10 Questions
What is the main advantage of subcutaneous (SC) administration over intravenous (IV) administration?
Reduced risk of bloodstream infection
Why does subcutaneous (SC) administration allow smaller dose size?
Avoidance of first pass metabolism
What is a significant disadvantage of subcutaneous (SC) administration?
Risk of local tissue reactions/hypersensitivity
Why is subcutaneous (SC) administration considered more convenient for patients and medical staff?
Requires less pharmaceutical preparation
How does subcutaneous (SC) administration contribute to reducing costs for the healthcare system?
Requires less pharmaceutical preparation
What is the driving force for interstitial flow in the absorption pathway of the subcutaneous route?
Osmotic differences among blood, interstitium, and lymphatics
In convective transport in the absorption pathway for small peptides and proteins administered subcutaneously, what is NOT a limiting factor for molecular size?
Diffusion through the ECM
Why is subcutaneous administration frequently considered more immunogenic than intravenous administration?
Presence of dendritic and langerhans cells in the hypodermis
What is a potential limitation of subcutaneous route for peptide/protein therapeutics related to bioavailability?
Variable thickness of the hypodermis in humans
Why may the immunogenicity of biologics after subcutaneous administration decrease compared with intradermal administration?
Presence of antigen-presenting cells mainly in the hypodermis
Test your knowledge of parenteral administration, including the route of delivery for proteins, advantages, disadvantages, and patient compliance. This quiz covers SC administration of Herceptin and rituximab, as well as general features of parenteral administration.
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