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Pharmacological Interactions and Hypertensive Crises

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Pharmacological Interactions and Hypertensive Crises

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Questions and Answers

What is the primary reason for administering multiple doses of activated charcoal in patients with glipizide overdose?

To accelerate the metabolism of glipizide in the liver

To reduce the risk of gastrointestinal bleeding

To enhance the absorption of glipizide in the gut

To counteract the effects of enterohepatic circulation (correct)

What is the mechanism by which multiple doses of activated charcoal can help in glipizide overdose?

By promoting the excretion of glipizide in the kidneys

By blocking the binding of glipizide to its receptors

By reducing the absorption of glipizide in the gut (correct)

By inhibiting the metabolism of glipizide in the liver

Why is glipizide more likely to cause prolonged hypoglycemic effects compared to other oral hypoglycemic agents?

Because it has a longer half-life

Because it is more lipophilic

Because it undergoes extensive first-pass metabolism

Because it has an enterohepatic circulation (correct)

What is the expected outcome of administering multiple doses of activated charcoal in patients with glipizide overdose?

Reduced risk of hypoglycemic episodes Signup and view all the answers

What is the primary benefit of using activated charcoal in the management of glipizide overdose?

Its ability to reduce the absorption of glipizide in the gut Signup and view all the answers

What should be avoided until the patient's mental status is fully restored?

Giving medication by mouth Signup and view all the answers

When is it safe to administer oral medications to a patient?

When the patient has fully regained mental status Signup and view all the answers

What is the primary consideration when deciding when to administer oral medications?

The patient's level of consciousness Signup and view all the answers

Why is it important to wait until a patient has fully regained mental status before administering oral medications?

To prevent aspiration or choking Signup and view all the answers

What is the most important factor in determining when to administer oral medications to a patient?