Introduction to Anti-cancer Drugs Quiz
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Questions and Answers

Which of the following is NOT one of the objectives of the lecture?

  • Explaining the general concepts of anticancer agents
  • Discussing the example of gene mutations related to cancer (correct)
  • Listing and describing the short- & long-term toxicities of anticancer agents
  • Describing the role of cancer stem cells in cancer relapse & metastasis

    • What is the example given for a gene mutation that can cause chronic myelogenous leukemia (CML)?

  • BRCA1 gene mutation
  • ABL gene mutation (correct)
  • EGFR gene mutation
  • BRAF gene mutation

    • What is the relevance of understanding cell cycle dysregulations in cancer to tailoring therapies?

  • It enables tailoring the greatest therapies to individual cancer (correct)
  • It aids in identifying potential gene mutations
  • It helps in understanding the mechanism of cancer stem cells
  • It explains the dose-limiting toxicities of anticancer agents

    • What does an increase in the expression of oncogenes encode?

    <p>Proteins with potential to cause cancer</p> Signup and view all the answers

    What is the example given for a type of cancer caused by the Abl gene mutation?

    <p>Chronic myelogenous leukemia (CML)</p> Signup and view all the answers

    What is a major challenge associated with the treatment of cancer mentioned in the lecture objectives?

    <p>Overcoming resistance to anticancer drugs</p> Signup and view all the answers

    Which phase of the cell cycle involves DNA replication?

    <p>S phase</p> Signup and view all the answers

    What is the resting state in the cell cycle called?

    <p>G0 phase</p> Signup and view all the answers

    Which gene mutation is commonly associated with primary resistance in cancer cells?

    <p>p53 mutation</p> Signup and view all the answers

    What is one of the mechanisms involved in acquired resistance to anticancer drugs?

    <p>Decreased expression of P-glycoprotein efflux transporter</p> Signup and view all the answers

    Which type of toxicity is characterized by reversible alopecia?

    <p>Bone marrow suppression</p> Signup and view all the answers

    What is the main cause of chemotherapy-induced nausea and vomiting (CINV)?

    <p>Damage to the gastrointestinal tract epithelial cells</p> Signup and view all the answers

    Which drug is used to prevent hyperuricemia induced by anticancer agents?

    <p>Allopurinol</p> Signup and view all the answers

    What is the function of granulocyte-macrophage colony-stimulating factor (GM-CSF) in anticancer treatment?

    <p>Reversing bone marrow suppression adverse effects</p> Signup and view all the answers

    What is the main cause of blistering of skin from anticancer agents?

    <p>Extravasation of vesicants at the site of IV administration</p> Signup and view all the answers

    What can be used to treat megaloblastic anemia induced by methotrexate?

    <p>Leucovorin factor</p> Signup and view all the answers

    What is the main contributor factor to the development of anticancer drugs resistance?

    <p>Cancer stem cells</p> Signup and view all the answers

    What is the main characteristic of multiple drug resistance (MDR) in cancer patients?

    <p>Increased expression of MDR1 gene</p> Signup and view all the answers

    Which gene mutation is responsible for repairing DNA and when damaged by mutation, increases the risk for breast and ovarian cancer?

    <p>BRCA1/2</p> Signup and view all the answers

    Which drug inhibits angiogenesis in cancer cells?

    <p>Bevacizumab</p> Signup and view all the answers

    What is the main characteristic of cancer stem cells (CSCs)?

    <p>Self-renewal and generation of heterogeneous lineages of cancer cells</p> Signup and view all the answers

    What is the main problem with the selective toxicity of anticancer medications?

    <p>They have limited potential targets for selective toxicity</p> Signup and view all the answers

    What is the main reason for using a combination of anticancer drugs from different classes?

    <p>To enhance the efficacy and prevent resistance development</p> Signup and view all the answers

    Which type of anticancer agents attack cancer cells in a particular phase of the cell cycle?

    <p>Cell cycle specific (CCS) agents</p> Signup and view all the answers

    What is the primary treatment option for cancer that involves the removal of the tumor or cancerous tissue?

    <p>Surgery</p> Signup and view all the answers

    Which cell cycle phase do cell cycle nonspecific (CCNS) anticancer agents attack?

    <p>G0 or any phase of the cell cycle</p> Signup and view all the answers

    Which class of anticancer drugs are very effective against high growth fraction malignancies such as leukemia?

    <p>Cell cycle specific (CCS) agents</p> Signup and view all the answers

    What is the main cause of acquired resistance to apoptosis in cancer cells?

    <p>Inhibition of apoptotic machinery program</p> Signup and view all the answers

    What is the main characteristic that makes CSCs resistant to anti-cancers?

    <p>High degree of resistance to anti-cancers</p> Signup and view all the answers

    What is the primary reason for using a body surface area-based dose calculation for anticancer drugs?

    <p>To decrease the risk of adverse effects</p> Signup and view all the answers

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