Mastering Pharmacokinetics

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Questions and Answers

Which equation represents the half-life of a drug in the Compartment Based Clearance Model?

  • t1/2 = Vd CL / 0.693
  • t1/2 = 0.693 x ke
  • t1/2 = 0.693 / ke (correct)
  • t1/2 = 0.693 x Vd CL

Which of the following units is commonly used for the clearance (CL) in the Compartment Based Clearance Model?

  • mg/L
  • Liters/hour (correct)
  • Liters
  • Reciprocal time

According to the table provided, how many half-lives does it take for a drug concentration to decrease by 75%?

  • 2
  • 3 (correct)
  • 4
  • 1

Which of the following statements is true about achieving steady state in drug concentration?

<p>It takes 4-5 half-lives to achieve steady state. (D)</p> Signup and view all the answers

What is the formula to calculate the rate of drug removal in the Metoprolol example?

<p>Rate of drug removal (mg/hr) = rate constant ke (hr-1) x plasma concentration (mg/L) x Vd (L) (D)</p> Signup and view all the answers

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