Podcast
Questions and Answers
Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?
Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?
- ALT
- Albumin (correct)
- GGT
- AST
Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?
Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?
- GGT
- Alkaline phosphatase
- AST
- ALT (correct)
Which classification system is used to classify the severity of cirrhosis based on a point system?
Which classification system is used to classify the severity of cirrhosis based on a point system?
- MELD score
- Child-Pugh Classification (correct)
- BCLC staging system
- Model for End-Stage Liver Disease
What does a Child-Pugh score of 5-6 indicate?
What does a Child-Pugh score of 5-6 indicate?
Which factor does the Child-Pugh Classification reflect?
Which factor does the Child-Pugh Classification reflect?
What does GGT indicate?
What does GGT indicate?
What does the presence of ascites indicate in the Child-Pugh Classification?
What does the presence of ascites indicate in the Child-Pugh Classification?
Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?
Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?
What do AST and ALT indicate?
What do AST and ALT indicate?
What does INR reflect in terms of liver function?
What does INR reflect in terms of liver function?
What can influence the levels of Albumin and INR?
What can influence the levels of Albumin and INR?
What does the MELD score reflect?
What does the MELD score reflect?
What do AST and ALT indicate?
What do AST and ALT indicate?
What does GGT indicate?
What does GGT indicate?
What does INR reflect in terms of liver function?
What does INR reflect in terms of liver function?
What does the MELD score reflect?
What does the MELD score reflect?
What does the presence of ascites indicate in the Child-Pugh Classification?
What does the presence of ascites indicate in the Child-Pugh Classification?
Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?
Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?
Which factor does the Child-Pugh Classification reflect?
Which factor does the Child-Pugh Classification reflect?
What does a Child-Pugh score of 5-6 indicate?
What does a Child-Pugh score of 5-6 indicate?
Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?
Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?
What can influence the levels of Albumin and INR?
What can influence the levels of Albumin and INR?
Which classification system is used to classify the severity of cirrhosis based on a point system?
Which classification system is used to classify the severity of cirrhosis based on a point system?
Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?
Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?
Which drug would be expected to have increased bioavailability in a patient with cirrhosis?
Which drug would be expected to have increased bioavailability in a patient with cirrhosis?
Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?
Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?
Which enzyme activity is greatly affected by liver dysfunction compared to others?
Which enzyme activity is greatly affected by liver dysfunction compared to others?
What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?
What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?
Which drug class may require a larger loading dose due to increased volume of distribution in patients with liver dysfunction?
Which drug class may require a larger loading dose due to increased volume of distribution in patients with liver dysfunction?
Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?
Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?
Which drug is an example of an intermediate extraction drug less sensitive to blood flow changes?
Which drug is an example of an intermediate extraction drug less sensitive to blood flow changes?
Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?
Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?
Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?
Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?
Which drug monitoring approach is recommended for low extraction drugs in patients with liver dysfunction?
Which drug monitoring approach is recommended for low extraction drugs in patients with liver dysfunction?
Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?
Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?
Which enzyme activity becomes worse as liver function worsens in patients with chronic liver disease?
Which enzyme activity becomes worse as liver function worsens in patients with chronic liver disease?
Which enzyme activity is greatly affected by liver dysfunction compared to others?
Which enzyme activity is greatly affected by liver dysfunction compared to others?
Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?
Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?
What does the presence of ascites indicate in the Child-Pugh Classification?
What does the presence of ascites indicate in the Child-Pugh Classification?
Which factor does the Child-Pugh Classification reflect?
Which factor does the Child-Pugh Classification reflect?
What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?
What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?
Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?
Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?
Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?
Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?
Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?
Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?
What does the MELD score reflect?
What does the MELD score reflect?
Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?
Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?
Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?
Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?
Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?
Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?
