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Questions and Answers
Which MAO-B inhibitor provides modest improvements in motor function as monotherapy in early PD?
Which MAO-B inhibitor provides modest improvements in motor function as monotherapy in early PD?
- Rasagiline (correct)
- Selegiline
- Meperidine
- Safinamide
What is the essential moiety for conferring irreversible inhibition of MAO-B in rasagiline and selegiline?
What is the essential moiety for conferring irreversible inhibition of MAO-B in rasagiline and selegiline?
- Norepinephrine
- Propargylamine (correct)
- Dopamine
- Serotonin
Which opioid analgesic is contraindicated with concomitant use of MAO-B inhibitors due to serotonin syndrome?
Which opioid analgesic is contraindicated with concomitant use of MAO-B inhibitors due to serotonin syndrome?
- Methadone
- Morphine
- Meperidine (correct)
- Fentanyl
Which MAO-B inhibitor provides reversible inhibition of MAO-B?
Which MAO-B inhibitor provides reversible inhibition of MAO-B?
Which MAO-B inhibitor can worsen preexisting dyskinesias or psychiatric symptoms, such as delusions?
Which MAO-B inhibitor can worsen preexisting dyskinesias or psychiatric symptoms, such as delusions?
Which adverse effect is associated with selegiline?
Which adverse effect is associated with selegiline?
Which MAO-B inhibitor can increase levodopa peak effects and worsen preexisting dyskinesias or psychiatric symptoms, such as delusions?
Which MAO-B inhibitor can increase levodopa peak effects and worsen preexisting dyskinesias or psychiatric symptoms, such as delusions?
Which opioid analgesic is contraindicated with concomitant use of MAO-B inhibitors due to serotonin syndrome?
Which opioid analgesic is contraindicated with concomitant use of MAO-B inhibitors due to serotonin syndrome?
Which two MAO-B inhibitors contain a propargylamine moiety for conferring irreversible inhibition of MAO-B?
Which two MAO-B inhibitors contain a propargylamine moiety for conferring irreversible inhibition of MAO-B?
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Study Notes
MAO-B Inhibitors in Parkinson's Disease
- Rasagiline provides modest improvements in motor function as monotherapy in early Parkinson's disease (PD).
Mechanism of Action
- The essential moiety for conferring irreversible inhibition of MAO-B in rasagiline and selegiline is the propargylamine moiety.
Contraindications and Interactions
- Meperidine (an opioid analgesic) is contraindicated with concomitant use of MAO-B inhibitors due to serotonin syndrome.
Types of MAO-B Inhibitors
- Selegiline and rasagiline are MAO-B inhibitors that provide irreversible inhibition of MAO-B.
- Safinamide is a MAO-B inhibitor that provides reversible inhibition of MAO-B.
Adverse Effects
- Selegiline can cause insomnia and orthostatic hypotension.
- Rasagiline can worsen preexisting dyskinesias or psychiatric symptoms, such as delusions.
- Safinamide can increase levodopa peak effects and worsen preexisting dyskinesias or psychiatric symptoms, such as delusions.
Structural Characteristics
- Rasagiline and selegiline are the two MAO-B inhibitors that contain a propargylamine moiety for conferring irreversible inhibition of MAO-B.
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