30 Questions
What is the main adverse effect associated with bleomycin?
Pulmonary toxicity
Which phase of the cell cycle do cells accumulate in due to bleomycin treatment?
G2 phase
How does bleomycin cause DNA damage?
Attacks phosphodiester bonds of DNA
In which cancers is bleomycin primarily used for treatment?
Testicular cancers and Hodgkin lymphoma
Which enzyme is responsible for inactivating bleomycin and is high in tissues like liver and spleen?
Hydrolase
How does dexrazoxane protect against the cardiotoxicity of doxorubicin?
Chelates iron
What is the primary mechanism of action of antitumor antibiotics like anthracyclines?
Production of free radicals
Which of the following antitumor antibiotics is an exception to being cell cycle nonspecific?
Bleomycin
What is the therapeutic use of doxorubicin primarily in combination with other agents?
Sarcomas
Which antitumor antibiotic is the hydroxylated analog of daunorubicin?
Doxorubicin
Apart from intercalation, what other mechanism contributes to the cytotoxic effect of antitumor antibiotics?
Production of free radicals
Which agent is classified as an anthracycline antibiotic and is the 4-demethoxy analog of daunorubicin?
Idarubicin
How does temozolomide differ from dacarbazine in terms of metabolic transformation?
Temozolomide undergoes chemical transformation at normal physiological pH
In which type of cancers is dacarbazine mainly used?
Melanoma and Hodgkin lymphoma
What is the active metabolite responsible for the methylation of DNA with temozolomide?
MTIC
Which enzyme does temozolomide inhibit that is involved in DNA repair?
O-6guanine-DNA alkyltransferase
How is temozolomide administered for treatment?
Intravenously or orally
Which alkylating agent was originally developed as a vesicant during World War I?
Mechlorethamine
Which type of cancer is vinblastine commonly used to treat?
Metastatic testicular carcinoma
What is the mechanism of action of vinca alkaloids like vinblastine and vincristine?
Blocking mitosis by preventing tubulin polymerization
In which type of lung cancer is vinorelbine beneficial as a treatment option?
Advanced non–small cell lung cancer
Which of the following neoplasms is vincristine commonly used to treat?
Acute lymphoblastic leukemia in children
What distinguishes vinorelbine (VRB) from vincristine and vinblastine?
Less neurotoxicity
How do vinca alkaloids like vincristine and vinblastine affect microtubule formation?
Block tubulin polymerization
What is a common side effect associated with busulfan?
Pulmonary fibrosis
Why is the dose of melphalan carefully adjusted in patients?
By monitoring platelet and white blood cell counts
Which type of leukemia is chlorambucil commonly used to treat?
Chronic lymphocytic leukemia
What is the primary target disrupted by microtubule inhibitors in anticancer drugs?
Mitotic spindle
What is the main function of the mitotic spindle in eukaryotic cells?
Equal partitioning of DNA into daughter cells
Which feature makes bifunctional alkylating agents unique among anticancer drugs?
Variation in intestinal absorption and metabolism
This quiz covers the pharmacology of anti-cancer drugs, focusing on anthracyclines, bleomycin, alkylating agents, nitrosoureas, microtubule inhibitors like vincristine and paclitaxel, and more. Learn about their mechanisms of action and clinical applications.
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