PHAR 401 Parenteral Administration Quiz

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Questions and Answers

What is the main advantage of subcutaneous (SC) administration over intravenous (IV) administration?

  • Reduced risk of bloodstream infection (correct)
  • Faster and complete absorption
  • Lower healthcare costs
  • Less pharmaceutical preparation required

Why does subcutaneous (SC) administration allow smaller dose size?

  • Reduced risk of necrosis
  • Complete absorption into the bloodstream
  • Avoidance of first pass metabolism (correct)
  • Faster injection process

What is a significant disadvantage of subcutaneous (SC) administration?

  • Risk of local tissue reactions/hypersensitivity (correct)
  • Higher patient compliance
  • Need for a hospital setting
  • Rapid and complete absorption

Why is subcutaneous (SC) administration considered more convenient for patients and medical staff?

<p>Requires less pharmaceutical preparation (C)</p> Signup and view all the answers

How does subcutaneous (SC) administration contribute to reducing costs for the healthcare system?

<p>Requires less pharmaceutical preparation (C)</p> Signup and view all the answers

What is the driving force for interstitial flow in the absorption pathway of the subcutaneous route?

<p>Osmotic differences among blood, interstitium, and lymphatics (C)</p> Signup and view all the answers

In convective transport in the absorption pathway for small peptides and proteins administered subcutaneously, what is NOT a limiting factor for molecular size?

<p>Diffusion through the ECM (D)</p> Signup and view all the answers

Why is subcutaneous administration frequently considered more immunogenic than intravenous administration?

<p>Presence of dendritic and langerhans cells in the hypodermis (B)</p> Signup and view all the answers

What is a potential limitation of subcutaneous route for peptide/protein therapeutics related to bioavailability?

<p>Variable thickness of the hypodermis in humans (D)</p> Signup and view all the answers

Why may the immunogenicity of biologics after subcutaneous administration decrease compared with intradermal administration?

<p>Presence of antigen-presenting cells mainly in the hypodermis (A)</p> Signup and view all the answers

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