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Pharmaceutical Dosage Formulation Development
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Pharmaceutical Dosage Formulation Development

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Questions and Answers

What is the purpose of a preformulation study in pharmaceutical development?

To understand the physical and chemical properties of the drug and its interaction with excipients.

What type of emulsions can be formed using the materials listed, and what determines the type of emulsion formed?

O/W or W/O emulsions; The type of emulsion formed depends on the ratio of oil to water and the HLB value of the emulsifier.

What is the purpose of a gelling agent like polycarbophil in the Emulgel preparation?

To provide a three-dimensional framework for the emulsion, creating a stable and consistent gel structure.

What is the significance of the swelling index evaluation test in the Emulgel preparation?

<p>To evaluate the ability of the gel to absorb and retain water, indicating its moisturizing properties.</p> Signup and view all the answers

What is the purpose of an accelerated stability study in the Emulgel preparation?

<p>To evaluate the product's stability under accelerated storage conditions, predicting its shelf life and stability over time.</p> Signup and view all the answers

What is the primary function of penetration enhancers like Cyclodextrin and Crown Ethers in the Emulgel formulation?

<p>To enhance the permeation of the drug through the biological membranes.</p> Signup and view all the answers

What is the role of emulsifiers like Poloxamer 188 and Span 80 in the Emulgel preparation?

<p>To reduce the interfacial tension between the oil and water phases, stabilizing the emulsion.</p> Signup and view all the answers

What is the purpose of evaluating the physical appearance of the Emulgel formulation?

<p>To assess the visual characteristics of the formulation, such as its color, texture, and consistency.</p> Signup and view all the answers

What is the significance of the globule size and its distribution in the Emulgel formulation?

<p>It affects the stability and release of the drug from the formulation.</p> Signup and view all the answers

What is the purpose of the in vivo release study in the Emulgel evaluation?

<p>To assess the release of the drug from the formulation in a living organism.</p> Signup and view all the answers

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