Pharmacokinetics Chapter 23: Elimination Kinetics
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Questions and Answers

What is the mechanism by which probenecid inhibits the excretion of penicillins?

  • Competition for the same carrier system in active tubular secretion (correct)
  • Inhibition of cytochrome P450 enzymes
  • Induction of glucuronic acid conjugation
  • Inhibition of P-glycoprotein

What is the effect of increasing molecular weight of a drug on its excretion?

  • Has no effect on excretion
  • Decreases excretion (correct)
  • Increases excretion
  • Enhances enterohepatic circulation

What is the effect of increasing renal blood flow on drug excretion?

  • Increases excretion (correct)
  • Has no effect on excretion
  • Decreases excretion
  • Enhances enterohepatic circulation

Why does renal impairment reduce drug excretion rate?

<p>Decreased glomerular filtration rate (A)</p> Signup and view all the answers

What is the effect of alkalinization of urine on the excretion of acidic drugs?

<p>Increases excretion (B)</p> Signup and view all the answers

What is the effect of acidification of urine on the excretion of basic drugs?

<p>Increases excretion (C)</p> Signup and view all the answers

What is the process by which conjugated drugs are broken down in the intestine and then reabsorbed?

<p>Enterohepatic circulation (D)</p> Signup and view all the answers

Which of the following substances can cause alkalinization of urine?

<p>NaHCO3 (D)</p> Signup and view all the answers

What is the process by which drugs are conjugated with glucuronic acid in the liver?

<p>Glucuronidation (B)</p> Signup and view all the answers

What is the result of de-conjugation of drugs in the intestine due to enzymes of normal bacterial flora?

<p>Reabsorption of the free drug (D)</p> Signup and view all the answers

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