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Questions and Answers
What is the purpose of including excipients in tablet formulations?
What is the purpose of including excipients in tablet formulations?
- To make tablets dissolve faster
- To ensure the smooth running of the tableting operation (correct)
- To provide flavor to the tablets
- To enhance the color of the tablets
How are excipients usually categorized based on their intended function in tablets?
How are excipients usually categorized based on their intended function in tablets?
- Based on their intended main function (correct)
- Based on their taste
- Based on their color
- Based on their weight
Why are many substances used in tablet formulations described as multi-functional?
Why are many substances used in tablet formulations described as multi-functional?
- Because they have a single purpose in tablet formulations
- Because they can alter the aroma of the tablets
- Because they add extra flavor to the tablets
- Because they can affect the properties of a powder or tablet in multiple ways (correct)
Which of the following is NOT a common function of excipients used in tablets?
Which of the following is NOT a common function of excipients used in tablets?
Why are excipients considered essential in tablet manufacturing?
Why are excipients considered essential in tablet manufacturing?
What is the purpose of disintegrating tablets?
What is the purpose of disintegrating tablets?
Which type of tablet is designed to dissolve in the mouth, not requiring swallowing?
Which type of tablet is designed to dissolve in the mouth, not requiring swallowing?
What distinguishes effervescent tablets from regular tablets?
What distinguishes effervescent tablets from regular tablets?
In which category of tablets can prolonged-release types be found?
In which category of tablets can prolonged-release types be found?
Where can one find definitions of different tablet types according to the text?
Where can one find definitions of different tablet types according to the text?
What is the main difference between sublingual and buccal tablets?
What is the main difference between sublingual and buccal tablets?
What is the main difference between immediate-release and modified-release tablets?
What is the main difference between immediate-release and modified-release tablets?
Which type of tablet is intended to increase the time period for drug absorption after a single administration?
Which type of tablet is intended to increase the time period for drug absorption after a single administration?
What is the characteristic of prolonged-release tablets?
What is the characteristic of prolonged-release tablets?
In what form should modified-release tablets normally be taken?
In what form should modified-release tablets normally be taken?
Which type of tablet is released slowly at a nearly constant rate?
Which type of tablet is released slowly at a nearly constant rate?
What is accomplished by releasing the drug in two or more pulses?
What is accomplished by releasing the drug in two or more pulses?
What is the most common type of delayed-release tablet mentioned in the text?
What is the most common type of delayed-release tablet mentioned in the text?
In which part of the intestine is a gastroresistant tablet designed to release the drug?
In which part of the intestine is a gastroresistant tablet designed to release the drug?
What are the different drug release mechanisms mentioned in the text?
What are the different drug release mechanisms mentioned in the text?
How is drug release managed in a diffusion-controlled release unit?
How is drug release managed in a diffusion-controlled release unit?
What is another term for a gastroresistant tablet?
What is another term for a gastroresistant tablet?
In which part of the intestine can a delayed-release tablet be designed for local treatment?
In which part of the intestine can a delayed-release tablet be designed for local treatment?
In which type of tablet system does the drug partition into the membrane surrounding the dose unit before being released?
In which type of tablet system does the drug partition into the membrane surrounding the dose unit before being released?
What is the primary mechanism of drug release in erosion-controlled release systems?
What is the primary mechanism of drug release in erosion-controlled release systems?
What is the rate-limiting step in dissolution-controlled release systems?
What is the rate-limiting step in dissolution-controlled release systems?
Which of the following describes the drug release mechanism in osmosis-controlled systems?
Which of the following describes the drug release mechanism in osmosis-controlled systems?
What distinguishes diffusion-controlled release reservoir systems from diffusion-controlled release matrix systems?
What distinguishes diffusion-controlled release reservoir systems from diffusion-controlled release matrix systems?
What step precedes the drug being exposed to gastrointestinal fluids in erosion-controlled release systems?
What step precedes the drug being exposed to gastrointestinal fluids in erosion-controlled release systems?
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Study Notes
Tablet Classification
- Tablets can be classified based on the drug release pattern from the tablets
- Four categories of tablets are commonly used: immediate release, prolonged release, pulsatile release, and delayed release
Immediate Release Tablets
- Drug is released rapidly after administration or dissolved in liquid before intake
- Most common type of tablet
- Includes disintegrating, chewable, effervescent, sublingual, and buccal tablets
Modified-Release Tablets
- Should be swallowed intact
- Formulation and excipients used may differ from those of immediate-release tablets
- Includes prolonged release, pulsatile release, and delayed release tablets
Prolonged Release Tablets
- Drug is released slowly at a nearly constant rate
Pulsatile Release Tablets
- Drug is released in two or more pulses to increase the time period for drug absorption
Delayed Release Tablets
- Drug is liberated from the tablet some time after administration
- Examples include gastroresistant (enteric-coated) tablets, which release the drug in the upper part of the small intestine
Tablet Excipients
- Excipients are included in a tablet to ensure the tableting operation can run satisfactorily and to produce tablets of specified quality
- Excipients can affect the properties of a powder or the tablet in multiple ways
- Examples of excipients include substances used for different functions, such as disintegrating agents, lubricants, and binders
Drug Release Mechanism
- Can be divided into four types: diffusion-controlled, dissolution-controlled, erosion-controlled, and osmosis-controlled
- Diffusion-controlled release: drug is released from a matrix or reservoir system through diffusion
- Dissolution-controlled release: drug is released through the dissolution of a coating
- Erosion-controlled release: drug is released through the erosion of a matrix material
- Osmosis-controlled release: drug is released through the movement of water into the tablet through a semipermeable membrane
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