19 protein synthesis inhibitor
18 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary route of excretion for erythromycin?

  • Feces
  • Urine
  • Bile (correct)
  • Sweat

Which of the following is a key pharmacokinetic advantage of clarithromycin over erythromycin?

  • Lower incidence of gastrointestinal side effects (correct)
  • Better acid stability
  • Longer half-life
  • Higher CSF penetration

Which of the following pathogens is azithromycin particularly effective against?

  • Anaerobic bacteria
  • Chlamydia species (correct)
  • Gram-positive bacteria
  • Gram-negative bacteria

What is the primary mechanism of action for macrolide antibiotics like erythromycin?

<p>Inhibition of protein synthesis (D)</p> Signup and view all the answers

Which of the following is a common adverse effect associated with macrolide antibiotics?

<p>Gastrointestinal intolerance (D)</p> Signup and view all the answers

Which of the following is a key therapeutic use of erythromycin?

<p>Treatment of corynebacterial infections (C)</p> Signup and view all the answers

Which of the following is NOT a common adverse effect associated with macrolide antibiotics?

<p>Hepatotoxicity (C)</p> Signup and view all the answers

Which macrolide antibiotic has the broadest spectrum of activity against Gram-positive and Gram-negative organisms?

<p>Azithromycin (B)</p> Signup and view all the answers

What is the primary mechanism of action for macrolide antibiotics?

<p>Binding to the 50S ribosomal subunit and inhibiting protein synthesis (D)</p> Signup and view all the answers

Which of the following is NOT a common clinical use for macrolide antibiotics?

<p>Treatment of malaria (A)</p> Signup and view all the answers

What is the primary reason for the development of resistance to erythromycin, a macrolide antibiotic?

<p>Modification of the ribosomal binding site (C)</p> Signup and view all the answers

Which adverse effect is associated with the use of macrolide antibiotics in newborn infants?

<p>Gray baby syndrome (B)</p> Signup and view all the answers

Which of the following best describes the pharmacokinetics of macrolides?

<p>Rapidly absorbed from the GI, widely distributed, and released slowly from tissues (A)</p> Signup and view all the answers

What is a common side effect associated with macrolides?

<p>Cholestatic hepatitis (D)</p> Signup and view all the answers

Which macrolide is specifically active against penicillin- and erythromycin-resistant Streptococcus pneumoniae?

<p>Telithromycin (A)</p> Signup and view all the answers

What is the mechanism of action of clindamycin?

<p>Inhibition of protein synthesis similar to macrolides (C)</p> Signup and view all the answers

Which macrolide is known to cause prolongation of the QT interval?

<p>Telithromycin (D)</p> Signup and view all the answers

What distinguishes ketolides like telithromycin from other macrolides?

<p>Neutralize common resistance mechanisms and active against macrolide-resistant Gram-positive bacteria (B)</p> Signup and view all the answers

More Like This

Pharmacokinetics Quiz
5 questions
Pharmacokinetics Overview
35 questions
Use Quizgecko on...
Browser
Browser