Pharmacogenomics Essential Reading Section 1
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Questions and Answers

What is the main process of dosage optimization for an individual patient currently?

  • Employing a personalized medicine approach
  • Administering a fixed dose for all patients
  • Using a trial and error method (correct)
  • Applying pharmacogenetics to predict drug response

    • Which of the following is NOT a potential benefit of pharmacogenomics (PGx)?

  • Identifying promising drugs in the pharmaceutical pipeline that show ADRs in certain groups of the population may be saved
  • Increasing the chances of adverse drug reactions (ADRs) to prescription drugs (correct)
  • Minimizing adverse drug reactions (ADRs) by predicting people at risk
  • Preventing therapeutic failure when efficacy cannot be immediately assessed

    • What percentage of drugs are metabolized by CYP2D6?

  • 25% (correct)
  • 44%
  • 5%
  • 10%

    • Which enzyme subtype is associated with altered drug response for warfarin?

    <p>CYP2C9</p> Signup and view all the answers

    Which phenotype may suffer from adverse drug reactions (ADRs) at the usual doses of drugs with narrow therapeutic index?

    <p>Poor metabolizer (PM)</p> Signup and view all the answers

    What is the definition of pharmacogenomics?

    <p>The study of the relationship between variants in a large collection of genes and drug effects</p> Signup and view all the answers

    What is the difference between pharmacogenetics and pharmacogenomics?

    <p>Pharmacogenetics studies individual gene variants, while pharmacogenomics studies a large collection of genes</p> Signup and view all the answers

    What is the role of PGX in personalizing healthcare?

    <p>Analyzing genetic factors to tailor medical treatments to individual patients</p> Signup and view all the answers

    How would you define PGX?

    <p>The analysis of genetic factors that determine drug efficacy and toxicity</p> Signup and view all the answers

    What is the future potential of pharmacogenomic testing according to Youssef et al (2020)?

    <p>To enhance the role of community pharmacies in personalized medicine</p> Signup and view all the answers

    Which term refers to the study of the relationship between individual gene variants and drug effects?

    <p>Pharmacogenetics</p> Signup and view all the answers

    What is the molecular study of genetic factors that determine drug efficacy and toxicity called?

    <p>Pharmacogenomics</p> Signup and view all the answers

    What is a potential future application of pharmacogenomic testing according to Youssef et al (2020)?

    <p>Customized drug therapy</p> Signup and view all the answers

    What is the main focus of pharmacogenomics?

    <p>Examining the influence of genetic factors on drug response</p> Signup and view all the answers

    Which enzyme subtype is commonly associated with altered drug response for many medications?

    <p>CYP2D6</p> Signup and view all the answers

    What percentage of drugs are estimated to be metabolized by the CYP2D6 enzyme subtype?

    <p>50%</p> Signup and view all the answers

    What is the main process of dosage optimization for an individual patient currently?

    <p>Trial and error</p> Signup and view all the answers

    Which factor influences an individual's response to a drug by identifying people likely to respond?

    <p>Genetic factors</p> Signup and view all the answers

    What percentage of drugs are metabolized by CYP2D6?

    <p>25%</p> Signup and view all the answers

    What is the most common major adverse drug reaction (ADR) mentioned in the text?

    <p>Cardiovascular</p> Signup and view all the answers

    Which enzyme subtype is associated with altered drug response for warfarin?

    <p>CYP2C9</p> Signup and view all the answers

    What is the potential benefit of adjusting dose to PK genotype?

    <p>Uniform drug exposure to reduce dose-dependent ADRs</p> Signup and view all the answers

    What is the prevalence of the poor and intermediate metabolizer phenotype in different populations?

    <p>5-10%</p> Signup and view all the answers

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