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Pharmaceutical Suspensions Overview

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Questions and Answers

What is the main reason for formulating drugs with very low solubility as suspensions?

To mask the unpleasant taste of the drug

To control the drug's release rate

To make the drug easier to swallow (correct)

To improve the stability of the drug

What is a key disadvantage of suspensions?

They are not aesthetically pleasing

They are difficult to formulate

They have a high rate of sedimentation

They are bulky and difficult for patients to carry (correct)

What is the main factor that contributes to the physical instability of pharmaceutical suspensions?

Sedimentation of the dispersed phase

Particle-particle interactions (correct)

Adsorption of ions onto the particle surface

Ionization of functional groups on the drug

How does the adsorption of ions onto the surface of drug particles in a suspension affect the physical stability?

It establishes an electrical double layer around the particles Signup and view all the answers

What is the purpose of formulating drugs with an unpleasant taste as insoluble derivatives?

To make the drug more palatable as a suspension Signup and view all the answers

What is the characteristic particle size range of colloidal systems in pharmaceutical suspensions?

1 to 100 μm Signup and view all the answers

Which of the following is a main aim of the formulation scientist when dealing with pharmaceutical suspensions?

Optimizing stability of the formulation Signup and view all the answers

What kind of system is a pharmaceutical suspension classified as?

Disperse system Signup and view all the answers

In what form are drug particles in a stable pharmaceutical suspension after agitation?

Homogeneously dispersed Signup and view all the answers

Which of the following is NOT a common route of administration for pharmaceutical suspensions?

Intravenous administration Signup and view all the answers