Pathophysiology of Infections and Tissue Necrosis
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Questions and Answers

What are the most common and medically important causes of inflammation?

  • Foreign bodies and autoimmune diseases
  • Infections and microbial toxins (correct)
  • Environmental chemicals and physical injury
  • Tissue necrosis and immune reactions

What is the outcome of the interaction between the type of pathogen and the host response?

  • Is always fatal
  • Determines the type of inflammatory response (correct)
  • Always results in autoimmune disease
  • Always results in chronic inflammation

What can cause tissue necrosis?

  • Only bacterial infections
  • Only viral infections
  • Only microbial toxins
  • Ischemia, trauma, and physical and chemical injury (correct)

What can trigger inflammation?

<p>Molecules released from necrotic cells (A)</p> Signup and view all the answers

What are autoimmune diseases often associated with?

<p>Chronic inflammation (A)</p> Signup and view all the answers

What induces autoimmune and allergic reactions?

<p>Cytokines produced by T lymphocytes and other cells (A)</p> Signup and view all the answers

What is a characteristic of acute inflammation?

<p>Exudation of fluid and plasma proteins, emigration of leukocytes (D)</p> Signup and view all the answers

What is the primary cause of tissue damage in autoimmune diseases?

<p>Misdirected inflammatory reaction against self tissues (D)</p> Signup and view all the answers

What is a common feature of chronic inflammation?

<p>Tissue destruction and scarring (B)</p> Signup and view all the answers

What is the term for a systemic inflammatory reaction that causes widespread pathologic abnormalities?

<p>Sepsis (B)</p> Signup and view all the answers

What is the primary difference between acute and chronic inflammation?

<p>Duration of the reaction (A)</p> Signup and view all the answers

What is a common result of chronic inflammation?

<p>Fibrosis and scarring (A)</p> Signup and view all the answers

What is the term for inflammation that arises in response to self antigens?

<p>Autoimmune disease (C)</p> Signup and view all the answers

What is a common underlying mechanism of chronic diseases such as rheumatoid arthritis and atherosclerosis?

<p>Inflammation (B)</p> Signup and view all the answers

What is the function of macrophage scavenger receptors?

<p>To recognize and bind to modified LDL particles and microbes (B)</p> Signup and view all the answers

What is the primary function of opsonins in phagocytosis?

<p>To enhance the efficiency of phagocytosis (C)</p> Signup and view all the answers

What is the result of the fusion of a phagosome with a lysosomal granule?

<p>The formation of a phagolysosome (D)</p> Signup and view all the answers

What is the function of myeloperoxidase (MPO) in neutrophils?

<p>To convert hydrogen peroxide to hypochlorite (C)</p> Signup and view all the answers

What is the function of inducible nitric oxide synthase (iNOS) in macrophages?

<p>To generate peroxynitrite, a highly reactive free radical (D)</p> Signup and view all the answers

What is the function of lysozyme in neutrophils and macrophages?

<p>To break down bacterial cell walls (A)</p> Signup and view all the answers

What is the function of neutrophil extracellular traps (NETs)?

<p>To trap and concentrate antimicrobial substances at sites of infection (B)</p> Signup and view all the answers

What is a consequence of excessive or inappropriate leukocyte activation?

<p>Tissue injury and pathology (D)</p> Signup and view all the answers

What do activated leukocytes produce in addition to antimicrobial factors?

<p>All of the above (D)</p> Signup and view all the answers

What is a possible outcome of the acute inflammatory response?

<p>Tissue injury and pathology (C)</p> Signup and view all the answers

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