10 Questions
What is the primary function of dimercaprol?
To bind to heavy metals like arsenic and lead
What is the effect of pharmacokinetic antagonists on the agonist?
Decrease the concentration of the agonist at the site of action
How do pharmacological antagonists interact with the receptor?
By binding to the receptor in a similar fashion to agonists
What is the mechanism of orthosteric antagonism?
The antagonist binds to the same site as the agonist
What determines the potency of an antagonist?
The affinity of the antagonist for the target protein
What is the effect of allosteric antagonism on the receptor?
The antagonist alters the conformation of the receptor
What is the primary difference between agonist and antagonist potency?
Agonist potency is cell-dependent, while antagonist potency is not
What is the effect of pharmacological antagonists on the agonist's response?
They antagonize the effects of the agonist
What are the three factors that influence the extent of antagonism?
Potency, mechanism, and kinetics
What is the primary difference between physiological and pharmacological antagonists?
Physiological antagonists stimulate a response that opposes the agonist's action, while pharmacological antagonists bind to the receptor
Test your knowledge of receptor theory, efficacy, and spare receptors in pharmacodynamics. Learn about the concepts developed by Prof. Arthur Butt Stephenson and how they differ from Clark's occupation theory.
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