Pharmacological Treatment of Pain Quiz

What is the mechanism of action of acetaminophen?

Inhibits COX-1 in the CNS

Which opioid receptor subtype do codeine and morphine primarily act on?

Mu-receptor

What is a common side effect associated with opioids?

Miosis

How does lidocaine produce its pharmacological effect?

Blocking voltage-gated Na+ channels Signup and view all the answers

Which local anesthetic acts as an agonist at TRPV1 receptors?

Capsaicin Signup and view all the answers

Which antidepressant drug blocks the uptake of serotonin and norepinephrine?

Amitriptyline Signup and view all the answers

How does carbamazepine work as an anticonvulsant?

Preventing action potential by Na+ channel blockade Signup and view all the answers

'Capsaicin' is used for the management of which type of pain?

'Capsaicin' is used for managing neuropathic pain. Signup and view all the answers

'Gabapentin' has what effect on presynaptic N, L, P/Q-type voltage-gated Ca2+ channels?

'Gabapentin' inhibits these channels. Signup and view all the answers

'Ketamine' is primarily used for which therapeutic purpose?

'Ketamine' is primarily used for general anesthesia and neuropathic pain. Signup and view all the answers

What is the definition of pain according to the 2020 revised definition by the International Association for the Study of Pain (IASP)?

An unpleasant sensory and emotional experience associated with actual or potential tissue damage Signup and view all the answers

Which chemical mediator of pain is released after tissue trauma and contributes to augmented sensitivity to stimuli in the area surrounding an injury?

Prostaglandins Signup and view all the answers

What type of pain is associated with a maladaptive response to damage or disease of the somatosensory nervous system?

Neuropathic pain Signup and view all the answers

Which drug class is commonly used for treating neuropathic pain due to its action on the central and/or peripheral disorder of pain modulation?

Antidepressants Signup and view all the answers

Which term describes exaggerated sensitivity to stimuli in the area surrounding an injury?

Hyperalgesia Signup and view all the answers

Which drug is commonly used to treat nociceptive pain associated with inflammatory, ischemic, infectious, or mechanical injury?

Ibuprofen Signup and view all the answers

What kind of injury or disease typically leads to nociceptive pain?

Threats or results from bodily tissue damage Signup and view all the answers

What term best describes pain that occurs in the absence of active noxious stimulus?

Allodynia Signup and view all the answers

What is the primary difference between nociceptive and neuropathic pain?

Nociceptive pain is associated with inflammatory conditions, while neuropathic pain involves damage or disease of the somatosensory nervous system. Signup and view all the answers

What is the primary mechanism of action for non-steroidal anti-inflammatory drugs (NSAIDs)?

Inhibiting cyclooxygenase (COX) enzymes to decrease prostaglandin production Signup and view all the answers

What is the main difference between the mechanisms of nociceptive and neuropathic pain?

All of the above Signup and view all the answers

Which of the following is a characteristic of COX-1 enzymes?

Responsible for producing prostaglandins involved in mucosal protection and platelet aggregation Signup and view all the answers

Which of the following statements about aspirin is true?

It is used for the reduction of risk of myocardial infarction and transient ischemic attack Signup and view all the answers

Which of the following is a chronic pain disorder classified as neuropathic pain?

Trigeminal neuralgia Signup and view all the answers

What is the primary difference between the mechanisms of action of aspirin and ibuprofen?

Aspirin irreversibly inhibits COX enzymes, while ibuprofen competitively inhibits them Signup and view all the answers

What is the primary function of COX-2 enzymes?

Producing prostaglandins in response to inflammatory stimuli Signup and view all the answers