Podcast
Play an AI-generated podcast conversation about this lesson
Questions and Answers
Which protein is the first element in the MAPK cascade and the first oncogenic protein discovered in human tumors?
Which protein is the first element in the MAPK cascade and the first oncogenic protein discovered in human tumors?
- KRAS
- Ras (correct)
- HRAS
- Raf
What is the common mutation found in K-Ras that leads to its activation?
What is the common mutation found in K-Ras that leads to its activation?
- Deletion of a codon
- Insertion of an extra codon
- Silent mutation in the codon for alanine
- SNP in the codon for glycine in position 12 (correct)
Which Ras isoform was identified in human neuroblastoma?
Which Ras isoform was identified in human neuroblastoma?
- TRAS
- KRAS
- NRAS (correct)
- HRAS
What effect does the SNP in K-Ras have on the protein?
What effect does the SNP in K-Ras have on the protein?
Signup and view all the answers
Which type of tumors are highly associated with activating mutations in RAS?
Which type of tumors are highly associated with activating mutations in RAS?
Signup and view all the answers
What was the initial approach to inhibiting Ras?
What was the initial approach to inhibiting Ras?
Signup and view all the answers
Why were statins tested in relation to Ras inhibition?
Why were statins tested in relation to Ras inhibition?
Signup and view all the answers
Why did GTP analogues fail to show expected efficacy as inhibitors of Ras?
Why did GTP analogues fail to show expected efficacy as inhibitors of Ras?
Signup and view all the answers
What was the main reason for considering Ras an undruggable target for a long time?
What was the main reason for considering Ras an undruggable target for a long time?
Signup and view all the answers
Why did inhibitors targeting enzymes involved in post-translational lipid modification fail?
Why did inhibitors targeting enzymes involved in post-translational lipid modification fail?
Signup and view all the answers
