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Questions and Answers
Which equation describes the line in the semilog plot of a drug given as i.v. bolus with nonlinear elimination and that fits one-compartment kinetics?
Which equation describes the line in the semilog plot of a drug given as i.v. bolus with nonlinear elimination and that fits one-compartment kinetics?
- $y = -V_{max}/2.303K_m + C_0$
- $y = V_{max}/2.303K_m + C_0$
- $y = V_{max}/2.303K_m$
- $y = -V_{max}/2.303K_m$ (correct)
What parameters can be assessed from the plasma concentration-time data collected after i.v. bolus administration of a drug with nonlinear elimination characteristics?
What parameters can be assessed from the plasma concentration-time data collected after i.v. bolus administration of a drug with nonlinear elimination characteristics?
- Km and C0
- Vmax and C0
- Km and Vmax (correct)
- Km, Vmax, and C0
What does a semilog plot of C versus t yield for a drug with nonlinear elimination and that fits one-compartment kinetics?
What does a semilog plot of C versus t yield for a drug with nonlinear elimination and that fits one-compartment kinetics?
- A curve with a constant slope
- A straight line
- A curve with an exponential decay
- A curve with a terminal linear portion (correct)
What is the slope of the terminal linear portion in the semilog plot of C versus t for a drug with nonlinear elimination and that fits one-compartment kinetics?
What is the slope of the terminal linear portion in the semilog plot of C versus t for a drug with nonlinear elimination and that fits one-compartment kinetics?
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What does the Y-intercept of the terminal linear portion in the semilog plot of C versus t represent?
What does the Y-intercept of the terminal linear portion in the semilog plot of C versus t represent?
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