Pharmacogenomics

What is the main focus of pharmacogenetics?

What is the primary concern of pharmacogenomics?

Why is the genotype to phenotype approach important in drug response?

What is a significant factor contributing to the variability in drug response among individuals?

What does the PGxOne test provide insight into?

What is the primary cause of the deficiency of glucose-6-phosphate dehydrogenase (G6PD) in the blood?

Which group is more commonly affected by the deficiency of G6PD?

Which of the following medications should individuals with G6PD deficiency avoid?

What are SNPs?

What is the association between VKORC1 variant and warfarin sensitivity?

Which enzymatic variant is not associated with warfarin sensitivity and requires a lower warfarin dose?

For the gene mutation VKORC1*1, what does "VKORC1" indicate?

For the gene mutation VKORC1*1, what does "*1" indicate?

For the gene mutation VKORC1*2, what does "*2" indicate?

For the gene mutation VKORC1*3, what does "*3" indicate?

What percentage of drugs are at least partially metabolized by the CYP2D6 enzyme?

How many alleles of the CYP2D6 enzyme are currently identified?

Which type of drugs are metabolized by the CYP2D6 enzyme that was listed in the PowerPoint?

What are haplotypes in the context of genetics?

How are CYP2D6 haplotypes defined?

What type of metabolism does an extensive metabolizer have?

How would you describe the metabolism of an intermediate metabolizer?