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Capacity-Limited Processes in Pharmacokinetics

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Capacity-Limited Processes in Pharmacokinetics

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Questions and Answers

Which equation describes the line in the semilog plot of a drug given as i.v. bolus with nonlinear elimination and that fits one-compartment kinetics?

$y = -V_{max}/2.303K_m + C_0$

$y = V_{max}/2.303K_m + C_0$

$y = V_{max}/2.303K_m$

$y = -V_{max}/2.303K_m$ (correct)

What parameters can be assessed from the plasma concentration-time data collected after i.v. bolus administration of a drug with nonlinear elimination characteristics?

Km and C0

Vmax and C0

Km and Vmax (correct)

Km, Vmax, and C0

What does a semilog plot of C versus t yield for a drug with nonlinear elimination and that fits one-compartment kinetics?

A curve with a constant slope

A straight line

A curve with an exponential decay

A curve with a terminal linear portion (correct)

What is the slope of the terminal linear portion in the semilog plot of C versus t for a drug with nonlinear elimination and that fits one-compartment kinetics?

<p>$-V_{max}/2.303K_m$</p> Signup and view all the answers

What does the Y-intercept of the terminal linear portion in the semilog plot of C versus t represent?

<p>Log BarC0</p> Signup and view all the answers

Capacity-Limited Processes in Pharmacokinetics

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Questions and Answers

Which equation describes the line in the semilog plot of a drug given as i.v. bolus with nonlinear elimination and that fits one-compartment kinetics?

What parameters can be assessed from the plasma concentration-time data collected after i.v. bolus administration of a drug with nonlinear elimination characteristics?

What does a semilog plot of C versus t yield for a drug with nonlinear elimination and that fits one-compartment kinetics?

What is the slope of the terminal linear portion in the semilog plot of C versus t for a drug with nonlinear elimination and that fits one-compartment kinetics?

What does the Y-intercept of the terminal linear portion in the semilog plot of C versus t represent?

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