10 Questions
What is the mechanism by which probenecid inhibits the excretion of penicillins?
Competition for the same carrier system in active tubular secretion
What is the effect of increasing molecular weight of a drug on its excretion?
Decreases excretion
What is the effect of increasing renal blood flow on drug excretion?
Increases excretion
Why does renal impairment reduce drug excretion rate?
Decreased glomerular filtration rate
What is the effect of alkalinization of urine on the excretion of acidic drugs?
Increases excretion
What is the effect of acidification of urine on the excretion of basic drugs?
Increases excretion
What is the process by which conjugated drugs are broken down in the intestine and then reabsorbed?
Enterohepatic circulation
Which of the following substances can cause alkalinization of urine?
NaHCO3
What is the process by which drugs are conjugated with glucuronic acid in the liver?
Glucuronidation
What is the result of de-conjugation of drugs in the intestine due to enzymes of normal bacterial flora?
Reabsorption of the free drug
This quiz covers the concepts of elimination kinetics in pharmacokinetics, including first-order and zero-order elimination kinetics, and the factors affecting the rate of drug elimination from the body.
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