Podcast
Questions and Answers
What type of suspension is prepared for drugs that are not stable in solution?
What type of suspension is prepared for drugs that are not stable in solution?
Which of the following physical properties of a well-formulated suspension involves ease of resuspending sediment?
Which of the following physical properties of a well-formulated suspension involves ease of resuspending sediment?
What is one of the reasons for preparing suspensions?
What is one of the reasons for preparing suspensions?
Which type of suspension requires careful control of particle size to avoid a gritty texture?
Which type of suspension requires careful control of particle size to avoid a gritty texture?
Signup and view all the answers
Which aspect is not a characteristic of a well-formulated suspension?
Which aspect is not a characteristic of a well-formulated suspension?
Signup and view all the answers
What defines a pharmaceutical suspension?
What defines a pharmaceutical suspension?
Signup and view all the answers
Which of the following is NOT a component of a disperse system?
Which of the following is NOT a component of a disperse system?
Signup and view all the answers
What is a characteristic of coarse suspensions?
What is a characteristic of coarse suspensions?
Signup and view all the answers
Which type of dispersion system consists of solid particles less than 1 µm in diameter?
Which type of dispersion system consists of solid particles less than 1 µm in diameter?
Signup and view all the answers
Which of the following purposes does preparation of pharmaceutical suspensions NOT serve?
Which of the following purposes does preparation of pharmaceutical suspensions NOT serve?
Signup and view all the answers
What is a key consideration when selecting the particle size for suspensions?
What is a key consideration when selecting the particle size for suspensions?
Signup and view all the answers
Why is it essential to use the stable polymorphic form of a drug in suspensions?
Why is it essential to use the stable polymorphic form of a drug in suspensions?
Signup and view all the answers
How can temperature fluctuations affect drug suspensions?
How can temperature fluctuations affect drug suspensions?
Signup and view all the answers
What is the ideal particle size range for drug suspensions to avoid issues?
What is the ideal particle size range for drug suspensions to avoid issues?
Signup and view all the answers
What effect does increasing the viscosity of the vehicle in a suspension have?
What effect does increasing the viscosity of the vehicle in a suspension have?
Signup and view all the answers
Which technique could be used to control crystal growth in drug suspensions?
Which technique could be used to control crystal growth in drug suspensions?
Signup and view all the answers
Why is avoiding a metastable form of a drug critical in suspension formulation?
Why is avoiding a metastable form of a drug critical in suspension formulation?
Signup and view all the answers
What is the consequence of not controlling particle size distribution in a suspension?
What is the consequence of not controlling particle size distribution in a suspension?
Signup and view all the answers
What is one of the main advantages of suspensions over solutions in terms of drug stability?
What is one of the main advantages of suspensions over solutions in terms of drug stability?
Signup and view all the answers
How can the formulation of a drug in a suspension help when administering it in the gastrointestinal tract?
How can the formulation of a drug in a suspension help when administering it in the gastrointestinal tract?
Signup and view all the answers
Which of the following is a reason to formulate a drug as a suspension for parenteral administration?
Which of the following is a reason to formulate a drug as a suspension for parenteral administration?
Signup and view all the answers
What role does particle size play in the formulation of suspensions for prolonged drug activity?
What role does particle size play in the formulation of suspensions for prolonged drug activity?
Signup and view all the answers
Which of the following suspensions is typically used to neutralize excess acidity in the stomach?
Which of the following suspensions is typically used to neutralize excess acidity in the stomach?
Signup and view all the answers
Which of the following drugs is mentioned as an example for the use of a suspension for topical application?
Which of the following drugs is mentioned as an example for the use of a suspension for topical application?
Signup and view all the answers
What type of vehicle formulation is typically used in parenteral suspensions to prolong drug activity?
What type of vehicle formulation is typically used in parenteral suspensions to prolong drug activity?
Signup and view all the answers
What is one disadvantage of using a solution over a suspension for administering certain drugs?
What is one disadvantage of using a solution over a suspension for administering certain drugs?
Signup and view all the answers
Study Notes
Pharmaceutical Suspensions
- Pharmaceutical suspensions are liquid dosage forms containing solid particles dispersed in a liquid medium.
- Suspension particles are larger than 1µm (coarse suspensions)
- The liquid is often a solvent or aqueous solution
- The dispersed phase is insoluble in the dispersion medium
Liquid Dosage Forms
- Solutions: one homogeneous phase created by dissolving one or more solutes in a solvent
- Suspensions: a dispersion system where solid particles (≥1µm) are dispersed in a liquid phase
- Colloids: a dispersion system where solid particles (<1µm) are dispersed in a liquid
- Emulsions: a dispersion system consisting of two immiscible liquids (cloudy appearance)
Types of Pharmaceutical Suspensions
- According to Dispersion Medium: Aqueous (water-based) and Oily
- According to Stability: Ready-to-use suspensions (for stable drugs) and Reconstituted suspensions ("powder for reconstitution" for less stable drugs)
- According to Formulation: Flocculated or Deflocculated
- According to Application: Oral, Parenteral, Topical, Ocular
Properties of Well-Formulated Suspensions
- Homogeneity: Remain homogenous between shaking and dose removal
- Sediment Resuspension: Sediment should be easily resuspended with moderate agitation
- Viscosity: Low enough for easy product removal
- Particle Size: Uniform particle size for smooth texture, not gritty
- Microbial Resistance: Resistant to microbial contamination
Reasons for Preparing Suspensions
- Difficulty in Swallowing: For patients with difficulties swallowing solid dosage forms
- Poor Drug Solubility: Drugs with poor solubility
- Unpleasant Taste: For drugs with bad taste which is more prominent in solution form
- Stability: Drugs susceptible to degradation in water
Preformulation of Suspensions
- Particle Size Selection: Suitable particle size and distribution is crucial to prevent issues like gritty texture or irritation
- Particle Size Range: Use a particular particle size to control drug solubility and bioavailability; Narrow size is preferred
- Polymorphic Forms: Use stable polymorphic forms to prevent particle size changes. Metastable forms (soluble) may convert to less soluble forms leading to precipitation and changes in particle size
- Temperature Control: Prevent temperature fluctuations to minimize crystallization and subsequent particle size changes
Other Information
- Aerosol Suspensions: Suspensions of active agent in propellants used for topical inhalation
- Parenteral Suspensions: Suspensions for injection (IM or IV) for prolonged action or better drug stability
- Dosage Forms: Classification of the different types of suspension formats (e.g., Emulsions, Milk, Creams)
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
This quiz covers the essential concepts of pharmaceutical suspensions, a crucial area in liquid dosage forms. You will explore different types of suspensions, their properties, and the differences between suspensions, solutions, colloids, and emulsions. Test your knowledge and comprehension of this important topic in pharmaceutical sciences.
