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Pharmacokinetics Chapter 23: Elimination Kinetics

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Pharmacokinetics Chapter 23: Elimination Kinetics

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Questions and Answers

What is the mechanism by which probenecid inhibits the excretion of penicillins?

Competition for the same carrier system in active tubular secretion (correct)

Inhibition of cytochrome P450 enzymes

Induction of glucuronic acid conjugation

Inhibition of P-glycoprotein

What is the effect of increasing molecular weight of a drug on its excretion?

Has no effect on excretion

Decreases excretion (correct)

Increases excretion

Enhances enterohepatic circulation

What is the effect of increasing renal blood flow on drug excretion?

Increases excretion (correct)

Has no effect on excretion

Decreases excretion

Enhances enterohepatic circulation

Why does renal impairment reduce drug excretion rate?

Decreased glomerular filtration rate Signup and view all the answers

What is the effect of alkalinization of urine on the excretion of acidic drugs?

Increases excretion Signup and view all the answers

What is the effect of acidification of urine on the excretion of basic drugs?

Increases excretion Signup and view all the answers

What is the process by which conjugated drugs are broken down in the intestine and then reabsorbed?

Enterohepatic circulation Signup and view all the answers

Which of the following substances can cause alkalinization of urine?

NaHCO3 Signup and view all the answers

What is the process by which drugs are conjugated with glucuronic acid in the liver?

Glucuronidation Signup and view all the answers

What is the result of de-conjugation of drugs in the intestine due to enzymes of normal bacterial flora?

Reabsorption of the free drug Signup and view all the answers