Pharmacogenomics Essential Reading Section 1

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What is the main process of dosage optimization for an individual patient currently?

Employing a personalized medicine approach

Administering a fixed dose for all patients

Using a trial and error method (correct)

Applying pharmacogenetics to predict drug response

Which of the following is NOT a potential benefit of pharmacogenomics (PGx)?

Identifying promising drugs in the pharmaceutical pipeline that show ADRs in certain groups of the population may be saved

Increasing the chances of adverse drug reactions (ADRs) to prescription drugs (correct)

Minimizing adverse drug reactions (ADRs) by predicting people at risk

Preventing therapeutic failure when efficacy cannot be immediately assessed

What percentage of drugs are metabolized by CYP2D6?

25% (correct)

44%

5%

10%

Which enzyme subtype is associated with altered drug response for warfarin?

CYP2C9 (B) Signup and view all the answers

Which phenotype may suffer from adverse drug reactions (ADRs) at the usual doses of drugs with narrow therapeutic index?

Poor metabolizer (PM) (C) Signup and view all the answers

What is the definition of pharmacogenomics?

The study of the relationship between variants in a large collection of genes and drug effects (D) Signup and view all the answers

What is the difference between pharmacogenetics and pharmacogenomics?

Pharmacogenetics studies individual gene variants, while pharmacogenomics studies a large collection of genes (B) Signup and view all the answers

What is the role of PGX in personalizing healthcare?

Analyzing genetic factors to tailor medical treatments to individual patients (A) Signup and view all the answers

How would you define PGX?

The analysis of genetic factors that determine drug efficacy and toxicity (C) Signup and view all the answers

What is the future potential of pharmacogenomic testing according to Youssef et al (2020)?

To enhance the role of community pharmacies in personalized medicine (A) Signup and view all the answers

Which term refers to the study of the relationship between individual gene variants and drug effects?

Pharmacogenetics (D) Signup and view all the answers

What is the molecular study of genetic factors that determine drug efficacy and toxicity called?

Pharmacogenomics (B) Signup and view all the answers

What is a potential future application of pharmacogenomic testing according to Youssef et al (2020)?

Customized drug therapy (C) Signup and view all the answers

What is the main focus of pharmacogenomics?

Examining the influence of genetic factors on drug response (A) Signup and view all the answers

Which enzyme subtype is commonly associated with altered drug response for many medications?

CYP2D6 (D) Signup and view all the answers

What percentage of drugs are estimated to be metabolized by the CYP2D6 enzyme subtype?

50% (D) Signup and view all the answers

What is the main process of dosage optimization for an individual patient currently?

Trial and error (D) Signup and view all the answers

Which factor influences an individual's response to a drug by identifying people likely to respond?

Genetic factors (D) Signup and view all the answers

What percentage of drugs are metabolized by CYP2D6?

25% (D) Signup and view all the answers

What is the most common major adverse drug reaction (ADR) mentioned in the text?

Cardiovascular (A) Signup and view all the answers

Which enzyme subtype is associated with altered drug response for warfarin?

CYP2C9 (C) Signup and view all the answers

What is the potential benefit of adjusting dose to PK genotype?

Uniform drug exposure to reduce dose-dependent ADRs (D) Signup and view all the answers

What is the prevalence of the poor and intermediate metabolizer phenotype in different populations?

5-10% (D) Signup and view all the answers

Pharmacogenomics Essential Reading Section 1

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Questions and Answers

What is the main process of dosage optimization for an individual patient currently?

Which of the following is NOT a potential benefit of pharmacogenomics (PGx)?

What percentage of drugs are metabolized by CYP2D6?

Which enzyme subtype is associated with altered drug response for warfarin?

Which phenotype may suffer from adverse drug reactions (ADRs) at the usual doses of drugs with narrow therapeutic index?

What is the definition of pharmacogenomics?

What is the difference between pharmacogenetics and pharmacogenomics?

What is the role of PGX in personalizing healthcare?

How would you define PGX?

What is the future potential of pharmacogenomic testing according to Youssef et al (2020)?

Which term refers to the study of the relationship between individual gene variants and drug effects?

What is the molecular study of genetic factors that determine drug efficacy and toxicity called?

What is a potential future application of pharmacogenomic testing according to Youssef et al (2020)?

What is the main focus of pharmacogenomics?

Which enzyme subtype is commonly associated with altered drug response for many medications?

What percentage of drugs are estimated to be metabolized by the CYP2D6 enzyme subtype?

What is the main process of dosage optimization for an individual patient currently?

Which factor influences an individual's response to a drug by identifying people likely to respond?

What percentage of drugs are metabolized by CYP2D6?

What is the most common major adverse drug reaction (ADR) mentioned in the text?

Which enzyme subtype is associated with altered drug response for warfarin?

What is the potential benefit of adjusting dose to PK genotype?

What is the prevalence of the poor and intermediate metabolizer phenotype in different populations?

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