18 Questions
What is the primary route of excretion for erythromycin?
Bile
Which of the following is a key pharmacokinetic advantage of clarithromycin over erythromycin?
Lower incidence of gastrointestinal side effects
Which of the following pathogens is azithromycin particularly effective against?
Chlamydia species
What is the primary mechanism of action for macrolide antibiotics like erythromycin?
Inhibition of protein synthesis
Which of the following is a common adverse effect associated with macrolide antibiotics?
Gastrointestinal intolerance
Which of the following is a key therapeutic use of erythromycin?
Treatment of corynebacterial infections
Which of the following is NOT a common adverse effect associated with macrolide antibiotics?
Hepatotoxicity
Which macrolide antibiotic has the broadest spectrum of activity against Gram-positive and Gram-negative organisms?
Azithromycin
What is the primary mechanism of action for macrolide antibiotics?
Binding to the 50S ribosomal subunit and inhibiting protein synthesis
Which of the following is NOT a common clinical use for macrolide antibiotics?
Treatment of malaria
What is the primary reason for the development of resistance to erythromycin, a macrolide antibiotic?
Modification of the ribosomal binding site
Which adverse effect is associated with the use of macrolide antibiotics in newborn infants?
Gray baby syndrome
Which of the following best describes the pharmacokinetics of macrolides?
Rapidly absorbed from the GI, widely distributed, and released slowly from tissues
What is a common side effect associated with macrolides?
Cholestatic hepatitis
Which macrolide is specifically active against penicillin- and erythromycin-resistant Streptococcus pneumoniae?
Telithromycin
What is the mechanism of action of clindamycin?
Inhibition of protein synthesis similar to macrolides
Which macrolide is known to cause prolongation of the QT interval?
Telithromycin
What distinguishes ketolides like telithromycin from other macrolides?
Neutralize common resistance mechanisms and active against macrolide-resistant Gram-positive bacteria
Test your knowledge on the pharmacokinetics and side effects of macrolide antibiotics. Learn about the absorption, distribution, metabolism, and excretion of macrolides, as well as common side effects such as epigastric discomfort, nausea, and prolonged QT interval.
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