Phagocytosis Quiz

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Questions and Answers

Which of the following is the primary process by which neutrophils and macrophages destroy ingested microbes?

  • Pinocytosis
  • Phagocytosis (correct)
  • Endocytosis
  • Exocytosis

Which of the following are the principal phagocytic receptors on phagocytes?

  • Mannose receptors and other lectins
  • Receptors for antibodies and complement
  • Both A and B (correct)
  • None of the above

What is the process by which phagocyte oxidase converts molecular oxygen into superoxide anion and free radicals?

  • Phagolysosomal fusion
  • Respiratory burst (correct)
  • Oxidative burst
  • Phagocytosis

Which enzyme is responsible for converting arginine to nitric oxide in macrophages?

<p>Inducible nitric oxide synthase (iNOS) (D)</p> Signup and view all the answers

What is the cause of chronic granulomatous disease (CGD)?

<p>Inherited deficiency of phagocyte oxidase enzyme (A)</p> Signup and view all the answers

What is the purpose of neutrophil extracellular traps (NETs)?

<p>To trap and kill bacteria and fungi (A)</p> Signup and view all the answers

What is the reason why inflammation may cause tissue injury?

<p>The injury caused by enzymes and ROS liberated into the extracellular space (B)</p> Signup and view all the answers

What is the size range of particles that can be ingested through phagocytosis?

<p>Between 0.5 μm and 1 μm in diameter (B)</p> Signup and view all the answers

What are the two types of receptors that can bind to microbes during phagocytosis?

<p>Antibody receptors and complement receptors (B)</p> Signup and view all the answers

What is the purpose of the oxidative burst during phagocytosis?

<p>To convert molecular oxygen into superoxide anion and free radicals (B)</p> Signup and view all the answers

What is the main function of lysosomal proteases in phagocytes?

<p>Break down microbial proteins (C)</p> Signup and view all the answers

What happens to neutrophils in response to pathogens and inflammatory mediators?

<p>They die and extrude their nuclear contents to form NETs (A)</p> Signup and view all the answers

What is the cause of chronic granulomatous disease (CGD)?

<p>Inherited deficiency of the phagocyte oxidase enzyme (A)</p> Signup and view all the answers

What is the potential downside of releasing enzymes and ROS into the extracellular space to kill microbes?

<p>They may injure host tissues (D)</p> Signup and view all the answers

Flashcards

Phagocytosis

Neutrophils and macrophages engulf and destroy microbes through this process.

Phagocytic receptors

These receptors on phagocytes are key for recognizing and binding to microbes.

Respiratory burst

Phagocyte oxidase converts oxygen into superoxide and free radicals.

Inducible nitric oxide synthase (iNOS)

This enzyme converts arginine to nitric oxide in macrophages, aiding in microbial killing.

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Chronic granulomatous disease (CGD)

An inherited condition caused by a deficiency in the phagocyte oxidase enzyme.

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Neutrophil extracellular traps (NETs)

Extracellular traps used to trap and kill bacteria and fungi.

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Inflammation tissue injury

Enzymes and ROS released during inflammation can damage surrounding tissues.

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Phagocytosis particle size

This is the optimal size range for particles to be ingested through phagocytosis.

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Microbe-binding receptors

These two receptors can bind to microbes during phagocytosis, marking them for ingestion.

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Oxidative burst

Molecular oxygen converts into superoxide anion and free radicals via this process.

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Lysosomal proteases

Enzymes that break down microbial proteins within phagocytes.

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Neutrophil response to pathogens

Neutrophils respond to pathogens and inflammatory mediators by dying and releasing their nuclear contents.

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Cause of chronic granulomatous disease (CGD)

Inherited deficiency impairs phagocyte oxidase enzyme leading to ineffective microbial killing.

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Extracellular enzyme/ROS downside

These substances released to kill microbes can also harm host tissues.

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