18 Questions
In a one-compartment model, what is the assumption about the distribution equilibrium between the drug plasma and other body fluids?
It is attained instantaneously and maintained at all times
What is the main difference between the central compartment and the peripheral compartment in a two-compartment model?
The central compartment includes blood and highly perfused organs, while the peripheral compartment includes poorly perfused and slow equilibrating tissues
What is the primary advantage of using a two-compartment model over a one-compartment model?
It provides a more accurate representation of the body's pharmacokinetic processes
What is the significance of the rate of elimination in zero-order elimination?
It is independent of the concentration of the drug
What is the primary characteristic of first-order elimination in a one-compartment model?
The rate of elimination is proportional to the concentration of the drug
What is the purpose of compartmental modeling in pharmacokinetics?
To describe the distribution and elimination of a drug in the body
What is the effect of increasing the dose on the rate of absorption?
It increases the rate of absorption
What is the indication of the rate of absorption?
Peak time (tmax)
What is the indication of the extent of absorption?
Area under the plasma level time curve (AUC)
What is the term used to describe the rate and extent of absorption of two or more identical dosage forms?
Bioequivalence
What is the term used to describe the presence of the same labeled chemical substances as an active ingredient in the same amount?
Chemical equivalence
What occurs when statistical significant differences are observed in the bioavailability of two or more drug products?
Bio-inequivalence
What is the primary factor that affects drug absorption?
Route of administration
What is the term for the study of the movement of a drug into, through, and out of the body over time?
Pharmacokinetics
What is the term for the process by which the body breaks down and eliminates a drug?
Biotransformation
What is the relationship between the rate of elimination and drug concentration in first-order kinetics?
The rate of elimination is directly proportional to drug concentration
What is the shape of a C vs. t graph in zero-order kinetics?
Linear
What is the equation for the plot of log [drug] vs. time in first-order kinetics?
ln C = ln Co - kt
Test your understanding of pharmacokinetics, including zero-order and first-order elimination, and compartment models. Learn how drugs are absorbed, distributed, and eliminated from the body.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
