Pharmacological Treatment of Pain Quiz
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Questions and Answers

What is the mechanism of action of acetaminophen?

  • Inhibits COX-2 in the CNS
  • Enhances prostaglandins in the brain
  • Inhibits COX-1 in the periphery
  • Inhibits COX-1 in the CNS (correct)

    • Which opioid receptor subtype do codeine and morphine primarily act on?

  • Delta-receptor
  • Sigma-receptor
  • Mu-receptor (correct)
  • Kappa-receptor

    • What is a common side effect associated with opioids?

  • Mydriasis
  • Miosis (correct)
  • Hypertension
  • Hyperactivity

    • How does lidocaine produce its pharmacological effect?

    <p>Blocking voltage-gated Na+ channels</p> Signup and view all the answers

    Which local anesthetic acts as an agonist at TRPV1 receptors?

    <p>Capsaicin</p> Signup and view all the answers

    Which antidepressant drug blocks the uptake of serotonin and norepinephrine?

    <p>Amitriptyline</p> Signup and view all the answers

    How does carbamazepine work as an anticonvulsant?

    <p>Preventing action potential by Na+ channel blockade</p> Signup and view all the answers

    'Capsaicin' is used for the management of which type of pain?

    <p>'Capsaicin' is used for managing neuropathic pain.</p> Signup and view all the answers

    'Gabapentin' has what effect on presynaptic N, L, P/Q-type voltage-gated Ca2+ channels?

    <p>'Gabapentin' inhibits these channels.</p> Signup and view all the answers

    'Ketamine' is primarily used for which therapeutic purpose?

    <p>'Ketamine' is primarily used for general anesthesia and neuropathic pain.</p> Signup and view all the answers

    What is the definition of pain according to the 2020 revised definition by the International Association for the Study of Pain (IASP)?

    <p>An unpleasant sensory and emotional experience associated with actual or potential tissue damage</p> Signup and view all the answers

    Which chemical mediator of pain is released after tissue trauma and contributes to augmented sensitivity to stimuli in the area surrounding an injury?

    <p>Prostaglandins</p> Signup and view all the answers

    What type of pain is associated with a maladaptive response to damage or disease of the somatosensory nervous system?

    <p>Neuropathic pain</p> Signup and view all the answers

    Which drug class is commonly used for treating neuropathic pain due to its action on the central and/or peripheral disorder of pain modulation?

    <p>Antidepressants</p> Signup and view all the answers

    Which term describes exaggerated sensitivity to stimuli in the area surrounding an injury?

    <p>Hyperalgesia</p> Signup and view all the answers

    Which drug is commonly used to treat nociceptive pain associated with inflammatory, ischemic, infectious, or mechanical injury?

    <p>Ibuprofen</p> Signup and view all the answers

    What kind of injury or disease typically leads to nociceptive pain?

    <p>Threats or results from bodily tissue damage</p> Signup and view all the answers

    What term best describes pain that occurs in the absence of active noxious stimulus?

    <p>Allodynia</p> Signup and view all the answers

    What is the primary difference between nociceptive and neuropathic pain?

    <p>Nociceptive pain is associated with inflammatory conditions, while neuropathic pain involves damage or disease of the somatosensory nervous system.</p> Signup and view all the answers

    What is the primary mechanism of action for non-steroidal anti-inflammatory drugs (NSAIDs)?

    <p>Inhibiting cyclooxygenase (COX) enzymes to decrease prostaglandin production</p> Signup and view all the answers

    What is the main difference between the mechanisms of nociceptive and neuropathic pain?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a characteristic of COX-1 enzymes?

    <p>Responsible for producing prostaglandins involved in mucosal protection and platelet aggregation</p> Signup and view all the answers

    Which of the following statements about aspirin is true?

    <p>It is used for the reduction of risk of myocardial infarction and transient ischemic attack</p> Signup and view all the answers

    Which of the following is a chronic pain disorder classified as neuropathic pain?

    <p>Trigeminal neuralgia</p> Signup and view all the answers

    What is the primary difference between the mechanisms of action of aspirin and ibuprofen?

    <p>Aspirin irreversibly inhibits COX enzymes, while ibuprofen competitively inhibits them</p> Signup and view all the answers

    What is the primary function of COX-2 enzymes?

    <p>Producing prostaglandins in response to inflammatory stimuli</p> Signup and view all the answers

    Which of the following is a potential side effect associated with non-selective NSAIDs?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is an example of a mixed chronic pain disorder?

    <p>Fibromyalgia</p> Signup and view all the answers

    What is the primary function of COX-3 enzymes?

    <p>Serving as a target for acetaminophen</p> Signup and view all the answers

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