Pharmacodynamics 1 Lecture Notes PDF

Pharmacodynamics 1 Dr. Nesreen Elgayar  Pharmacodynamic Body Drug Dec 31, 2024 Pharmacokinetic  Outlines Pharmacodynamics. Mechanism of Drug Action Receptor Mediated. Non Receptor Mediated. Dec 31, 2024 ...

Pharmacodynamics 1 Dr. Nesreen Elgayar  Pharmacodynamic Body Drug Dec 31, 2024 Pharmacokinetic  Outlines Pharmacodynamics. Mechanism of Drug Action Receptor Mediated. Non Receptor Mediated. Dec 31, 2024  Pharmacodynamics Action of a Drug on the Body Dec 31, 2024  Pharmacodynami c (e.g. Aspirin( 1- Mechanism of action 2- Pharm. Actions 3- Indications (uses) 4- Adverse effects 5- Contraindications 6- Drug interactions Dec 31, 2024  Dose-Response Curves Dec 31, 2024  Pharmacodynamics Action of a Drug on the Body Dec 31, 2024  Mechanism of Drug Action Receptor- Non-Receptor- mediated mediated Dec 31, 2024  Receptor Mediated Mechanism Receptor Ligand Specific cellular structure, protein, binds ligand → Response Receptor Ligand Active part of drug Response binds Receptor → Response (Action) Dec 31, 2024  Ligand Antagon ist Agonis t Partial Agonist depending on :Affinity → Ability to bind with receptor Efficacy → Ability to Activate Dec 31, 2024  Ligand Affinity Receptor Efficacy Response (Action) Dec 31, 2024 Agonist Morphine Affinity R & Action Efficacy Dec 31, 2024  Buprenorphine Partial A PA Agonist Affinity R & Weak action Partial Efficacy (Agonistic) (Antagonistic) Dec 31, 2024  Naloxone Antagoni st Agonist Antagonist Affinity Receptor No Efficacy No Dec 31, 2024 Response  Antagoni st I- Competitive Antagonist II- Noncompetitive Antagonist Dec 31, 2024  I- Competitive Antagonist Agonist Antagonist Antagonist Receptor No Dec 31, 2024 Response  I- Competitive Antagonist Agonist Antagonist Agonist Antagonist Agonist Receptor Response + ++ (Action) ion ofDecAntagonism 31, 2024 depends on plasma conc. of Agonist & Antag  I- Competitive Antagonist 100 % 50 % e.g. (β-blocker) Propranolol Dec 31, 2024  II- Noncompetitive Antagonist Agonist Agonist Antagonist Agonist Receptor No Response ration Decof antagonism depends on rate of Turnover of the Recep 31, 2024  II- Noncompetitive Antagonist e.g. (α-blocker) Phenoxybenzamine Dec 31, 2024  Antagonis m 1. Pharmacological Antagonists: (act on same receptor) 2 types Competitive antagonists ( -B) Noncompetitive antagonists (α -B) 2. Chemical Antagonists: away from receptor, e.g –ve charge Heparin neutraliz. by +ve charge Protamine Dec 31, 2024 2. Physiological Antagonists : acting on a  Mechanism of Drug Action Receptor- Non-Receptor- mediated mediated Dec 31, 2024  Receptor- mediated Signaling Mechanisms Dec 31, 2024 - Drugs Acting by Physical Means Demulcents (soothing): bismuth salts coat gastric mucosa PU Adsorbents: charcoal adsorbs gases and toxins in intestine. Lubricants: liquid paraffin is used in Dec 31, 2024. Drugs Acting by Chemical Action Antacids act in peptic ulcer by neutralizing HCl in PU Protamine +ve charges neutralize -ve Dec 31, 2024  Chelation Ability of a drug to form complex with metals → inactivation & easily excreted.  used in TTT of metal poisoning  e.g Desferroamine in Fe toxicity Penicillamine in Cu ……..Wilson disease Dec 31, 2024 Dec 31, 2024