Pharmacokinetics and Drug Elimination
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Questions and Answers

In a one-compartment model, what is the assumption about the distribution equilibrium between the drug plasma and other body fluids?

  • It takes a long time to attain equilibrium
  • It is not attained at all
  • It is attained instantaneously and maintained at all times (correct)
  • It depends on the drug's pharmacokinetic properties

    • What is the main difference between the central compartment and the peripheral compartment in a two-compartment model?

  • The central compartment has a slower elimination rate
  • The central compartment is larger in size than the peripheral compartment
  • The peripheral compartment has a faster distribution rate
  • The central compartment includes blood and highly perfused organs, while the peripheral compartment includes poorly perfused and slow equilibrating tissues (correct)

    • What is the primary advantage of using a two-compartment model over a one-compartment model?

  • It is only used for certain types of drugs
  • It provides a more accurate representation of the body's pharmacokinetic processes (correct)
  • It is less computationally intensive
  • It is simpler to use

    • What is the significance of the rate of elimination in zero-order elimination?

    <p>It is independent of the concentration of the drug</p> Signup and view all the answers

    What is the primary characteristic of first-order elimination in a one-compartment model?

    <p>The rate of elimination is proportional to the concentration of the drug</p> Signup and view all the answers

    What is the purpose of compartmental modeling in pharmacokinetics?

    <p>To describe the distribution and elimination of a drug in the body</p> Signup and view all the answers

    What is the effect of increasing the dose on the rate of absorption?

    <p>It increases the rate of absorption</p> Signup and view all the answers

    What is the indication of the rate of absorption?

    <p>Peak time (tmax)</p> Signup and view all the answers

    What is the indication of the extent of absorption?

    <p>Area under the plasma level time curve (AUC)</p> Signup and view all the answers

    What is the term used to describe the rate and extent of absorption of two or more identical dosage forms?

    <p>Bioequivalence</p> Signup and view all the answers

    What is the term used to describe the presence of the same labeled chemical substances as an active ingredient in the same amount?

    <p>Chemical equivalence</p> Signup and view all the answers

    What occurs when statistical significant differences are observed in the bioavailability of two or more drug products?

    <p>Bio-inequivalence</p> Signup and view all the answers

    What is the primary factor that affects drug absorption?

    <p>Route of administration</p> Signup and view all the answers

    What is the term for the study of the movement of a drug into, through, and out of the body over time?

    <p>Pharmacokinetics</p> Signup and view all the answers

    What is the term for the process by which the body breaks down and eliminates a drug?

    <p>Biotransformation</p> Signup and view all the answers

    What is the relationship between the rate of elimination and drug concentration in first-order kinetics?

    <p>The rate of elimination is directly proportional to drug concentration</p> Signup and view all the answers

    What is the shape of a C vs. t graph in zero-order kinetics?

    <p>Linear</p> Signup and view all the answers

    What is the equation for the plot of log [drug] vs. time in first-order kinetics?

    <p>ln C = ln Co - kt</p> Signup and view all the answers

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