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Questions and Answers
What is a primary disadvantage of using oral powders?
What is a primary disadvantage of using oral powders?
Why might some drugs be administered as powders rather than tablets or capsules?
Why might some drugs be administered as powders rather than tablets or capsules?
Which type of effect can medicated powders for oral use NOT aim for?
Which type of effect can medicated powders for oral use NOT aim for?
What is a benefit of oral powders compared to solid dosage forms for systemic use?
What is a benefit of oral powders compared to solid dosage forms for systemic use?
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How should oral powders generally be administered?
How should oral powders generally be administered?
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What is a potential issue with the stored oral powders?
What is a potential issue with the stored oral powders?
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Why are antibiotics for children often prepared as oral powders rather than liquid dosage forms?
Why are antibiotics for children often prepared as oral powders rather than liquid dosage forms?
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Under what conditions do oral powders remain stable for up to 2 weeks?
Under what conditions do oral powders remain stable for up to 2 weeks?
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What characteristic of nasal powders makes them rapidly absorbed?
What characteristic of nasal powders makes them rapidly absorbed?
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Why are drug delivery devices for nasal powders developed?
Why are drug delivery devices for nasal powders developed?
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What type of diluent is typically used with nasal powders in gelatine capsules?
What type of diluent is typically used with nasal powders in gelatine capsules?
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How is the drug delivered once the capsule is placed in the nasal delivery device?
How is the drug delivered once the capsule is placed in the nasal delivery device?
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What is the primary method of drug administration for nasal powders?
What is the primary method of drug administration for nasal powders?
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What is the purpose of dry powder inhalers (DPIs) in administering aerosol powders?
What is the purpose of dry powder inhalers (DPIs) in administering aerosol powders?
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Which particle size range is typical for the micronized medication in aerosol powders used for lung distribution?
Which particle size range is typical for the micronized medication in aerosol powders used for lung distribution?
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Which of the following are included in aerosol powders besides the therapeutic agent?
Which of the following are included in aerosol powders besides the therapeutic agent?
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What is the main reason for using aerosol powders in the treatment of asthma?
What is the main reason for using aerosol powders in the treatment of asthma?
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Why are pharmaceutical diluents like crystalline alpha-lactose monohydrate used in aerosol powders?
Why are pharmaceutical diluents like crystalline alpha-lactose monohydrate used in aerosol powders?
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Study Notes
Medicated Powders for Oral Use
- Medicated powders for oral use can have local effects (e.g., laxatives) or systemic effects (e.g., analgesics).
- They may be preferred by patients who have difficulty swallowing solid dosage forms.
- Some drugs with bulky doses may be administered as powders, which can be mixed with a liquid or soft food.
Powders taken orally for systemic use
- Powders result in faster rates of dissolution and absorption than solid dosage forms.
- They have immediate contact with the gastric fluids.
- However, therapeutic response may be negligible or only minimal, depending on the drug release characteristics of counterpart products.
Primary Disadvantages of Oral Powders
- Unwanted taste of the drug.
- Antibiotics for children are oral powder or granules that are unstable in liquid form, but remain stable for up to 2 weeks when stored properly.
Characteristics of Oral Powders
- Composed of solid, loose, dry particles of varying degrees of fine particle size.
- Contain one or more active substances with or without excipients and approved colouring matter and flavouring.
- Generally administered with water or another suitable liquid, or swallowed directly.
- All powders and granules should be stored in a dry place to prevent deterioration due to moisture ingress.
Nasal Powder
- Medicated powders intended for inhalation into the nasal cavity using a suitable device.
- Potent drugs are presented this way because they are rapidly absorbed when administered as a fine powder via the nose.
- Delivery devices enhance convenience and ensure a uniform dose is delivered on each actuation.
Aerosol Powders
- Administered by inhalation with the aid of dry powder inhalers (DPIs), which deliver micronized particles of medication in metered quantities.
- Used in the treatment of asthma and other bronchial disorders that require distribution of medication deep in the lungs.
- Particle size of the micronized medication is prepared in the range of 1 to 6 µm in diameter.
Components of Aerosols
- Inert propellants
- Pharmaceutical diluents (e.g., crystalline alpha-lactose monohydrate) to aid flow properties, metering uniformity, and protect the powder from humidity.
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Description
Medicated powders for oral use are intended for local or systemic effects, preferred by patients with difficulty swallowing solid dosage forms, and suitable for bulky drug doses. They can be mixed with a liquid or soft food for administration.
