9 Questions
Quelle est la formule pour calculer t1/2 dans une infusion proportionnelle?
0.693 Vd/Kél
Quel est l'exemple de médicament cité dans le texte pour illustrer la nécessité d'une concentration plasmatique stable?
Le patch de fentanyl
Quel est l'impact du volume de distribution sur la concentration à l'état d'équilibre?
Le volume de distribution n'affecte pas la concentration à l'état d'équilibre
Quel est l'impact du volume de distribution sur le temps nécessaire pour atteindre l'état d'équilibre?
Le volume de distribution a un impact sur le temps nécessaire pour atteindre l'état d'équilibre
Qu'est-ce que la biodisponibilité?
La fraction de la dose qui atteint la circulation systémique
Qu'est-ce que la bioéquivalence considère?
AUC, Cmax et Tmax.
Quand se produisent les cinétiques non linéaires?
Lorsque le métabolisme est saturé.
Les cinétiques non linéaires ont-elles un état d'équilibre?
Non, les cinétiques non linéaires n'ont pas d'état d'équilibre
À quoi sert la dose de charge?
À atteindre plus rapidement l'état d'équilibre
Study Notes
- The text discusses the need for drugs to have stable plasma concentrations.
- The drug should be active at low plasma concentrations.
- The example given is the fentanyl patch.
- The speed of passage depends on something that is not specified in the text.
- The formula for calculating t1/2 in proportional infusion is 0.693 Vd/Kél.
- In bolus injection, less than 1% of the Ci remains in the blood after 7 half-lives.
- In continuous administration, steady state is reached after 4 half-lives.
- At the start, more medication is injected than eliminated.
- At steady state, medication elimination and injection are equal.
- Changing the medication concentration affects administration.
- The steady state concentration is the administration rate divided by clearance.
- The volume of distribution does not affect the steady state concentration.
- The volume of distribution impacts the time to reach the steady state.
- Two-compartment models have a central and peripheral compartment.
- Biodisponibility is the fraction of the dose that reaches the systemic circulation.
- Bioequivalence considers AUC, Cmax, and Tmax.
- Non-linear kinetics are rare and occur when metabolism is saturated.
- Non-linear kinetics do not have a steady state.
- The dose of charge can be used to reach the steady state faster.
- The steady state concentration is proportional to the dose given.
Test your knowledge on pharmacokinetics with this quiz! From understanding the importance of stable plasma concentrations to the formula for calculating t1/2 in proportional infusion, this quiz covers key concepts in drug administration. You'll also learn about the impact of volume of distribution, two-compartment models, and non-linear kinetics on drug administration. Sharpen your skills and see how much you know about pharmacokinetics!
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