Pharmacodynamics Overview

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the definition of pharmacodynamics?

Pharmacodynamics is the study of the biochemical and physiological effects of drugs on the body, and the mechanisms by which these effects are produced.

What are two main mechanisms of drug action?

  • Receptor mediated and non-receptor mediated (correct)
  • Hormonal and non-hormonal
  • Receptor-mediated and cellular-mediated
  • Physical and chemical

A receptor is a specific cellular structure, usually a protein, that binds a ligand. Ligands can include drugs, hormones and neurotransmitters.

True (A)

Match the types of ligands with their definitions.

<p>Agonist = A ligand that binds to a receptor and activates it, producing a biological response. Antagonist = A ligand that binds to a receptor but does not activate it. Instead, it blocks the action of an agonist. Partial agonist = A ligand that binds to a receptor and activates it, but produces a weaker response than a full agonist. Ligand = Any molecule that binds to a receptor.</p> Signup and view all the answers

What are two factors that influence a ligand's ability to bind to a receptor?

<p>Affinity and Efficacy (B)</p> Signup and view all the answers

An antagonist blocks an agonist's effect on the receptor.

<p>True (A)</p> Signup and view all the answers

What are the two types of antagonists?

<p>Competitive antagonists and Non-competitive antagonists (B)</p> Signup and view all the answers

What is a competitive antagonist?

<p>A competitive antagonist binds to the same site on the receptor as the agonist but does not activate the receptor. It competes with the agonist for binding sites on the receptor.</p> Signup and view all the answers

What is a pharmacological antagonist?

<p>A pharmacological antagonist acts on the same receptor as the agonist, competing with the agonist for binding sites.</p> Signup and view all the answers

What is a chemical antagonist?

<p>A chemical antagonist interacts directly with the agonist, preventing it from reaching the receptor.</p> Signup and view all the answers

What are some examples of drugs that act by physical means?

<p>Demulcents (e.g., bismuth salts), adsorbents (e.g., charcoal), and lubricants (e.g., liquid paraffin) are examples of drugs that act by physical means.</p> Signup and view all the answers

What is chelation?

<p>Chelation is the ability of a drug to form a complex with a metal ion, effectively inactivating and excreting the metal from the body.</p> Signup and view all the answers

Flashcards

Pharmacodynamics

The study of how drugs interact with the body to produce their effects.

Mechanism of Drug Action

The specific way a drug interacts with its target molecule in the body to elicit its effects.

Receptor Mediated Mechanism

A process by which a drug interacts with a receptor, producing a response, usually leading to a therapeutic or physiological effect.

Non-Receptor Mediated Mechanism

A process by which a drug exerts its effect without directly interacting with a specific receptor.

Signup and view all the flashcards

Affinity

The ability of a drug to bind to a receptor.

Signup and view all the flashcards

Efficacy

The ability of a drug to activate its target receptor and produce a response.

Signup and view all the flashcards

Agonist

A drug that binds to a receptor and activates it, producing a response.

Signup and view all the flashcards

Antagonist

A drug that binds to a receptor and blocks its activation, preventing a response.

Signup and view all the flashcards

Partial Agonist

A drug that binds to a receptor and partially activates it, producing a weaker response compared to a full agonist.

Signup and view all the flashcards

Competitive Antagonist

An antagonist that binds to the same site as the agonist, preventing the agonist from binding and activating the receptor.

Signup and view all the flashcards

Noncompetitive Antagonist

An antagonist that binds to a different site than the agonist, but still prevents the agonist from effectively activating the receptor.

Signup and view all the flashcards

Competitive Antagonism

A type of drug interaction where two drugs compete for the same receptor binding site.

Signup and view all the flashcards

Noncompetitive Antagonism

A type of drug interaction where one drug binds to the receptor in a way that cannot be overcome by increasing agonist concentration.

Signup and view all the flashcards

Pharmacological Antagonist

A type of antagonist that binds to a receptor and blocks its activation by an agonist.

Signup and view all the flashcards

Chemical Antagonist

A type of antagonist that interacts chemically with the agonist, inactivating it and preventing it from reaching the receptor.

Signup and view all the flashcards

Physiological Antagonist

A type of antagonist that acts on a different pathway than the agonist, but ultimately produces a counteracting effect.

Signup and view all the flashcards

Demulcents

Drugs that coat and soothe irritated tissues, providing relief.

Signup and view all the flashcards

Adsorbents

Drugs that absorb toxins, gases, or other substances in the body.

Signup and view all the flashcards

Lubricants

Drugs that reduce friction and facilitate the movement of substances within the body.

Signup and view all the flashcards

Antacids

Drugs that neutralize acids, often used in the treatment of acid reflux or peptic ulcer disease.

Signup and view all the flashcards

Chelation

A process in which a substance binds to a metal ion, rendering it inactive and allowing for easier excretion from the body.

Signup and view all the flashcards

Chelating Agents

Drugs that bind to metal ions and facilitate their removal from the body, often used in the treatment of metal poisoning.

Signup and view all the flashcards

Potency

The measure of the drug's concentration needed to produce a specific response.

Signup and view all the flashcards

Dose-Response Curve

A graphic representation of the relationship between drug dose and its effect, showing the range of responses from a minimal to maximal effect.

Signup and view all the flashcards

Efficacy

The maximum effect a drug can produce, regardless of the dose.

Signup and view all the flashcards

Intrinsic Activity

A term used to describe the ability of a drug to activate its target receptor and produce a response.

Signup and view all the flashcards

Study Notes

Pharmacodynamics 1

  • Pharmacodynamics studies the drug's effect on the body
  • It's the relationship between drug concentration and the resulting biological effect.
  • The body and the drug interact in a cycle
  • Pharmacodynamics is distinct from pharmacokinetics, which describes how the body absorbs, distributes, metabolizes, and excretes a drug.

Drug Action

  • Mechanism of drug action is outlined
  • Including receptor-mediated and non-receptor-mediated mechanisms.
  • Types include Receptor-mediated, Non-receptor mediated, Pharmacological antagonists, Competitive antagonists
  • Non-competitive antagonists, Chemical antagonists, Physiological antagonists

Receptor-Mediated Mechanisms

  • Specific cellular structure (protein) binds to ligand (drug).
  • Ligand binding results in a response (action).
  • Ligands include agonists, partial agonists, and antagonists.

Ligands

  • Active part of drug
  • Binding to receptor results in response
  • Agonist—stimulates a response
  • Partial agonist—intermediate effect
  • Antagonist—blocks a response
  • Affinity measures binding ability
  • Efficacy measures response activation ability

Antagonism

  • Competitive antagonists compete with agonists for receptor sites.
  • Non-competitive antagonists bind to different sites, impeding agonist activity.

Types of Antagonism

  • Competitive antagonism—antagonist competes for receptor sites.
  • Non-competitive antagonism—antagonist binds to a different site, preventing action.
  • Chemical antagonism—antagonists neutralize a substance directly.
  • Physiological antagonism—antagonistic effects from separate mechanisms

Dose-Response Curves

  • Shows drug response versus dosage.
  • Important for understanding drug potency and efficacy.

Drugs Acting by Physical Means

  • Demulcents soothe tissue—Examples: bismuth salts coat the gastric mucosa.
  • Adsorbents absorb substances—Examples: charcoal adsorbs gases and toxins.
  • Lubricants allow easier movement—Examples: liquid paraffin lubricates.

Drugs Acting by Chemical Means

  • Antacids neutralize—Examples: neutralize stomach acid (HCl) in peptic ulcers.
  • Chemical Interactions—Examples: Protamine neutralizes heparin, an anticoagulant.

Chelation

  • Drugs to produce complex with metals to inactivate and excrete metal.
  • Used in treatment of metal poisoning.
  • Examples: Desferrioxamine treats iron poisoning, penicillamine treats copper poisoning (Wilson's disease).

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Pharmacology Ch 2 Pharmacodynamics
79 questions
Pharmacodynamics and Drug Action
10 questions

Pharmacodynamics and Drug Action

WellInformedExpressionism6426 avatar
WellInformedExpressionism6426
Pharmacodynamics Quiz
42 questions

Pharmacodynamics Quiz

ReverentCynicalRealism7855 avatar
ReverentCynicalRealism7855
Use Quizgecko on...
Browser
Browser