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Pharmacokinetics of Glucocorticoids: Absorption and Fate

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Pharmacokinetics of Glucocorticoids: Absorption and Fate

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Questions and Answers

What is the potential benefit of alternate-day administration of corticosteroids?

Reducing the risk of infection

Allowing the HPA axis to recover on days the hormone is not taken (correct)

Increasing the absorption of calcium in the intestines

Decreasing the production of sex hormones

What is the most common adverse effect of long-term glucocorticoid therapy?

Cushing-like syndrome

Osteoporosis (correct)

Hypokalemia

Hypertension

What is the consequence of sudden discontinuation of glucocorticosteroids in patients with suppression of the HPA axis?

Hypoglycemia

Acute adrenal insufficiency (correct)

Hypertension

Emotional disturbances

Which drug is used to treat patients with Cushing syndrome?

Ketoconazole Signup and view all the answers

What is the role of spironolactone in the treatment of hypertension?

Competing for the mineralocorticoid receptor Signup and view all the answers

Why is it necessary to taper the dose of glucocorticosteroids slowly during discontinuation?

To prevent acute adrenal insufficiency Signup and view all the answers

What is the percentage of glucocorticoids bound to plasma proteins?

Greater than 90% Signup and view all the answers

What is the primary organ responsible for metabolizing corticosteroids?

Liver Signup and view all the answers

Why is prednisone preferred in pregnancy?

It has minimal effects on the fetus Signup and view all the answers

What is the fate of corticosteroids after metabolism?

They are conjugated to glucuronic acid or sulfate and excreted by the kidney Signup and view all the answers

What happens to the HPA axis when large doses of corticosteroids are required for more than 2 weeks?

It is suppressed Signup and view all the answers

What is the primary consideration when determining the dosage of corticosteroids?

Type of preparation Signup and view all the answers