Podcast
Questions and Answers
Which protein is the first element in the MAPK cascade and the first oncogenic protein discovered in human tumors?
Which protein is the first element in the MAPK cascade and the first oncogenic protein discovered in human tumors?
What is the common mutation found in K-Ras that leads to its activation?
What is the common mutation found in K-Ras that leads to its activation?
Which Ras isoform was identified in human neuroblastoma?
Which Ras isoform was identified in human neuroblastoma?
What effect does the SNP in K-Ras have on the protein?
What effect does the SNP in K-Ras have on the protein?
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Which type of tumors are highly associated with activating mutations in RAS?
Which type of tumors are highly associated with activating mutations in RAS?
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What was the initial approach to inhibiting Ras?
What was the initial approach to inhibiting Ras?
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Why were statins tested in relation to Ras inhibition?
Why were statins tested in relation to Ras inhibition?
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Why did GTP analogues fail to show expected efficacy as inhibitors of Ras?
Why did GTP analogues fail to show expected efficacy as inhibitors of Ras?
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What was the main reason for considering Ras an undruggable target for a long time?
What was the main reason for considering Ras an undruggable target for a long time?
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Why did inhibitors targeting enzymes involved in post-translational lipid modification fail?
Why did inhibitors targeting enzymes involved in post-translational lipid modification fail?
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