Pharmacokinetic Considerations in Hepatic Dysfunction Quiz
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Questions and Answers

Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

  • ALT
  • Albumin (correct)
  • GGT
  • AST
  • Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?

  • GGT
  • Alkaline phosphatase
  • AST
  • ALT (correct)
  • Which classification system is used to classify the severity of cirrhosis based on a point system?

  • MELD score
  • Child-Pugh Classification (correct)
  • BCLC staging system
  • Model for End-Stage Liver Disease
  • What does a Child-Pugh score of 5-6 indicate?

    <p>Class A (mild)</p> Signup and view all the answers

    Which factor does the Child-Pugh Classification reflect?

    <p>Severity of cirrhosis</p> Signup and view all the answers

    What does GGT indicate?

    <p>Liver damage</p> Signup and view all the answers

    What does the presence of ascites indicate in the Child-Pugh Classification?

    <p>Class C (severe)</p> Signup and view all the answers

    Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

    <p>GGT</p> Signup and view all the answers

    What do AST and ALT indicate?

    <p>Liver damage</p> Signup and view all the answers

    What does INR reflect in terms of liver function?

    <p>Capability of the liver to clot blood</p> Signup and view all the answers

    What can influence the levels of Albumin and INR?

    <p>Other conditions</p> Signup and view all the answers

    What does the MELD score reflect?

    <p>Severity of cirrhosis</p> Signup and view all the answers

    What do AST and ALT indicate?

    <p>Liver damage</p> Signup and view all the answers

    What does GGT indicate?

    <p>Liver damage</p> Signup and view all the answers

    What does INR reflect in terms of liver function?

    <p>Liver synthetic function</p> Signup and view all the answers

    What does the MELD score reflect?

    <p>Severity of cirrhosis</p> Signup and view all the answers

    What does the presence of ascites indicate in the Child-Pugh Classification?

    <p>Severity of cirrhosis</p> Signup and view all the answers

    Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

    <p>Albumin and INR</p> Signup and view all the answers

    Which factor does the Child-Pugh Classification reflect?

    <p>Severity of cirrhosis</p> Signup and view all the answers

    What does a Child-Pugh score of 5-6 indicate?

    <p>Mild cirrhosis</p> Signup and view all the answers

    Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?

    <p>AST/ALT</p> Signup and view all the answers

    What can influence the levels of Albumin and INR?

    <p>Other conditions</p> Signup and view all the answers

    Which classification system is used to classify the severity of cirrhosis based on a point system?

    <p>Child-Pugh Classification</p> Signup and view all the answers

    Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

    <p>GGT</p> Signup and view all the answers

    Which drug would be expected to have increased bioavailability in a patient with cirrhosis?

    <p>Morphine</p> Signup and view all the answers

    Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?

    <p>Low extraction drugs</p> Signup and view all the answers

    Which enzyme activity is greatly affected by liver dysfunction compared to others?

    <p>CYP2C19</p> Signup and view all the answers

    What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?

    <p>Reduced muscle mass</p> Signup and view all the answers

    Which drug class may require a larger loading dose due to increased volume of distribution in patients with liver dysfunction?

    <p>Water-soluble drugs</p> Signup and view all the answers

    Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?

    <p>Promethazine</p> Signup and view all the answers

    Which drug is an example of an intermediate extraction drug less sensitive to blood flow changes?

    <p>Azathioprine</p> Signup and view all the answers

    Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?

    <p>Antineoplastic &amp; immunosuppressive agents</p> Signup and view all the answers

    Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?

    <p>Nitroglycerin</p> Signup and view all the answers

    Which drug monitoring approach is recommended for low extraction drugs in patients with liver dysfunction?

    <p>Use free concentration for drug monitoring</p> Signup and view all the answers

    Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?

    <p>Beta blockers</p> Signup and view all the answers

    Which enzyme activity becomes worse as liver function worsens in patients with chronic liver disease?

    <p>CYP2E1</p> Signup and view all the answers

    Which enzyme activity is greatly affected by liver dysfunction compared to others?

    <p>CYP2C19</p> Signup and view all the answers

    Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?

    <p>Beta Blockers</p> Signup and view all the answers

    What does the presence of ascites indicate in the Child-Pugh Classification?

    <p>Severe liver disease</p> Signup and view all the answers

    Which factor does the Child-Pugh Classification reflect?

    <p>Severity of liver cirrhosis</p> Signup and view all the answers

    What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?

    <p>Reduced muscle mass</p> Signup and view all the answers

    Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?

    <p>Morphine</p> Signup and view all the answers

    Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

    <p>Albumin</p> Signup and view all the answers

    Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?

    <p>Antineoplastic &amp; Immunosuppressive Agents</p> Signup and view all the answers

    What does the MELD score reflect?

    <p>Severity of liver cirrhosis</p> Signup and view all the answers

    Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

    <p>ALT</p> Signup and view all the answers

    Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?

    <p>Verapamil</p> Signup and view all the answers

    Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?

    <p>Low extraction drugs</p> Signup and view all the answers

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