Podcast
Questions and Answers
In a one-compartment model, what is the assumption about the distribution equilibrium between the drug plasma and other body fluids?
In a one-compartment model, what is the assumption about the distribution equilibrium between the drug plasma and other body fluids?
- It takes a long time to attain equilibrium
- It is not attained at all
- It is attained instantaneously and maintained at all times (correct)
- It depends on the drug's pharmacokinetic properties
What is the main difference between the central compartment and the peripheral compartment in a two-compartment model?
What is the main difference between the central compartment and the peripheral compartment in a two-compartment model?
- The central compartment has a slower elimination rate
- The central compartment is larger in size than the peripheral compartment
- The peripheral compartment has a faster distribution rate
- The central compartment includes blood and highly perfused organs, while the peripheral compartment includes poorly perfused and slow equilibrating tissues (correct)
What is the primary advantage of using a two-compartment model over a one-compartment model?
What is the primary advantage of using a two-compartment model over a one-compartment model?
- It is only used for certain types of drugs
- It provides a more accurate representation of the body's pharmacokinetic processes (correct)
- It is less computationally intensive
- It is simpler to use
What is the significance of the rate of elimination in zero-order elimination?
What is the significance of the rate of elimination in zero-order elimination?
What is the primary characteristic of first-order elimination in a one-compartment model?
What is the primary characteristic of first-order elimination in a one-compartment model?
What is the purpose of compartmental modeling in pharmacokinetics?
What is the purpose of compartmental modeling in pharmacokinetics?
What is the effect of increasing the dose on the rate of absorption?
What is the effect of increasing the dose on the rate of absorption?
What is the indication of the rate of absorption?
What is the indication of the rate of absorption?
What is the indication of the extent of absorption?
What is the indication of the extent of absorption?
What is the term used to describe the rate and extent of absorption of two or more identical dosage forms?
What is the term used to describe the rate and extent of absorption of two or more identical dosage forms?
What is the term used to describe the presence of the same labeled chemical substances as an active ingredient in the same amount?
What is the term used to describe the presence of the same labeled chemical substances as an active ingredient in the same amount?
What occurs when statistical significant differences are observed in the bioavailability of two or more drug products?
What occurs when statistical significant differences are observed in the bioavailability of two or more drug products?
What is the primary factor that affects drug absorption?
What is the primary factor that affects drug absorption?
What is the term for the study of the movement of a drug into, through, and out of the body over time?
What is the term for the study of the movement of a drug into, through, and out of the body over time?
What is the term for the process by which the body breaks down and eliminates a drug?
What is the term for the process by which the body breaks down and eliminates a drug?
What is the relationship between the rate of elimination and drug concentration in first-order kinetics?
What is the relationship between the rate of elimination and drug concentration in first-order kinetics?
What is the shape of a C vs. t graph in zero-order kinetics?
What is the shape of a C vs. t graph in zero-order kinetics?
What is the equation for the plot of log [drug] vs. time in first-order kinetics?
What is the equation for the plot of log [drug] vs. time in first-order kinetics?
