Penicillin G Acid Sensitivity Quiz
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Questions and Answers

Which enzyme is responsible for the final cross-linking reaction in the cell wall biosynthesis process described in the text?

  • Transpeptidase enzyme (correct)
  • Carboxypeptidase enzyme
  • Penicillinase enzyme
  • Peptidoglycanase enzyme
  • What is the function of penicillins and cephalosporins in the context of cell wall biosynthesis?

  • They enhance the permeability of the cell membrane.
  • They inhibit cell wall formation entirely.
  • They inhibit the final cross-linking reaction by the transpeptidase enzyme. (correct)
  • They promote the synthesis of N-acetylmuramic acid (NAM).
  • What structural feature makes penicillins and cephalosporins highly reactive and effective in inhibiting cell wall biosynthesis?

  • Having a high molecular weight
  • Containing a phosphorous group
  • Presence of a β-lactam ring (correct)
  • Incorporation of a thiazolidine ring
  • Which part of penicillins and cephalosporins is primarily responsible for influencing their antibacterial spectrum?

    <p>The side chain attached to the acyl group</p> Signup and view all the answers

    What is the role of the salt concentration imbalance between the cell interior and exterior in the process described?

    <p>Causes water to enter the cell due to osmotic pressure</p> Signup and view all the answers

    Which type of sugar is involved in binding peptide chains in the cell wall structure described in the text?

    <p>N-acetylmuramic acid (NAM)</p> Signup and view all the answers

    What is one of the reasons for the acid sensitivity of penicillin G?

    <p>Ring strain</p> Signup and view all the answers

    Why does the highly reactive β-lactam carbonyl group contribute to the acid sensitivity of penicillin G?

    <p>It reacts readily with nucleophiles</p> Signup and view all the answers

    How does the influence of the acyl chain impact the acid sensitivity of penicillin G?

    <p>It decreases acid stability</p> Signup and view all the answers

    Which modification makes penicillin V more suitable for oral administration compared to penicillin G?

    <p>Introduction of an electronegative oxygen</p> Signup and view all the answers

    What is a characteristic feature of ampicillin and oxacillin in relation to acid sensitivity?

    <p>They are more resistant to penicillinases compared to penicillin G</p> Signup and view all the answers

    How does penicillin V compare to penicillin G in terms of allergic sensitivity?

    <p>Penicillin V is less prone to allergic reactions</p> Signup and view all the answers

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