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Capacity-Limited Processes in Pharmacokinetics
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Capacity-Limited Processes in Pharmacokinetics

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Questions and Answers

Which equation describes the line in the semilog plot of a drug given as i.v. bolus with nonlinear elimination and that fits one-compartment kinetics?

  • $y = -V_{max}/2.303K_m + C_0$
  • $y = V_{max}/2.303K_m + C_0$
  • $y = V_{max}/2.303K_m$
  • $y = -V_{max}/2.303K_m$ (correct)

    • What parameters can be assessed from the plasma concentration-time data collected after i.v. bolus administration of a drug with nonlinear elimination characteristics?

  • Km and C0
  • Vmax and C0
  • Km and Vmax (correct)
  • Km, Vmax, and C0

    • What does a semilog plot of C versus t yield for a drug with nonlinear elimination and that fits one-compartment kinetics?

  • A curve with a constant slope
  • A straight line
  • A curve with an exponential decay
  • A curve with a terminal linear portion (correct)

    • What is the slope of the terminal linear portion in the semilog plot of C versus t for a drug with nonlinear elimination and that fits one-compartment kinetics?

    <p>$-V_{max}/2.303K_m$</p> Signup and view all the answers

    What does the Y-intercept of the terminal linear portion in the semilog plot of C versus t represent?

    <p>Log BarC0</p> Signup and view all the answers

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