Podcast
Questions and Answers
What is the definition of pharmacodynamics?
What is the definition of pharmacodynamics?
Pharmacodynamics is the study of the biochemical and physiological effects of drugs on the body, and the mechanisms by which these effects are produced.
What are two main mechanisms of drug action?
What are two main mechanisms of drug action?
- Receptor mediated and non-receptor mediated (correct)
- Hormonal and non-hormonal
- Receptor-mediated and cellular-mediated
- Physical and chemical
A receptor is a specific cellular structure, usually a protein, that binds a ligand. Ligands can include drugs, hormones and neurotransmitters.
A receptor is a specific cellular structure, usually a protein, that binds a ligand. Ligands can include drugs, hormones and neurotransmitters.
True (A)
Match the types of ligands with their definitions.
Match the types of ligands with their definitions.
What are two factors that influence a ligand's ability to bind to a receptor?
What are two factors that influence a ligand's ability to bind to a receptor?
An antagonist blocks an agonist's effect on the receptor.
An antagonist blocks an agonist's effect on the receptor.
What are the two types of antagonists?
What are the two types of antagonists?
What is a competitive antagonist?
What is a competitive antagonist?
What is a pharmacological antagonist?
What is a pharmacological antagonist?
What is a chemical antagonist?
What is a chemical antagonist?
What are some examples of drugs that act by physical means?
What are some examples of drugs that act by physical means?
What is chelation?
What is chelation?
Flashcards
Pharmacodynamics
Pharmacodynamics
The study of how drugs interact with the body to produce their effects.
Mechanism of Drug Action
Mechanism of Drug Action
The specific way a drug interacts with its target molecule in the body to elicit its effects.
Receptor Mediated Mechanism
Receptor Mediated Mechanism
A process by which a drug interacts with a receptor, producing a response, usually leading to a therapeutic or physiological effect.
Non-Receptor Mediated Mechanism
Non-Receptor Mediated Mechanism
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Affinity
Affinity
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Efficacy
Efficacy
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Agonist
Agonist
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Antagonist
Antagonist
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Partial Agonist
Partial Agonist
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Competitive Antagonist
Competitive Antagonist
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Noncompetitive Antagonist
Noncompetitive Antagonist
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Competitive Antagonism
Competitive Antagonism
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Noncompetitive Antagonism
Noncompetitive Antagonism
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Pharmacological Antagonist
Pharmacological Antagonist
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Chemical Antagonist
Chemical Antagonist
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Physiological Antagonist
Physiological Antagonist
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Demulcents
Demulcents
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Adsorbents
Adsorbents
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Lubricants
Lubricants
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Antacids
Antacids
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Chelation
Chelation
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Chelating Agents
Chelating Agents
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Potency
Potency
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Dose-Response Curve
Dose-Response Curve
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Efficacy
Efficacy
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Intrinsic Activity
Intrinsic Activity
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Study Notes
Pharmacodynamics 1
- Pharmacodynamics studies the drug's effect on the body
- It's the relationship between drug concentration and the resulting biological effect.
- The body and the drug interact in a cycle
- Pharmacodynamics is distinct from pharmacokinetics, which describes how the body absorbs, distributes, metabolizes, and excretes a drug.
Drug Action
- Mechanism of drug action is outlined
- Including receptor-mediated and non-receptor-mediated mechanisms.
- Types include Receptor-mediated, Non-receptor mediated, Pharmacological antagonists, Competitive antagonists
- Non-competitive antagonists, Chemical antagonists, Physiological antagonists
Receptor-Mediated Mechanisms
- Specific cellular structure (protein) binds to ligand (drug).
- Ligand binding results in a response (action).
- Ligands include agonists, partial agonists, and antagonists.
Ligands
- Active part of drug
- Binding to receptor results in response
- Agonist—stimulates a response
- Partial agonist—intermediate effect
- Antagonist—blocks a response
- Affinity measures binding ability
- Efficacy measures response activation ability
Antagonism
- Competitive antagonists compete with agonists for receptor sites.
- Non-competitive antagonists bind to different sites, impeding agonist activity.
Types of Antagonism
- Competitive antagonism—antagonist competes for receptor sites.
- Non-competitive antagonism—antagonist binds to a different site, preventing action.
- Chemical antagonism—antagonists neutralize a substance directly.
- Physiological antagonism—antagonistic effects from separate mechanisms
Dose-Response Curves
- Shows drug response versus dosage.
- Important for understanding drug potency and efficacy.
Drugs Acting by Physical Means
- Demulcents soothe tissue—Examples: bismuth salts coat the gastric mucosa.
- Adsorbents absorb substances—Examples: charcoal adsorbs gases and toxins.
- Lubricants allow easier movement—Examples: liquid paraffin lubricates.
Drugs Acting by Chemical Means
- Antacids neutralize—Examples: neutralize stomach acid (HCl) in peptic ulcers.
- Chemical Interactions—Examples: Protamine neutralizes heparin, an anticoagulant.
Chelation
- Drugs to produce complex with metals to inactivate and excrete metal.
- Used in treatment of metal poisoning.
- Examples: Desferrioxamine treats iron poisoning, penicillamine treats copper poisoning (Wilson's disease).
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