30 Questions
Which of the following is NOT one of the objectives of the lecture?
Discussing the example of gene mutations related to cancer
What is the example given for a gene mutation that can cause chronic myelogenous leukemia (CML)?
ABL gene mutation
What is the relevance of understanding cell cycle dysregulations in cancer to tailoring therapies?
It enables tailoring the greatest therapies to individual cancer
What does an increase in the expression of oncogenes encode?
Proteins with potential to cause cancer
What is the example given for a type of cancer caused by the Abl gene mutation?
Chronic myelogenous leukemia (CML)
What is a major challenge associated with the treatment of cancer mentioned in the lecture objectives?
Overcoming resistance to anticancer drugs
Which phase of the cell cycle involves DNA replication?
S phase
What is the resting state in the cell cycle called?
G0 phase
Which gene mutation is commonly associated with primary resistance in cancer cells?
p53 mutation
What is one of the mechanisms involved in acquired resistance to anticancer drugs?
Decreased expression of P-glycoprotein efflux transporter
Which type of toxicity is characterized by reversible alopecia?
Bone marrow suppression
What is the main cause of chemotherapy-induced nausea and vomiting (CINV)?
Damage to the gastrointestinal tract epithelial cells
Which drug is used to prevent hyperuricemia induced by anticancer agents?
Allopurinol
What is the function of granulocyte-macrophage colony-stimulating factor (GM-CSF) in anticancer treatment?
Reversing bone marrow suppression adverse effects
What is the main cause of blistering of skin from anticancer agents?
Extravasation of vesicants at the site of IV administration
What can be used to treat megaloblastic anemia induced by methotrexate?
Leucovorin factor
What is the main contributor factor to the development of anticancer drugs resistance?
Cancer stem cells
What is the main characteristic of multiple drug resistance (MDR) in cancer patients?
Increased expression of MDR1 gene
Which gene mutation is responsible for repairing DNA and when damaged by mutation, increases the risk for breast and ovarian cancer?
BRCA1/2
Which drug inhibits angiogenesis in cancer cells?
Bevacizumab
What is the main characteristic of cancer stem cells (CSCs)?
Self-renewal and generation of heterogeneous lineages of cancer cells
What is the main problem with the selective toxicity of anticancer medications?
They have limited potential targets for selective toxicity
What is the main reason for using a combination of anticancer drugs from different classes?
To enhance the efficacy and prevent resistance development
Which type of anticancer agents attack cancer cells in a particular phase of the cell cycle?
Cell cycle specific (CCS) agents
What is the primary treatment option for cancer that involves the removal of the tumor or cancerous tissue?
Surgery
Which cell cycle phase do cell cycle nonspecific (CCNS) anticancer agents attack?
G0 or any phase of the cell cycle
Which class of anticancer drugs are very effective against high growth fraction malignancies such as leukemia?
Cell cycle specific (CCS) agents
What is the main cause of acquired resistance to apoptosis in cancer cells?
Inhibition of apoptotic machinery program
What is the main characteristic that makes CSCs resistant to anti-cancers?
High degree of resistance to anti-cancers
What is the primary reason for using a body surface area-based dose calculation for anticancer drugs?
To decrease the risk of adverse effects
Test your knowledge of anti-cancer drugs with this quiz covering hallmarks of cancer, cell cycle dysregulations, cancer stem cells, and more. Prepare for your pharmacology studies with this comprehensive quiz.
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