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PHAR 141G Pharmaceutics: Drug Dosage Form and Delivery System Design (I)

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29 Questions

What is the primary characteristic of gas molecules?

Rapid motion and random movement

What is the general gas equation for an ideal gas?

$P = nRT/V$

What is the molar gas constant (R) in the ideal gas law equation?

0.082 L·atm/mol·deg

What is the main pharmaceutical application of compressed gases?

Oxygen, nitrogen, and carbon dioxide

What is the primary driver for the hydrophobic interaction?

Hydrophobic effect

What is the primary role of hydrophobic interactions in biomolecules?

Forming the tertiary structure of proteins

Why are dosage forms needed?

To provide a mechanism for the safe and convenient delivery of accurate dosage

What does preformulation involve?

Determining and defining physical and chemical properties important for formulation

Why is understanding basic chemistry important in drug design?

It contributes to the physicochemical properties and uses of the drug

Which of the following is NOT a parameter involved in a drug's physiological availability and stability?

Drug over-the-counter availability

What is the purpose of studying preformulation studies?

To optimize a drug for stable, effective, and safe dosage form

How does distinguishing between gaseous, liquid, and solid states of matter relate to drug design?

It is crucial in selecting the appropriate state for drug formulation

What determines the size and molecular weight of polymers?

Number of repeating units

Which type of polymers include rubber, polypeptides, and cellulose?

Natural polymers

What is the role of Carbomer in formulations?

Thickening agent

What does HPMC polymer commonly serve as in pharmaceutical applications?

Tablet coating

In what state of matter do gaseous substances exert pressure and occupy volume?

Gas

Which of the following forces are responsible for separating molecules?

Repulsive forces

When repulsive forces and attractive forces are equal, what state does the system achieve?

Equilibrium and minimum potential energy

Which of the following intermolecular interactions is involved in the formation of iodine solutions containing the iodide complex (I2 + K+I- = K+I3-)?

Ion-dipole and ion-induced dipole interactions

Which of the following intermolecular interactions is the strongest?

Ionic bonds

Which of the following intermolecular interactions is involved in the solubility of some drugs?

Van der Waals forces

Which of the following surfactants is mentioned in the given text?

Sodium lauryl sulfate

What type of bond is present in metallic solids?

Metallic bond

Which of the following is a characteristic of crystalline solids?

Regularly repeating pattern with fixed molecular orders

What is the term used for a crystalline solid that has solvent molecules trapped within its crystal structure?

Solvate

Which of the following factors can influence the formation of different polymorphs of a crystalline solid?

All of the above

Which of the following properties can differ between polymorphs of a crystalline solid?

All of the above

Which of the following is an example of a crystalline solid that exhibits polymorphism?

All of the above

This quiz covers the basics of drug dosage forms and drug delivery system design in pharmaceutical sciences. Topics include the need for dosage forms, understanding basic chemistry of molecules, bonds, and their contribution to drug properties.

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