23 Questions
What is the main process of dosage optimization for an individual patient currently?
Using a trial and error method
Which of the following is NOT a potential benefit of pharmacogenomics (PGx)?
Increasing the chances of adverse drug reactions (ADRs) to prescription drugs
What percentage of drugs are metabolized by CYP2D6?
25%
Which enzyme subtype is associated with altered drug response for warfarin?
CYP2C9
Which phenotype may suffer from adverse drug reactions (ADRs) at the usual doses of drugs with narrow therapeutic index?
Poor metabolizer (PM)
What is the definition of pharmacogenomics?
The study of the relationship between variants in a large collection of genes and drug effects
What is the difference between pharmacogenetics and pharmacogenomics?
Pharmacogenetics studies individual gene variants, while pharmacogenomics studies a large collection of genes
What is the role of PGX in personalizing healthcare?
Analyzing genetic factors to tailor medical treatments to individual patients
How would you define PGX?
The analysis of genetic factors that determine drug efficacy and toxicity
What is the future potential of pharmacogenomic testing according to Youssef et al (2020)?
To enhance the role of community pharmacies in personalized medicine
Which term refers to the study of the relationship between individual gene variants and drug effects?
Pharmacogenetics
What is the molecular study of genetic factors that determine drug efficacy and toxicity called?
Pharmacogenomics
What is a potential future application of pharmacogenomic testing according to Youssef et al (2020)?
Customized drug therapy
What is the main focus of pharmacogenomics?
Examining the influence of genetic factors on drug response
Which enzyme subtype is commonly associated with altered drug response for many medications?
CYP2D6
What percentage of drugs are estimated to be metabolized by the CYP2D6 enzyme subtype?
50%
What is the main process of dosage optimization for an individual patient currently?
Trial and error
Which factor influences an individual's response to a drug by identifying people likely to respond?
Genetic factors
What percentage of drugs are metabolized by CYP2D6?
25%
What is the most common major adverse drug reaction (ADR) mentioned in the text?
Cardiovascular
Which enzyme subtype is associated with altered drug response for warfarin?
CYP2C9
What is the potential benefit of adjusting dose to PK genotype?
Uniform drug exposure to reduce dose-dependent ADRs
What is the prevalence of the poor and intermediate metabolizer phenotype in different populations?
5-10%
This quiz covers essential reading materials related to individual variation, pharmacogenomics, and personalized medicine. It includes key articles by Roden et al and Youssef et al, focusing on pharmacogenomic testing and its future in community pharmacy. The quiz is designed to assess your understanding of the essential concepts in pharmacogenomics.
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