signup and view all the answers

What factor limits the somatic cell count for Swiss, EU, and USA standards of milk quality?

<p>Specific SCC limits vary by region: Swiss 350, EU 400, USA 500 (A)</p> Signup and view all the answers

What is one of the primary entry routes for pathogens in males?

<p>Testis (A)</p> Signup and view all the answers

What is a characteristic of female reproductive tract disorders associated with infection?

<p>Frequently results in abortions (D)</p> Signup and view all the answers

Which of the following is NOT a lesion associated with males infected with the disease?

<p>Tenosynovitis (C)</p> Signup and view all the answers

How do pathogens typically spread systemically in females after initial entry?

<p>Through lymphatic system (D)</p> Signup and view all the answers

Which lab test is primarily used for culture detection of the bacteria in the acute stage?

<p>Culture (D)</p> Signup and view all the answers

What is a common manifestation of joint disorders in infected individuals?

<p>Bursitis (C)</p> Signup and view all the answers

Which of the following is indicative of an acute infection in males?

<p>Inflammation of seminal vesicles (C)</p> Signup and view all the answers

What preventative measure is recommended when endemic issues are present?

<p>Vaccine administration (D)</p> Signup and view all the answers

Which of the following symptoms is associated with weak newborns due to infections?

<p>Lochia (A)</p> Signup and view all the answers

What is one of the diagnosable lesions observed in the uterus of infected females?

<p>Hyperemia + Edema (A)</p> Signup and view all the answers

What is a potential consequence of bacteremia in pregnant females?

<p>Foetal abortion (A)</p> Signup and view all the answers

Which method is least valuable for diagnosing the bacteria in chronic cases?

<p>Culture (B)</p> Signup and view all the answers

What can happen to the liver in chronic cases of the infection?

<p>Increased liver volume and necrosis (D)</p> Signup and view all the answers

Flashcards

Microaerophiles

Bacteria that require oxygen to survive but are harmed by high concentrations of it.

Aerotolerant Anaerobes

Bacteria that can survive without oxygen but don't need it. They make energy through fermentation.

Catalase

An enzyme that breaks down hydrogen peroxide.

Oxidase

An enzyme that breaks down cytochrome c.

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Hydrogen Sulfide (H2S)

A gas produced by some bacteria during metabolism, often associated with fecal contamination.

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Indole

A breakdown product of tryptophan, used for bacterial identification

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Mastitis

Inflammation of the mammary gland, often caused by bacterial infections.

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Subclinical Mastitis

Mastitis that shows no visible signs, but can be detected through elevated somatic cell count and reduced milk production.

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Metronidazole

A bactericidal antibiotic that targets anaerobic bacteria such as Clostridium and Fusobacterium. It also has antiparasitic activity against protozoa like Giardia and Trichomonas. Metronidazole is used to treat Pseudomembranous colitis, often associated with macrolide and lincosamide antibiotics. Available in oral, injectable, and topical forms.

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Rifampicin

A bactericidal antibiotic that inhibits RNA synthesis. It is effective against various bacteria including Staphylococcus, Mycobacterium, Legionella, Listeria, Haemophilus, and Brucellosis in horses. Refampicin is known for its hepatotoxicity and its activity in acidic intracellular environments. It also increases the metabolism of many other drugs, decreasing their effectiveness.

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Trimethoprim + Sulfonamides

A combination of two drugs, Trimethoprim and Sulfonamides, acting together to inhibit folic acid synthesis. This mechanism targets bacteria like Bordetella and E. coli, resulting in bactericidal activity.

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Metronidazole: Bovine Foot Rot

Bactericidal antibiotic that targets anaerobic bacteria. It is effective against Clostridium and Fusobacterium. Specifically targets anaerobic bacteria involved in bovine foot rot.

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Rifampicin: Brucellosis in Horses

Bactericidal antibiotic that inhibits RNA synthesis. It is effective against Staphylococcus, Mycobacterium, Legionella, Listeria, Haemophilus, and Brucella in horses.

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Rifampicin and its Targets

A group of antibiotics that target RNA synthesis. They are effective against a wide range of bacteria, including Staphylococcus, Mycobacterium, Legionella, Listeria, Haemophilus, and Brucella in horses.

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Fluoroquinolones

A group of antibiotics that target bacterial DNA gyrase, an enzyme essential for bacterial DNA replication. They are effective against a wide range of bacteria, including Enterobacter, Salmonella, Brucella, Chlamydia, Staphylococcus, Mycoplasma, and Mycobacteria. Fourth generation fluoroquinolones like Moxifloxacin and Gemifloxacin are newer and often more potent variations.

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Fluoroquinolones: Targets

A group of antibiotics that are specifically effective against a wide range of Gram-negative bacteria, including Enterobacter, Salmonella, Brucella, Chlamydia, Staphylococcus, Mycoplasma, and Mycobacteria.

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Carbapenems

A group of antibiotics that target a broad range of bacteria, including gram-positive and gram-negative organisms. They are effective against various bacterial infections, such as pneumonia, urinary tract infections, and skin infections.

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When are Carbapenems used?

Carbapenems are typically reserved for treating infections caused by multidrug-resistant bacteria, which have become resistant to other antibiotics.

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What is the common structure of carbapenems?

Carbapenems have a suffix 'penem', such as Imipenem and Doripenem. They are often used to treat severe infections caused by multidrug-resistant bacteria.

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How do beta-Lactamase Inhibitors work?

These antibiotics work by inhibiting the growth of bacteria by blocking the synthesis of their cell walls.

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What is the purpose of using Beta-Lactamase Inhibitors?

Beta-Lactamase Inhibitors are often paired with beta-lactam antibiotics to boost their effectiveness. They enhance the action of beta-lactams by protecting them from being broken down by bacterial enzymes.

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What kind of infections do Beta-Lactamase Inhibitors treat?

Beta-Lactamase Inhibitors are often used to treat infections caused by bacteria that produce specific enzymes like beta-lactamase, which can break down penicillin-based antibiotics. Examples of bacteria include Methicillin-resistant Staphylococcus aureus (MRSA), Enterobacteriaceae (Klebsiella, Proteus, Salmonella, Shigella, E.coli), Haemophilus, Pseudomonas, and Mycobacterium.

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How do Beta-Lactamase Inhibitors differ in structure?

Beta-Lactamase Inhibitors have common suffix 'bactam', such as Clavulanic acid and Sulbactam. They are most commonly given in combination with a beta-Lactam antibiotic.

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What is Vancomycin?

Vancomycin is a powerful antibiotic that primarily targets Gram-positive bacteria.

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Melitensis

A type of brucellosis that is only found during the R colonial phase. It is a subset of Brucellosis.

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ABOTOGENIC Brucellosis in GESTATION

A brucellosis infection that appears during the second part of gestation, if caused by Brucella abortus.

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Staining for Brucellosis Diagnosis

A diagnostic method for Brucellosis that involves staining the bacteria with a special dye. It helps to identify the presence of Brucella in infected samples.

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Partial Acid-Fast Staining

A specific staining technique used for detecting Brucella bacteria in samples. It relies on the bacteria's partial acid-fast property.

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Culture for Brucellosis Diagnosis

A culture method for growing and identifying Brucella bacteria in samples. It utilizes specialized media like Brucella agar, Modified Farrell’s Medium, and Serum Dextrose Agar at specific temperatures.

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Direct Identification of Brucella Species

A method for directly identifying Brucella species based on specific proteins. It uses techniques like immunofluorescence and specific protein analysis.

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Serology for Brucellosis Diagnosis

A test used to detect the presence of antibodies against Brucella in the blood serum. It is an essential tool for diagnosing Brucellosis.

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STAT (Serum Tube Agglutination) Test for Brucellosis

A serological test that measures antibody levels against Brucella in serum. A positive result usually indicates active infection.

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Staphylococcus aureus Mastitis

A type of mastitis caused by Staphylococcus aureus. This type of mastitis often progresses into a chronic condition characterized by inflammation, fibrosis, and sclerosis of the udder.

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Somatic Cell Count (SCC)

The number of somatic cells per milliliter of milk. This is used as an indicator of udder health and can be used to detect mastitis.

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Demarcation Line

A clinical sign of mastitis characterized by a visible line separating healthy tissue from the infected area. It indicates the progression of the inflammation in the udder.

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Streptococcus agalactiae Mastitis

A type of mastitis caused by Streptococcus agalactiae, commonly found in older cows and during early lactation. Known for its highly contagious nature.

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Duct Epithelium Damage

Inflammation and damage to the duct epithelium, often leading to necrosis, erosion, and ulceration.

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Neutrophil Infiltration

Increased presence of neutrophils in the subepithelial tissue, indicating a strong immune response to the infection.

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Proteinaceous Materia in Milk

Milk with abnormal components, including protein and other materials, due to infection and inflammation in the mammary gland.

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Intravenous Isotonic Fluid Therapy

Fluid therapy, often administered intravenously, to support the cow's body during a severe mastitis infection.

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Intravenous Antibiotics

A type of antibiotics used to treat mastitis, often given intravenously at the start of treatment.

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Mastectomy

Removing part or all of the infected udder to control the spread of the infection. This is considered a last resort when other treatments fail.

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Brucellosis Entry Routes

The entry of Brucella abortus into the body through the skin, digestive tract, or mucosal membranes.

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Brucellosis Contagiosity

The ability of Brucella abortus to spread easily between animals and potentially to humans.

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Intermittent Bacteremia

The intermittent presence of Brucella abortus in the bloodstream, often during the acute phase of infection.

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Brucellosis Latency

The ability of Brucella abortus to survive and remain dormant within the body, especially in macrophages, liver, spleen, and udder lymph nodes.

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Erythritol Chemotaxis

The attraction of Brucella abortus to erythritol, a sugar produced by fetal tissues, which contributes to the bacteria's invasion of the pregnant uterus.

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Brucellosis Shedding in Milk

The shedding of Brucella abortus in milk, primarily by infected pregnant animals.

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Endometritis

Inflammation of the uterus, often leading to abortion, in female animals.

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Brucellosis Abortions

The occurrence of abortions in pregnant animals, typically between the sixth and ninth month, as a result of Brucella abortus infection.

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Orchitis

Inflammation of the testicles in male animals, leading to a decrease in sperm production and infertility.

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Epididymitis

Inflammation of the epididymis, a structure located next to the testicle, caused by Brucella abortus infection.

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Brucellosis Joint Disorders

Inflammation of the joints, tendons, and bursae, leading to pain and lameness in animals infected with Brucella abortus.

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Brucellosis Cardiac Lesions

The presence of vegetative endocarditis, a condition that affects the heart valves, in animals infected with Brucella abortus.

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Brucellosis Granulomas

The presence of granulomas, small nodules of inflammatory tissue, in various organs like the reproductive tract, udder, lymph nodes, and joints, as a result of Brucella abortus infection.

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Brucellosis Diagnosis

The methods used to diagnose Brucellosis, including clinical observation, necropsy (post-mortem examination), and laboratory tests.

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Brucellosis Prevention

The methods used to prevent Brucellosis, including general hygiene measures, serological testing of animals, and vaccination.

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Study Notes

Infectious Disease MV5 S1

  • The course content covers a range of infectious diseases.
  • The image used is a meme, referring to a significant event as "the great shit storm of our time."
  • The following information is based primarily on content from pages 2-14.
  • Significant topics include antibiotics and various disease complexes, listing specific bacteria and their implications on numerous animals (Cattle, Pigs, Horses, etc).

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Test your knowledge on antibiotics and their mechanisms with this quiz. Focus on key medications like Metronidazole and Rifampicin while exploring their specific uses and effects. Perfect for pharmacology students or anyone interested in antibiotic treatment.

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