Pernicious Anemia and Vitamin B12 Deficiency Quiz
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Questions and Answers

What is the normal range for Mean Cell Hemoglobin Concentration (MCHC) in adults?

  • 40-45 g/dL
  • 32-36 g/dL (correct)
  • 24-28 g/dL
  • 10-15 g/dL

Which type of anemia is associated with low Mean Cell Hemoglobin Concentration (MCHC)?

  • Iron-deficiency anemia (correct)
  • Sickle cell anemia
  • Megaloblastic anemia
  • Hemolytic anemia

What are the symptoms of anemia related to inadequate muscle function?

  • Abnormal cognitive development
  • Rapid heartbeat
  • Increased appetite
  • Decreased exercise tolerance (correct)

What is a characteristic symptom of anemia related to neurologic behavioral changes?

<p>Anorexia (A)</p> Signup and view all the answers

Which nutrient deficiency is indicated by the presence of spoon-shaped nails (koilonychia)?

<p>Iron deficiency (C)</p> Signup and view all the answers

When is oral iron supplements best absorbed according to the text?

<p>When the stomach is empty (A)</p> Signup and view all the answers

What are some symptoms of pernicious anemia?

<p>Numbness &amp; tingling in hands &amp; feet (D)</p> Signup and view all the answers

How is vitamin B12 deficiency diagnosed?

<p>Serum holotranscobalamin I (holo TCH) &lt; 40 pg/mL (A)</p> Signup and view all the answers

What is the treatment for pernicious anemia?

<p>Intramuscular injections of vitamin B12 once a month (C)</p> Signup and view all the answers

In pernicious anemia, where can vitamin B12 be stored in the body?

<p>Liver (A)</p> Signup and view all the answers

When does anemia of chronic disease typically occur?

<p>With inflammation, infection or malignancy (B)</p> Signup and view all the answers

What is the main process through which iron deficiency evolves in the body?

<p>Cell division (C)</p> Signup and view all the answers

How do reticulocytes become mature red blood cells according to the text?

<p>They cross from bone marrow to blood (C)</p> Signup and view all the answers

Which parameter has a negative feedback effect to control cell division in the context of iron deficiency?

<p>Hemoglobin concentration (C)</p> Signup and view all the answers

What is a characteristic symptom of Fe deficiency anemia mentioned in the text?

<p>Low Hemoglobin levels (D)</p> Signup and view all the answers

Which parameter is used to describe red blood cells in terms of individual cell size?

<p>Mean Corpuscular Volume (MCV) (C)</p> Signup and view all the answers

What parameter can help in diagnosing iron deficiency and anemia according to the text?

<p>Ferritin, iron, and transferrin evaluations (C)</p> Signup and view all the answers

Which mineral deficiency may occur with Zinc supplementation due to competition for binding sites on proteins?

<p>Copper (C)</p> Signup and view all the answers

What type of anemia occurs at the initiation and early stages of a vigorous training program?

<p>Sports anemia (B)</p> Signup and view all the answers

In laboratory data, what does a Serum B12 level of < 150 pg/ml indicate?

<p>B12 deficiency (D)</p> Signup and view all the answers

What is the normal range for Hemoglobin in females?

<p>&gt; 12 g/dl (D)</p> Signup and view all the answers

Which mineral increases the oxygen affinity of Red Blood Cells (RBCs)?

<p>Zinc (A)</p> Signup and view all the answers

What does a Serum Folate level of < 3 ng/ml indicate according to laboratory data?

<p>Deficiency (D)</p> Signup and view all the answers

What is the effect of inflammatory cytokines on iron absorption and erythroblast activity?

<p>Decrease iron absorption and erythroblast activity (A)</p> Signup and view all the answers

What characterizes sickle cell disease in terms of hemoglobin genes inheritance?

<p>Two abnormal hemoglobin genes, one from each parent (D)</p> Signup and view all the answers

What is a common symptom of sickle cell disease due to sickle-shaped RBCs getting caught in capillaries?

<p>Episodes of severe acute abdominal pain (B)</p> Signup and view all the answers

Why is it important to differentiate sickle cell anemia from iron deficiency anemia?

<p>To avoid excessive iron supplementation (D)</p> Signup and view all the answers

What is required for children and families affected by sickle cell anemia in terms of dietary intake during exacerbations?

<p>Higher calorie intake (D)</p> Signup and view all the answers

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