Pharmacokinetic Considerations in Hepatic Dysfunction Quiz

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Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

ALT

Albumin (correct)

GGT

AST

Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?

GGT

Alkaline phosphatase

AST

ALT (correct)

Which classification system is used to classify the severity of cirrhosis based on a point system?

MELD score

Child-Pugh Classification (correct)

BCLC staging system

Model for End-Stage Liver Disease

What does a Child-Pugh score of 5-6 indicate?

Class A (mild) Signup and view all the answers

Which factor does the Child-Pugh Classification reflect?

Severity of cirrhosis Signup and view all the answers

What does GGT indicate?

Liver damage Signup and view all the answers

What does the presence of ascites indicate in the Child-Pugh Classification?

Class C (severe) Signup and view all the answers

Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

GGT Signup and view all the answers

What do AST and ALT indicate?

Liver damage Signup and view all the answers

What does INR reflect in terms of liver function?

Capability of the liver to clot blood Signup and view all the answers

What can influence the levels of Albumin and INR?

Other conditions Signup and view all the answers

What does the MELD score reflect?

Severity of cirrhosis Signup and view all the answers

What do AST and ALT indicate?

Liver damage Signup and view all the answers

What does GGT indicate?

Liver damage Signup and view all the answers

What does INR reflect in terms of liver function?

Liver synthetic function Signup and view all the answers

What does the MELD score reflect?

Severity of cirrhosis Signup and view all the answers

What does the presence of ascites indicate in the Child-Pugh Classification?

Severity of cirrhosis Signup and view all the answers

Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

Albumin and INR Signup and view all the answers

Which factor does the Child-Pugh Classification reflect?

Severity of cirrhosis Signup and view all the answers

What does a Child-Pugh score of 5-6 indicate?

Mild cirrhosis Signup and view all the answers

Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?

AST/ALT Signup and view all the answers

What can influence the levels of Albumin and INR?

Other conditions Signup and view all the answers

Which classification system is used to classify the severity of cirrhosis based on a point system?

Child-Pugh Classification Signup and view all the answers

Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

GGT Signup and view all the answers

Which drug would be expected to have increased bioavailability in a patient with cirrhosis?

Morphine Signup and view all the answers

Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?

Low extraction drugs Signup and view all the answers

Which enzyme activity is greatly affected by liver dysfunction compared to others?

CYP2C19 Signup and view all the answers

What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?

Reduced muscle mass Signup and view all the answers

Which drug class may require a larger loading dose due to increased volume of distribution in patients with liver dysfunction?

Water-soluble drugs Signup and view all the answers

Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?

Promethazine Signup and view all the answers

Which drug is an example of an intermediate extraction drug less sensitive to blood flow changes?

Azathioprine Signup and view all the answers

Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?

Antineoplastic & immunosuppressive agents Signup and view all the answers

Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?

Nitroglycerin Signup and view all the answers

Which drug monitoring approach is recommended for low extraction drugs in patients with liver dysfunction?

Use free concentration for drug monitoring Signup and view all the answers

Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?

Beta blockers Signup and view all the answers

Which enzyme activity becomes worse as liver function worsens in patients with chronic liver disease?

CYP2E1 Signup and view all the answers

Which enzyme activity is greatly affected by liver dysfunction compared to others?

CYP2C19 Signup and view all the answers

Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?

Beta Blockers Signup and view all the answers

What does the presence of ascites indicate in the Child-Pugh Classification?

Severe liver disease Signup and view all the answers

Which factor does the Child-Pugh Classification reflect?

Severity of liver cirrhosis Signup and view all the answers

What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?

Reduced muscle mass Signup and view all the answers

Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?

Morphine Signup and view all the answers

Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

Albumin Signup and view all the answers

Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?

Antineoplastic & Immunosuppressive Agents Signup and view all the answers

What does the MELD score reflect?

Severity of liver cirrhosis Signup and view all the answers

Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

ALT Signup and view all the answers

Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?

Verapamil Signup and view all the answers

Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?

Low extraction drugs Signup and view all the answers

Pharmacokinetic Considerations in Hepatic Dysfunction Quiz

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Questions and Answers

Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?

Which classification system is used to classify the severity of cirrhosis based on a point system?

What does a Child-Pugh score of 5-6 indicate?

Which factor does the Child-Pugh Classification reflect?

What does GGT indicate?

What does the presence of ascites indicate in the Child-Pugh Classification?

Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

What do AST and ALT indicate?

What does INR reflect in terms of liver function?

What can influence the levels of Albumin and INR?

What does the MELD score reflect?

What do AST and ALT indicate?

What does GGT indicate?

What does INR reflect in terms of liver function?

What does the MELD score reflect?

What does the presence of ascites indicate in the Child-Pugh Classification?

Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

Which factor does the Child-Pugh Classification reflect?

What does a Child-Pugh score of 5-6 indicate?

Which traditional liver function test is an indication of liver damage, but not the ability of the liver to metabolize drugs?

What can influence the levels of Albumin and INR?

Which classification system is used to classify the severity of cirrhosis based on a point system?

Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

Which drug would be expected to have increased bioavailability in a patient with cirrhosis?

Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?

Which enzyme activity is greatly affected by liver dysfunction compared to others?

What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?

Which drug class may require a larger loading dose due to increased volume of distribution in patients with liver dysfunction?

Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?

Which drug is an example of an intermediate extraction drug less sensitive to blood flow changes?

Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?

Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?

Which drug monitoring approach is recommended for low extraction drugs in patients with liver dysfunction?

Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?

Which enzyme activity becomes worse as liver function worsens in patients with chronic liver disease?

Which enzyme activity is greatly affected by liver dysfunction compared to others?

Which drug class may be less sensitive to natriuretic effects of loop diuretics in patients with chronic liver disease?

What does the presence of ascites indicate in the Child-Pugh Classification?

Which factor does the Child-Pugh Classification reflect?

What can cause an overestimation of glomerular filtration rate (GFR) when using serum creatinine for calculations in patients with chronic liver disease?

Which drug is more susceptible to alterations in blood flow due to decreased hepatic clearance in patients with chronic liver disease?

Which liver function test reflects the capability of the liver to synthesize proteins and likely drug metabolizing enzymes?

Which drug class is more affected by liver dysfunction due to increased water solubility for renal excretion?

What does the MELD score reflect?

Which liver function test reflects the destruction of the liver’s vascular and lobular architecture?

Which drug may require maintenance dose reduction in patients with chronic liver disease due to decreased hepatic clearance?

Which type of drug is less sensitive to changes in blood flow and may require a normal initial dose but reduced maintenance dose in patients with chronic liver disease?

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