Pharmaceutical Chemistry Overview
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Questions and Answers

What does a double arrow in a chemical reaction signify?

  • The reaction produces a gas.
  • The reaction occurs at high temperature.
  • The reaction is irreversible.
  • The reaction is reversible. (correct)

    • What happens when an acid drug donates a proton?

  • It maintains its acid form.
  • It increases in solubility.
  • It transforms into its conjugate base form. (correct)
  • It becomes a weak base.

    • What is characteristic of strong acids and bases in solution?

  • They completely dissociate. (correct)
  • They dissociate partially.
  • They reach equilibrium quickly.
  • They form primarily neutral forms.

    • What is likely to happen when a weak acid drug moves across a cellular membrane?

    <p>It will establish an equilibrium between both sides.</p> Signup and view all the answers

    What happens to a base when it accepts a proton?

    <p>It becomes positively charged.</p> Signup and view all the answers

    Which characteristic is true about the majority of drugs?

    <p>They are weak acids and bases.</p> Signup and view all the answers

    What effect does reaching equilibrium have on the movement of drug molecules across membranes?

    <p>It stops the movement of molecules.</p> Signup and view all the answers

    What form does a weak acid take after giving up a proton?

    <p>Conjugate base form.</p> Signup and view all the answers

    What was Zack's initial intention regarding his mustache?

    <p>To maintain it for the new cohort interviews</p> Signup and view all the answers

    How did Tasha Zochert's husband react to growing a mustache?

    <p>He ended up styling it extensively</p> Signup and view all the answers

    What does Zack express about maintaining his mustache?

    <p>He feels it's unnecessary and plans to shave it off soon</p> Signup and view all the answers

    How long has Zack been growing his mustache?

    <p>Since October last year</p> Signup and view all the answers

    What happens to an uncharged acid when it donates a proton?

    <p>It turns into a charged anion.</p> Signup and view all the answers

    What did Zack imply about the care required for facial hair?

    <p>It's complicated and requires extensive knowledge</p> Signup and view all the answers

    What ultimately influences Zack's decision about keeping his mustache?

    <p>His focus on upcoming interviews</p> Signup and view all the answers

    Which statement is true regarding pKa?

    <p>pKa is a measure of acidity in a solution.</p> Signup and view all the answers

    What reaction does Elizabeth Long have when she first sees Zack?

    <p>She is surprised by his mustache</p> Signup and view all the answers

    Which of the following correctly describes the relationship between pKa and acid strength?

    <p>Lower pKa indicates stronger acids.</p> Signup and view all the answers

    What aspect of facial hair maintenance does Tasha highlight?

    <p>It requires a lot of time and dedication</p> Signup and view all the answers

    Why is pKb mentioned in the context of discussing pKa?

    <p>It represents the strength of bases.</p> Signup and view all the answers

    Which equation can be used in conjunction with pKa to analyze pH?

    <p>Henderson-Hasselbalch equation.</p> Signup and view all the answers

    What is the implication of an acid having a low pKa value?

    <p>The acid is strong and readily donates protons.</p> Signup and view all the answers

    What is considered the primary textbook for studying farm?

    <p>Stolting's farm</p> Signup and view all the answers

    What does the term 'proton greediness' relate to in the context of pKa?

    <p>The strength and tendency of an acid to dissociate.</p> Signup and view all the answers

    Why might a student choose to read NagelHow in addition to Stolting's farm?

    <p>It provides different wording that can reinforce learning.</p> Signup and view all the answers

    What is the significance of pKa in drug formulation?

    <p>It helps predict how the drug will behave in biological systems.</p> Signup and view all the answers

    How does Stolting's farm compare to NagelHow in terms of comprehensiveness?

    <p>Stolting's farm covers more subjects deeply than NagelHow.</p> Signup and view all the answers

    What sources did Kelly Elmore use to compile information for the students?

    <p>Other resources in addition to Stolting's and NagelHow.</p> Signup and view all the answers

    What is the purpose of the study guide mentioned by Kelly Elmore?

    <p>To provide additional study tips for students.</p> Signup and view all the answers

    What is a characteristic of NagelHow as stated by Kelly Elmore?

    <p>It is very comprehensive for nurse anesthesia practice.</p> Signup and view all the answers

    Which of the following is true about the C exam and nce in relation to these textbooks?

    <p>Both texts are utilized for preparation.</p> Signup and view all the answers

    What should students be aware of regarding Stolting's farm and NagelHow?

    <p>They might contain mistakes according to Kelly Elmore.</p> Signup and view all the answers

    What factor significantly affects the distribution of a drug in the body?

    <p>Chemical structure of the drug</p> Signup and view all the answers

    What role does protein binding play in drug distribution?

    <p>It traps the drug in circulatory systems</p> Signup and view all the answers

    Which process requires energy and can move drugs against a concentration gradient?

    <p>Active transport</p> Signup and view all the answers

    What is the effect of drug molecular size on its distribution?

    <p>Smaller drugs fit through cellular membranes more easily</p> Signup and view all the answers

    How does capillary permeability influence drug distribution?

    <p>It affects how quickly drugs can enter circulation</p> Signup and view all the answers

    Which protein is most commonly associated with binding drugs in circulation?

    <p>Albumin</p> Signup and view all the answers

    What happens to a drug that is bound to a protein in the body?

    <p>It cannot exert pharmacologic effects</p> Signup and view all the answers

    Which type of drug movement typically follows a concentration gradient?

    <p>Passive diffusion</p> Signup and view all the answers

    What is bioavailability in the context of drug administration?

    <p>The fraction of drug that gets to systemic circulation.</p> Signup and view all the answers

    Why are intravenous (IV) drugs considered to have 100% bioavailability?

    <p>They bypass first-pass metabolism.</p> Signup and view all the answers

    Which factor can reduce the bioavailability of an orally administered drug?

    <p>First-pass hepatic metabolism.</p> Signup and view all the answers

    Which physiological condition creates the strongest gradient for the passage of a weak base anesthetic from mother to fetus?

    <p>Maternal acidosis and fetal alkalosis.</p> Signup and view all the answers

    What happens to the weak base anesthetic once it passes into fetal circulation?

    <p>It accepts protons and becomes charged.</p> Signup and view all the answers

    If a drug is administered orally, which factor most significantly affects how much of the drug remains unchanged when it enters systemic circulation?

    <p>Drug formulation and stability.</p> Signup and view all the answers

    What role does drug solubility play in bioavailability?

    <p>Low solubility leads to reduced bioavailability.</p> Signup and view all the answers

    What is a significant consequence of first-pass metabolism in drug administration?

    <p>It reduces the amount of drug that enters systemic circulation unchanged.</p> Signup and view all the answers

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