19 protein synthesis inhibitor
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Questions and Answers

What is the primary route of excretion for erythromycin?

  • Feces
  • Urine
  • Bile (correct)
  • Sweat
  • Which of the following is a key pharmacokinetic advantage of clarithromycin over erythromycin?

  • Lower incidence of gastrointestinal side effects (correct)
  • Better acid stability
  • Longer half-life
  • Higher CSF penetration
  • Which of the following pathogens is azithromycin particularly effective against?

  • Anaerobic bacteria
  • Chlamydia species (correct)
  • Gram-positive bacteria
  • Gram-negative bacteria
  • What is the primary mechanism of action for macrolide antibiotics like erythromycin?

    <p>Inhibition of protein synthesis</p> Signup and view all the answers

    Which of the following is a common adverse effect associated with macrolide antibiotics?

    <p>Gastrointestinal intolerance</p> Signup and view all the answers

    Which of the following is a key therapeutic use of erythromycin?

    <p>Treatment of corynebacterial infections</p> Signup and view all the answers

    Which of the following is NOT a common adverse effect associated with macrolide antibiotics?

    <p>Hepatotoxicity</p> Signup and view all the answers

    Which macrolide antibiotic has the broadest spectrum of activity against Gram-positive and Gram-negative organisms?

    <p>Azithromycin</p> Signup and view all the answers

    What is the primary mechanism of action for macrolide antibiotics?

    <p>Binding to the 50S ribosomal subunit and inhibiting protein synthesis</p> Signup and view all the answers

    Which of the following is NOT a common clinical use for macrolide antibiotics?

    <p>Treatment of malaria</p> Signup and view all the answers

    What is the primary reason for the development of resistance to erythromycin, a macrolide antibiotic?

    <p>Modification of the ribosomal binding site</p> Signup and view all the answers

    Which adverse effect is associated with the use of macrolide antibiotics in newborn infants?

    <p>Gray baby syndrome</p> Signup and view all the answers

    Which of the following best describes the pharmacokinetics of macrolides?

    <p>Rapidly absorbed from the GI, widely distributed, and released slowly from tissues</p> Signup and view all the answers

    What is a common side effect associated with macrolides?

    <p>Cholestatic hepatitis</p> Signup and view all the answers

    Which macrolide is specifically active against penicillin- and erythromycin-resistant Streptococcus pneumoniae?

    <p>Telithromycin</p> Signup and view all the answers

    What is the mechanism of action of clindamycin?

    <p>Inhibition of protein synthesis similar to macrolides</p> Signup and view all the answers

    Which macrolide is known to cause prolongation of the QT interval?

    <p>Telithromycin</p> Signup and view all the answers

    What distinguishes ketolides like telithromycin from other macrolides?

    <p>Neutralize common resistance mechanisms and active against macrolide-resistant Gram-positive bacteria</p> Signup and view all the answers

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