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Questions and Answers
Which of the following statements regarding reconstituted medications is correct?
Which of the following statements regarding reconstituted medications is correct?
A 3-year-old child is diagnosed with acute otitis media. What is the recommended oral dosage of amoxicillin for this condition, based on the content?
A 3-year-old child is diagnosed with acute otitis media. What is the recommended oral dosage of amoxicillin for this condition, based on the content?
Which of the following antibiotics is NOT effective against Pseudomonas aeruginosa?
Which of the following antibiotics is NOT effective against Pseudomonas aeruginosa?
Which of the following beta-lactam antibiotics is available in both intravenous (IV) and oral (PO) formulations?
Which of the following beta-lactam antibiotics is available in both intravenous (IV) and oral (PO) formulations?
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Which of the following antibiotics is a fifth-generation cephalosporin with activity against MRSA?
Which of the following antibiotics is a fifth-generation cephalosporin with activity against MRSA?
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Which of the following is a known adverse effect associated with the long-term use of omeprazole?
Which of the following is a known adverse effect associated with the long-term use of omeprazole?
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Omeprazole inhibits which specific cytochrome P450 enzyme?
Omeprazole inhibits which specific cytochrome P450 enzyme?
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Which of the following is NOT a typical anticholinergic effect?
Which of the following is NOT a typical anticholinergic effect?
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Which of the following medication is classified as a first-generation antihistamine?
Which of the following medication is classified as a first-generation antihistamine?
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Which of the following is a known inducer of CYP450 enzymes?
Which of the following is a known inducer of CYP450 enzymes?
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What is the primary purpose of a Phase I clinical trial?
What is the primary purpose of a Phase I clinical trial?
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What does the term 'bioavailability' refer to in pharmacology?
What does the term 'bioavailability' refer to in pharmacology?
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According to the list of ISMP guidelines, which of the following is NOT a recommended practice?
According to the list of ISMP guidelines, which of the following is NOT a recommended practice?
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Which of the following antibiotics is correctly paired with the bacterial species it is indicated to treat?
Which of the following antibiotics is correctly paired with the bacterial species it is indicated to treat?
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Which of the following drug classes inhibits cell wall synthesis?
Which of the following drug classes inhibits cell wall synthesis?
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A bacterium has developed resistance to sulfonamides by acquiring the ability to scavenge folic acid from its environment. This is an example of which resistance mechanism?
A bacterium has developed resistance to sulfonamides by acquiring the ability to scavenge folic acid from its environment. This is an example of which resistance mechanism?
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What is the maximum daily dose of acetaminophen for an adult?
What is the maximum daily dose of acetaminophen for an adult?
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A patient in their third trimester of pregnancy is experiencing pain. Which of the following analgesics is contraindicated due to the risk of premature closure of the ductus arteriosus?
A patient in their third trimester of pregnancy is experiencing pain. Which of the following analgesics is contraindicated due to the risk of premature closure of the ductus arteriosus?
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A patient has a prescription with the sig code 'OD'. What does this abbreviation signify?
A patient has a prescription with the sig code 'OD'. What does this abbreviation signify?
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A lactating patient requires a nasal decongestant. Which of the following is most likely to reduce milk production?
A lactating patient requires a nasal decongestant. Which of the following is most likely to reduce milk production?
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Which antibiotic inhibits protein synthesis?
Which antibiotic inhibits protein synthesis?
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A patient is prescribed ibuprofen. What is the maximum daily dose approved for children?
A patient is prescribed ibuprofen. What is the maximum daily dose approved for children?
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What is the primary mechanism of action of antacids in treating gastrointestinal issues?
What is the primary mechanism of action of antacids in treating gastrointestinal issues?
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A bacterium becomes resistant to beta-lactam antibiotics due to the production of beta-lactamase. This is an example of which resistance mechanism?
A bacterium becomes resistant to beta-lactam antibiotics due to the production of beta-lactamase. This is an example of which resistance mechanism?
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A patient needs a topical treatment for acne. Which concentration of salicylic acid is most appropriate?
A patient needs a topical treatment for acne. Which concentration of salicylic acid is most appropriate?
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Which of the following H2 receptor antagonists is known for inhibiting CYP450 enzymes, potentially affecting the metabolism of other drugs?
Which of the following H2 receptor antagonists is known for inhibiting CYP450 enzymes, potentially affecting the metabolism of other drugs?
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A patient seeks an over-the-counter option for cold symptoms during the first trimester of pregnancy. Which of the following is considered the first line option?
A patient seeks an over-the-counter option for cold symptoms during the first trimester of pregnancy. Which of the following is considered the first line option?
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What is the approximate percentage of an infant's dose of a Advil that can transfer through breast milk during lactation?
What is the approximate percentage of an infant's dose of a Advil that can transfer through breast milk during lactation?
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Which class of drugs, when used during pregnancy, has a potential risk of causing cleft lip/palate?
Which class of drugs, when used during pregnancy, has a potential risk of causing cleft lip/palate?
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Flashcards
Antacids
Antacids
A class of drugs that neutralize stomach acid and provide rapid relief from heartburn and indigestion. They work by buffering the acidic contents of the stomach.
H2 Receptor Antagonists
H2 Receptor Antagonists
A class of drugs that block the production of stomach acid by competitively inhibiting the H2 receptors in the stomach lining. They are used to treat conditions like peptic ulcers, GERD, and heartburn.
Proton Pump Inhibitors - PPIs
Proton Pump Inhibitors - PPIs
A class of drugs that irreversibly block the proton pump, which is the enzyme responsible for pumping hydrogen ions (H+) into the stomach lumen, effectively reducing acid secretion. They can take longer to take effect than H2 blockers, but their effects last longer.
Salicylic Acid
Salicylic Acid
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NSAIDS (Non-steroidal Anti-inflammatories) in Pregnancy
NSAIDS (Non-steroidal Anti-inflammatories) in Pregnancy
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Aspirin in Pregnancy
Aspirin in Pregnancy
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Antihistamines in Lactation
Antihistamines in Lactation
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Pseudoephedrine in Lactation
Pseudoephedrine in Lactation
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Albumin
Albumin
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Bioavailability
Bioavailability
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Anticholinergic Drugs
Anticholinergic Drugs
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Phase 1 Drug Trial
Phase 1 Drug Trial
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Phase 2 Drug Trial
Phase 2 Drug Trial
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Phase 3 Drug Trial
Phase 3 Drug Trial
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Cytochrome P450 (CYP) Enzymes
Cytochrome P450 (CYP) Enzymes
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CYP Inducers
CYP Inducers
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Refrigerating Reconstituted Medications
Refrigerating Reconstituted Medications
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Treating Otitis Media
Treating Otitis Media
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Cefdinir and Stool Color
Cefdinir and Stool Color
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Aminoglycosides
Aminoglycosides
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Treating Pseudomonas aeruginosa
Treating Pseudomonas aeruginosa
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Beta-lactams
Beta-lactams
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Vancomycin
Vancomycin
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Macrolides, Clindamycin, Linezolid, Tetracyclines, Aminoglycosides
Macrolides, Clindamycin, Linezolid, Tetracyclines, Aminoglycosides
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Quinolones
Quinolones
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Sulfonamides and Trimethoprim
Sulfonamides and Trimethoprim
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Antibiotic Inactivation/Modification
Antibiotic Inactivation/Modification
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Alteration of Target/Binding Site
Alteration of Target/Binding Site
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Bypassing Metabolic Inhibitions
Bypassing Metabolic Inhibitions
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Study Notes
OTC Drug Information
- OTC drugs include information on indications, classifications, mechanisms of action (MOAs), adverse effects, and interactions with other medications.
Salicylic Acid for Acne/Warts
- Salicylic acid (0.5-2%) treats acne, having low UV protection
- Higher concentrations (17-40%) are used to remove warts.
Medications for Pregnant Patients (NSAIDS)
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated in the third trimester due to potential complications like premature closure of the ductus arteriosus, prolonged labor, increased postpartum bleeding, and delayed parturition.
- Aspirin should be avoided throughout pregnancy.
- Azole topical therapies are preferred for 7 days during pregnancy.
- Intranasal cromolyn is a first-line option for colds, allergies, and coughs during pregnancy.
- Oxymetazoline is a preferred nasal decongestant during pregnancy (phenylephrine is for the first trimester, while pseudoephedrine can cause abdominal wall defects).
- Diphenhydramine and Chlorpheniramine are preferred antihistamines (second-generation antihistamines can also be used).
- Intranasal corticosteroids may cause cleft lip/palate and low birth weight.
Medications for Lactating Patients
- Infant doses should be 0.6-0.9%.
- Acetaminophen doses should be 3.98%.
- Aspirin should be avoided during lactation.
- Pseudoephedrine may reduce milk production.
- Antihistamines are contraindicated during lactation.
- Dextromethorphan, guaifenesin, benzocaine, camphor (topical), and menthol carry a low risk and are suitable for use during breastfeeding.
Gastrointestinal (GI) Treatment Medications (Antacids)
- Antacids have an onset of 5 minutes.
- Their mechanism of action involves buffering agents.
- Adverse effects are not a major concern, unless related to renal issues.
- Drug interactions involve chelation with divalent cations.
- Histamine type 2 receptor antagonists (e.g., cimetidine, famotidine) have an onset of 30-45 minutes.
- Their mechanism of action is blocking hydrochloric acid (HCl) production.
- Adverse effects include antiadrenergic properties.
Drug Interactions and CYP Enzymes
- Cimetidine inhibits CYP450 enzymes (1A2 and 2C19).
- Proton pump inhibitors (PPIs), like omeprazole, esomeprazole, and lansoprazole, have an onset of 60 minutes to days, blocking gastric secretion.
- PPIs are associated with increased risks of Clostridium difficile (C. diff), bacterial peritonitis, and osteoporosis with long-term use.
- Omeprazole inhibits CYP2C19.
- Various vitamins (C, B3, B9, B12) are mentioned but not extensively discussed.
- Understanding drug interactions and adverse effects, especially concerning anticholinergic drugs (dry mouth, blurred vision, urinary retention, constipation), is crucial. The first and second generation antihistamines are differentiated (e.g. diphenhydramine,loratadine).
Drug Trials Phases
- Phase 1 focuses on safety, involving 20-80 healthy volunteers (6-12 months).
- Phase 2 evaluates safety and efficacy (dose response), involving 100-300 subjects (1-2 years).
- Phase 3 determines safety and efficacy at specific doses, with involvement of a wide range of participants (hundreds to thousands).
Bioavailability and Albumin
- Bioavailability measures the percentage of a drug reaching systemic circulation.
- Albumin is a measure of protein.
- Important considerations for drug administration, and dosages need further elaboration.
Pediatric Pearls/Medication Expiry
- Reconstituted medications typically expire within 10-14 days and may require refrigeration.
- Specific drug combinations such as Clindamycin require flavoring and may cause stool discoloration.
- Treatment for acute uncomplicated otitis media (AOM): amoxicillin 90mg/kg/day orally, divided doses for 10 days, is noted for its effectiveness.
Antibiotics and Bacteria
- Various antibiotics and bacterial infections are listed across multiple pages, with information on routes of administration (e.g., intravenous (IV), oral (PO)).
- The study material highlights the importance of knowing the types of bacteria and appropriate antibiotics based on laboratory data for proper treatment protocols.
Antibiotic MOA and Adverse Reactions
- Information on the mechanisms of action (MOAs) of different antibiotics for various bacterial infections is given. The antibiotic treatment options are categorized by the type of bacterial infection being treated (e.g., CA-MRSA)
- Adverse reactions related to antibiotics require further exploration (reference to written notes).
Max Doses and Resistance Mechanisms
- Maximum dosages for acetaminophen, ibuprofen, and naproxen are specified.
- Specific resistance mechanisms in bacteria are outlined, including antibiotic inactivation, alteration of target sites, bypassing metabolic inhibition, and preventing accumulation of the antibiotic.
Significant Codes and Abbreviations
- Codes like "EAR" and "EYE" are mentioned, but without context, their meaning remains unclear.
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Description
Test your knowledge on reconstituted medications, antibiotics, and their appropriate dosages. This quiz covers various aspects of pharmacology, including drug classifications, adverse effects, and clinical trial phases. Perfect for students and professionals in the healthcare field!