Pathophysiology of Type 2 Diabetes

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BraveSweetPea
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What are the characteristics of type 2 diabetes?

Peripheral insulin resistance and inadequate insulin secretion

What is the role of excess glucagon in type 2 diabetes?

It leads to hyperglucagonemia and consequent hyperglycemia

What is the effect of high fasting plasma concentrations of 3 amino acids on the risk of future diabetes?

At least 4-fold higher risk of future diabetes

What has been attributed to the insulin resistance in type 2 diabetes?

Elevated levels of free fatty acids and proinflammatory cytokines in plasma

Test your understanding of the pathophysiology of type 2 diabetes characterized by peripheral insulin resistance and inadequate insulin secretion, as well as the role of free fatty acids, proinflammatory cytokines, hepatic glucose production, and glucagon in the development of the condition.

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