9 Questions
Which MAO-B inhibitor provides modest improvements in motor function as monotherapy in early PD?
Rasagiline
What is the essential moiety for conferring irreversible inhibition of MAO-B in rasagiline and selegiline?
Propargylamine
Which opioid analgesic is contraindicated with concomitant use of MAO-B inhibitors due to serotonin syndrome?
Meperidine
Which MAO-B inhibitor provides reversible inhibition of MAO-B?
Safinamide
Which MAO-B inhibitor can worsen preexisting dyskinesias or psychiatric symptoms, such as delusions?
Selegiline
Which adverse effect is associated with selegiline?
Hallucinations
Which MAO-B inhibitor can increase levodopa peak effects and worsen preexisting dyskinesias or psychiatric symptoms, such as delusions?
Selegiline
Which opioid analgesic is contraindicated with concomitant use of MAO-B inhibitors due to serotonin syndrome?
Meperidine
Which two MAO-B inhibitors contain a propargylamine moiety for conferring irreversible inhibition of MAO-B?
Rasagiline and Selegiline
Study Notes
MAO-B Inhibitors in Parkinson's Disease
- Rasagiline provides modest improvements in motor function as monotherapy in early Parkinson's disease (PD).
Mechanism of Action
- The essential moiety for conferring irreversible inhibition of MAO-B in rasagiline and selegiline is the propargylamine moiety.
Contraindications and Interactions
- Meperidine (an opioid analgesic) is contraindicated with concomitant use of MAO-B inhibitors due to serotonin syndrome.
Types of MAO-B Inhibitors
- Selegiline and rasagiline are MAO-B inhibitors that provide irreversible inhibition of MAO-B.
- Safinamide is a MAO-B inhibitor that provides reversible inhibition of MAO-B.
Adverse Effects
- Selegiline can cause insomnia and orthostatic hypotension.
- Rasagiline can worsen preexisting dyskinesias or psychiatric symptoms, such as delusions.
- Safinamide can increase levodopa peak effects and worsen preexisting dyskinesias or psychiatric symptoms, such as delusions.
Structural Characteristics
- Rasagiline and selegiline are the two MAO-B inhibitors that contain a propargylamine moiety for conferring irreversible inhibition of MAO-B.
Test your knowledge about the selective Monoamine Oxidase B (MAO-B) inhibitors rasagiline, safinamide, and selegiline used in the treatment of Parkinson's Disease. Learn about their unique properties and contraindications.
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