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Pernicious Anemia and Vitamin B12 Deficiency Quiz

Test your knowledge on pernicious anemia and vitamin B12 deficiency symptoms, diagnosis, and treatment. Topics covered include numbness, tingling, poor muscle coordination, and vitamin B12 levels. Learn about serum B12, holotranscobalamin I, intrinsic factor antibody, and parietal cell antibodies.

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@PropitiousBixbite
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Questions and Answers

What is the normal range for Mean Cell Hemoglobin Concentration (MCHC) in adults?

32-36 g/dL

Which type of anemia is associated with low Mean Cell Hemoglobin Concentration (MCHC)?

Iron-deficiency anemia

What are the symptoms of anemia related to inadequate muscle function?

Decreased exercise tolerance

What is a characteristic symptom of anemia related to neurologic behavioral changes?

<p>Anorexia</p> Signup and view all the answers

Which nutrient deficiency is indicated by the presence of spoon-shaped nails (koilonychia)?

<p>Iron deficiency</p> Signup and view all the answers

When is oral iron supplements best absorbed according to the text?

<p>When the stomach is empty</p> Signup and view all the answers

What are some symptoms of pernicious anemia?

<p>Numbness &amp; tingling in hands &amp; feet</p> Signup and view all the answers

How is vitamin B12 deficiency diagnosed?

<p>Serum holotranscobalamin I (holo TCH) &lt; 40 pg/mL</p> Signup and view all the answers

What is the treatment for pernicious anemia?

<p>Intramuscular injections of vitamin B12 once a month</p> Signup and view all the answers

In pernicious anemia, where can vitamin B12 be stored in the body?

<p>Liver</p> Signup and view all the answers

When does anemia of chronic disease typically occur?

<p>With inflammation, infection or malignancy</p> Signup and view all the answers

What is the main process through which iron deficiency evolves in the body?

<p>Cell division</p> Signup and view all the answers

How do reticulocytes become mature red blood cells according to the text?

<p>They cross from bone marrow to blood</p> Signup and view all the answers

Which parameter has a negative feedback effect to control cell division in the context of iron deficiency?

<p>Hemoglobin concentration</p> Signup and view all the answers

What is a characteristic symptom of Fe deficiency anemia mentioned in the text?

<p>Low Hemoglobin levels</p> Signup and view all the answers

Which parameter is used to describe red blood cells in terms of individual cell size?

<p>Mean Corpuscular Volume (MCV)</p> Signup and view all the answers

What parameter can help in diagnosing iron deficiency and anemia according to the text?

<p>Ferritin, iron, and transferrin evaluations</p> Signup and view all the answers

Which mineral deficiency may occur with Zinc supplementation due to competition for binding sites on proteins?

<p>Copper</p> Signup and view all the answers

What type of anemia occurs at the initiation and early stages of a vigorous training program?

<p>Sports anemia</p> Signup and view all the answers

In laboratory data, what does a Serum B12 level of < 150 pg/ml indicate?

<p>B12 deficiency</p> Signup and view all the answers

What is the normal range for Hemoglobin in females?

<p>&gt; 12 g/dl</p> Signup and view all the answers

Which mineral increases the oxygen affinity of Red Blood Cells (RBCs)?

<p>Zinc</p> Signup and view all the answers

What does a Serum Folate level of < 3 ng/ml indicate according to laboratory data?

<p>Deficiency</p> Signup and view all the answers

What is the effect of inflammatory cytokines on iron absorption and erythroblast activity?

<p>Decrease iron absorption and erythroblast activity</p> Signup and view all the answers

What characterizes sickle cell disease in terms of hemoglobin genes inheritance?

<p>Two abnormal hemoglobin genes, one from each parent</p> Signup and view all the answers

What is a common symptom of sickle cell disease due to sickle-shaped RBCs getting caught in capillaries?

<p>Episodes of severe acute abdominal pain</p> Signup and view all the answers

Why is it important to differentiate sickle cell anemia from iron deficiency anemia?

<p>To avoid excessive iron supplementation</p> Signup and view all the answers

What is required for children and families affected by sickle cell anemia in terms of dietary intake during exacerbations?

<p>Higher calorie intake</p> Signup and view all the answers

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