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Questions and Answers
What does the volume of distribution (Vd) represent in pharmacokinetics?
What does the volume of distribution (Vd) represent in pharmacokinetics?
- The theoretical volume of blood/plasma totally cleared of drug per unit time
- The volume of blood totally cleared of drug per unit time
- The time taken for drug concentration in blood to fall to half its original value
- The amount of drug in the body divided by the concentration in the blood (correct)
How can the half-life of a drug (t1/2) be defined?
How can the half-life of a drug (t1/2) be defined?
- The drug concentration in plasma when the drug is initially administered
- The time taken for concentration of drug in blood to fall to half its original value (correct)
- The amount of drug removed per unit time
- The theoretical volume of blood/plasma cleared of drug per unit time
What does drug clearance (CL) represent in pharmacokinetics?
What does drug clearance (CL) represent in pharmacokinetics?
- The amount of drug in the body divided by the concentration in the blood
- The volume of blood totally cleared of drug per unit time (correct)
- The percentage of drug in the body eliminated per unit time
- The time taken for drug concentration in blood to fall to half its original value
Which term is used to represent the fraction/percentage of the drug eliminated per unit time?
Which term is used to represent the fraction/percentage of the drug eliminated per unit time?
In pharmacokinetics, what is the relationship between drug amount, concentration, and clearance?
In pharmacokinetics, what is the relationship between drug amount, concentration, and clearance?
What does the volume of distribution (Vd) of a drug represent?
What does the volume of distribution (Vd) of a drug represent?
What is the half-life of a drug (t1/2)?
What is the half-life of a drug (t1/2)?
Which parameter is used to calculate the amount of drug required to achieve desired steady-state concentration levels?
Which parameter is used to calculate the amount of drug required to achieve desired steady-state concentration levels?
What is drug clearance (Cl)?
What is drug clearance (Cl)?
What does the elimination constant (kel) determine for a drug?
What does the elimination constant (kel) determine for a drug?
What type of model considers the whole body as a single well-stirred compartment?
What type of model considers the whole body as a single well-stirred compartment?
In which model would you find a fast phase and a slow phase of drug redistribution between central and peripheral compartments?
In which model would you find a fast phase and a slow phase of drug redistribution between central and peripheral compartments?
Which parameter is used to describe the apparent volume in which a drug appears to be distributed in the body?
Which parameter is used to describe the apparent volume in which a drug appears to be distributed in the body?
What kind of relationship between drug concentration and time is seen in the one-compartment model?
What kind of relationship between drug concentration and time is seen in the one-compartment model?
Which model often involves drugs that equilibrate at different rates with various tissues in the body?
Which model often involves drugs that equilibrate at different rates with various tissues in the body?
What is the effect of increasing the dose of a drug that follows zero-order kinetics?
What is the effect of increasing the dose of a drug that follows zero-order kinetics?
What is the unit of the elimination rate constant (kel)?
What is the unit of the elimination rate constant (kel)?
What is the half-life of a drug (t1/2) a measure of?
What is the half-life of a drug (t1/2) a measure of?
Which of the following drugs follows zero-order kinetics at high doses?
Which of the following drugs follows zero-order kinetics at high doses?
What does the volume of distribution (Vd) signify?
What does the volume of distribution (Vd) signify?
Which type of drug would have a volume of distribution (Vd) less than 5L?
Which type of drug would have a volume of distribution (Vd) less than 5L?
In multiple oral dosing, what signifies the steady-state plasma concentration (Css)?
In multiple oral dosing, what signifies the steady-state plasma concentration (Css)?
What is the primary purpose of a loading dose in drug treatment?
What is the primary purpose of a loading dose in drug treatment?
How does an increase in the elimination constant (kel) affect the drug concentration in the body over time?
How does an increase in the elimination constant (kel) affect the drug concentration in the body over time?
