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Master the Pharmacokinetics of Glucocorticoids

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Master the Pharmacokinetics of Glucocorticoids

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Questions and Answers

Which of the following is not a glucocorticoid effect?

Suppression of ACTH release
Decreased glucose utilization (correct)
Decreased gluconeogenesis
Decreased glycogenesis and glycogen storage by the liver

Which organ is responsible for the metabolism of glucocorticoids?

Lungs
Liver (correct)
Liver, B) Stomach, C) Heart, D) Brain
Pancreas

Which of the following is a catabolic effect of protein metabolism?

Catabolic effect in liver, C) Catabolic effect in muscles, D) Catabolic effect in bone, A) Anabolic effect in muscles
Anabolic effect in lymphoid T (correct)
Anabolic effect in bone
Anabolic effect in liver

Which hormone is suppressed by negative feedback by glucocorticoids?

Adrenocorticotropic hormone (ACTH (C) Signup and view all the answers

Which protein do glucocorticoids mainly bind to in the plasma?

Corticosteroid binding globulin (CBG (D) Signup and view all the answers

What is the effect of electrolytes and water metabolism on potassium levels?

Increase K excretion → Hypokalemia (D) Signup and view all the answers

Which effect of glucocorticoids is not a glucocorticoid effect?

Salt retention (C) Signup and view all the answers

Which of the following is a symptom of fat metabolism?

Redistribution of fat & deposition in central parts (D) Signup and view all the answers

What is the role of glucocorticoids in salt retention?

They increase salt retention as a mineralocorticoid effect. (D) Signup and view all the answers

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Description

Test your knowledge of the pharmacokinetics of glucocorticoids with this quiz! Learn about the absorption, distribution, and metabolism of these drugs, including how prodrugs like prednisone and cortisone are activated in the liver. Brush up on your understanding of glucocorticoid binding to plasma globulin and albumin, and see how well you know the conjugation process with glucuronic and sulfuric acids. Perfect for pharmacy students or healthcare professionals!