Pharmaceutical Organic Chemistry-3 Quiz
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Questions and Answers

Which type of substitution reactions do furan, thiophene, and pyrrole undergo?

  • They do not undergo any substitution reactions
  • Only undergo electrophilic substitution at the 𝛽- position
  • Only undergo nucleophilic substitution reactions
  • Undergo both electrophilic and nucleophilic substitution reactions (correct)
  • Which of the following is a basic property of pyrrole?

  • Has strong acidic properties
  • Forms a trimer in concentrated solutions (correct)
  • Undergoes electrophilic substitution at the 𝛽- position
  • Undergoes nucleophilic substitution reactions easily
  • Which statement about the aromatic character of these five-membered heterocycles is correct?

  • They do not exhibit any aromatic character
  • Their aromatic character is due to the presence of 3 p-electrons
  • Their aromatic character is due to the presence of 5 p-electrons
  • Their aromatic character is similar to that of benzene (correct)
  • Which atom in furan and thiophene is sp2 hybridized?

    <p>Oxygen in furan and sulphur in thiophene</p> Signup and view all the answers

    What is the color of the polymeric product known as pyrrole red?

    <p>Dark colored</p> Signup and view all the answers

    Polymeric product known as pyrrole red is formed in __________ solutions

    <p>concentrated</p> Signup and view all the answers

    Pyrrole has a weak __________ property

    <p>acidic</p> Signup and view all the answers

    Furan, thiophene and pyrrole undergo electrophilic substitution at the 𝛼- (2- ) __________

    <p>position</p> Signup and view all the answers

    The oxygen atom in furan and the sulphur atom in thiophene are __________ hybridized

    <p>sp2</p> Signup and view all the answers

    Pyrrole in dilute acids forms a trimer and in concentrated solutions it polymerizes to a dark colored polymeric product known as __________

    <p>pyrrole red</p> Signup and view all the answers

    Study Notes

    Heterocycles: Furan, Thiophene, and Pyrrole

    • Furan, thiophene, and pyrrole undergo electrophilic substitution reactions.
    • Pyrrole has a basic property, which is being weakly basic.

    Aromatic Character

    • The correct statement about the aromatic character of these five-membered heterocycles is that they exhibit aromatic character.

    Hybridization

    • In furan and thiophene, the oxygen and sulfur atoms, respectively, are sp2 hybridized.

    Pyrrole Red

    • Pyrrole red is a dark-colored polymeric product formed in acidic solutions.
    • Pyrrole has a weak acidic property.

    Substitution Reactions

    • Furan, thiophene, and pyrrole undergo electrophilic substitution at the 𝛼- (2-) position.

    Acidic Reactions

    • Pyrrole in dilute acids forms a trimer and in concentrated solutions, it polymerizes to form pyrrole red.

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    Description

    Test your knowledge of pharmaceutical organic chemistry with a focus on heterocyclic chemistry. This quiz covers topics relevant to clinical PharmD students at a level 2 proficiency.

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