Pharmaceutical Suspensions Overview

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Questions and Answers

What is the main reason for formulating drugs with very low solubility as suspensions?

  • To mask the unpleasant taste of the drug
  • To control the drug's release rate
  • To make the drug easier to swallow (correct)
  • To improve the stability of the drug

What is a key disadvantage of suspensions?

  • They are not aesthetically pleasing
  • They are difficult to formulate
  • They have a high rate of sedimentation
  • They are bulky and difficult for patients to carry (correct)

What is the main factor that contributes to the physical instability of pharmaceutical suspensions?

  • Sedimentation of the dispersed phase
  • Particle-particle interactions (correct)
  • Adsorption of ions onto the particle surface
  • Ionization of functional groups on the drug

How does the adsorption of ions onto the surface of drug particles in a suspension affect the physical stability?

<p>It establishes an electrical double layer around the particles (A)</p> Signup and view all the answers

What is the purpose of formulating drugs with an unpleasant taste as insoluble derivatives?

<p>To make the drug more palatable as a suspension (B)</p> Signup and view all the answers

What is the characteristic particle size range of colloidal systems in pharmaceutical suspensions?

<p>1 to 100 μm (C)</p> Signup and view all the answers

Which of the following is a main aim of the formulation scientist when dealing with pharmaceutical suspensions?

<p>Optimizing stability of the formulation (C)</p> Signup and view all the answers

What kind of system is a pharmaceutical suspension classified as?

<p>Disperse system (C)</p> Signup and view all the answers

In what form are drug particles in a stable pharmaceutical suspension after agitation?

<p>Homogeneously dispersed (B)</p> Signup and view all the answers

Which of the following is NOT a common route of administration for pharmaceutical suspensions?

<p>Intravenous administration (A)</p> Signup and view all the answers

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