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PHAR 401 Parenteral Administration Quiz

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Questions and Answers

What is the main advantage of subcutaneous (SC) administration over intravenous (IV) administration?

Reduced risk of bloodstream infection (correct)

Faster and complete absorption

Lower healthcare costs

Less pharmaceutical preparation required

Why does subcutaneous (SC) administration allow smaller dose size?

Reduced risk of necrosis

Complete absorption into the bloodstream

Avoidance of first pass metabolism (correct)

Faster injection process

What is a significant disadvantage of subcutaneous (SC) administration?

Risk of local tissue reactions/hypersensitivity (correct)

Higher patient compliance

Need for a hospital setting

Rapid and complete absorption

Why is subcutaneous (SC) administration considered more convenient for patients and medical staff?

Requires less pharmaceutical preparation Signup and view all the answers

How does subcutaneous (SC) administration contribute to reducing costs for the healthcare system?

Requires less pharmaceutical preparation Signup and view all the answers

What is the driving force for interstitial flow in the absorption pathway of the subcutaneous route?

Osmotic differences among blood, interstitium, and lymphatics Signup and view all the answers

In convective transport in the absorption pathway for small peptides and proteins administered subcutaneously, what is NOT a limiting factor for molecular size?

Diffusion through the ECM Signup and view all the answers

Why is subcutaneous administration frequently considered more immunogenic than intravenous administration?

Presence of dendritic and langerhans cells in the hypodermis Signup and view all the answers

What is a potential limitation of subcutaneous route for peptide/protein therapeutics related to bioavailability?

Variable thickness of the hypodermis in humans Signup and view all the answers

Why may the immunogenicity of biologics after subcutaneous administration decrease compared with intradermal administration?

Presence of antigen-presenting cells mainly in the hypodermis Signup and view all the answers