Pathophysiology of Type 2 Diabetes
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Questions and Answers

What is the main characteristic of type 2 diabetes?

  • Decreased hepatic glucose production
  • Peripheral insulin resistance and inadequate insulin secretion (correct)
  • Reduced breakdown of fat
  • Excessive glucose transport into muscle cells
  • What contributes to the insulin resistance in type 2 diabetes?

  • Low levels of free fatty acids and proinflammatory cytokines in plasma
  • High levels of insulin in plasma
  • Elevated levels of free fatty acids and proinflammatory cytokines in plasma (correct)
  • Low levels of insulin in plasma
  • What is the role of excess glucagon in type 2 diabetes?

  • Regulates glucose transport into muscle cells
  • Increases insulin secretion
  • Reduces glucagon levels in the body
  • Contributes to hyperglucagonemia and hyperglycemia (correct)
  • What was found to be at least 4-fold higher in normoglycemic individuals with high fasting plasma concentrations prior to the onset of diabetes?

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    Study Notes

    Type 2 Diabetes Characteristics

    • Insulin resistance is the main characteristic of type 2 diabetes.

    Insulin Resistance Contributors

    • Insulin resistance in type 2 diabetes is contributed to by a combination of factors, including genetic, environmental, and lifestyle factors.

    Excess Glucagon Role

    • Excess glucagon in type 2 diabetes further contributes to hyperglycemia by stimulating glucose production in the liver.

    Risk Factors

    • High levels of 1-h postload plasma glucose were found to be at least 4-fold higher in normoglycemic individuals with high fasting plasma concentrations prior to the onset of diabetes.

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    Description

    Test your knowledge of the pathophysiology of type 2 diabetes with this quiz. Explore the key factors such as insulin resistance, inadequate insulin secretion, elevated free fatty acids, proinflammatory cytokines, and glucagon imbalance.

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