Pharmaceuticals Training Quiz - Tablets and Granules

Ketesse Portfolio

• Dexketoprofen trometamol tablets: 25 mg, pack of 20 tablets
• Dexketoprofen trometamol granules: 25 gm, sachets pack of 20
• Dexketoprofen trometamol injection: 50gm/2ml, solution for injection or infusion, available pack: 5 vials

Market Definition

• Therapeutic area: M01A Antirheumatic Non-Steroid, N02B Non-Narcotic Analgesics
• Market reconstruct: All NSAID molecules excluding paracetamol and paracetamol + caffeine products

Pharmaceutical Forms

• Tablets: solid oral formulations
• Injection: injectable forms, vials, ampoules - all pack sizes
• Sachet: solid oral formulations in sachet or granules only

Product Description - KETESSE Tablet

• Dexketoprofen trometamol 25 mg
• Pack of 20 film-coated tablets
• Indication: symptomatic treatment of pain of mild to moderate intensity (musculo-skeletal pain, dysmenorrhoea, dental pain)

Product Features - KETESSE Tablet

• High potency and efficacy as analgesic providing pain relief
• Fast onset
• High safety and tolerability profile

Posology - KETESSE Tablet

• Recommended dose: 25 mg every 8 hours

• Total daily dose should not exceed 75mg### Non-Narcotics Analgesics and Antirheumatics Market in Iraq

• The market size is valued at 41 million USD with 37 million units sold, having a 1% 5-year CAGR (units) and -1% value CAGR.

• The market is segmented into molecules, including diclofenac, mefenamic acid, etodolac, and others.

• The top molecules in the market are:

  • Diclofenac
  • Mefenamic acid
  • Etodolac
  • Combination of aceclofenac and paracetamol

• There are over 600 brands in the Iraqi market, with the top brands being:

  • MEFRIL
  • OPTIFENAC
  • DIVON-SR
  • FENDOL
  • PONSTAN FORTE

Dexketoprofen in Iraq

• Dexketoprofen is available in 3 brands in the market, with only one consistent brand, Dexday (a Turkish brand composed of dispersible tablets, 50mg).
• The market size is decreasing, with a -21% unit growth rate and -23% value growth rate.
• The top formulation of Dexketoprofen is:
  • Dexketoprofen Trometamol
  • Dexketoprofen + Paracetamol
• The top brands of Dexketoprofen in Iraq are:
  • Berlin Chemie (25mg tablet)
  • Neutec- Turkey (50mg effervescent tablet)
  • Berko Ilac - Turkey (25mg tablet + 500mg paracetamol)

Note: All data is based on the source AMS MAT Q4.### Product Description

• KETESSE Granules: dexketoprofen trometamol 25 mg, granules for oral solution, pack of 20 sachets, for symptomatic treatment of pain of mild to moderate intensity.
• KETESSE Injection: dexketoprofen 50 mg/2ml, pack of 1, 5, and 20 vials, injectable solution, for IV (Bolus+ Infusion) and IM administration.

Pricing

• KETESSE Granules: priced at 9.53 USD, average price of 8.69 USD, pack of 30 launched in Q2 2021 at an average price of 9.37 USD.

Market Analysis

• Defined market: N02B NON NARCOTICS ANALGESICS/M01A1 ANTIRHEUMATICS-NON-S-PLN, granules and sachets only (minus paracetamol).
• Valued at 4M USD, with 0.7M units sold, having a 1% 5-year CAGR (units) and 7% value CAGR.

Competitive Landscape

• Around 26 brands exist in the Iraqi market as either sachet or granules.
• No dexketoprofen products available.
• Diclosan and Lofnac both launched in Q4 2021, having 1% market share in Y1.

Product Features

• KETESSE Granules: lemon flavored, rapidly absorbed, peak concentration 30% higher compared to tablets.
• KETESSE Injection: high potency and efficacy as an analgesic, providing pain relief, flexible administration, compatible with other molecules, and high safety and tolerability profile.

Posology

• KETESSE Granules: recommended dose is 25 mg every 8 hours, total daily dose should not exceed 75 mg.
• KETESSE Injection: recommended dose is 50 mg every 8 – 12 hours, can be repeated 6 hours apart, total daily dose should not exceed 150 mg.