Pathophysiology of Coagulation Disorders and Medications
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Questions and Answers

What is the normal range for INR in individuals not taking anticoagulation drugs?

  • 1.5-2.5
  • 2.0-3.0
  • 0.9-1.9
  • 1.1 or below (correct)

    • What is the primary mechanism of action of warfarin?

  • Inhibiting the action of vitamin K (correct)
  • Inhibiting the synthesis of platelets
  • Activating the intrinsic pathway
  • Enhancing the action of thrombin

    • What is the therapeutic class of warfarin?

  • Hemostatic
  • Thrombolytic
  • Antiplatelet
  • Anticoagulant (correct)

    • What is the normal range for platelet counts in healthy individuals?

    <p>150,000-450,000</p> Signup and view all the answers

    What is the primary nursing consideration for patients taking warfarin?

    <p>Monitoring for bleeding</p> Signup and view all the answers

    What is the pharmacologic class of warfarin?

    <p>Vitamin K antagonist</p> Signup and view all the answers

    What is the primary adverse effect of warfarin?

    <p>Bleeding</p> Signup and view all the answers

    What is the pregnancy category of warfarin?

    <p>X</p> Signup and view all the answers

    What is the purpose of overlapping heparin therapy with warfarin?

    <p>To ensure therapeutic anticoagulation</p> Signup and view all the answers

    What is the primary mechanism of action of direct thrombin inhibitors?

    <p>Directly inhibiting thrombin</p> Signup and view all the answers

    What is the main concern when administering anticoagulants to patients with liver impairment?

    <p>Elevated liver enzymes and bilirubin</p> Signup and view all the answers

    What is the primary indication for the use of heparin?

    <p>Preventing excessive clotting within blood vessels</p> Signup and view all the answers

    Why is protamine sulfate used in the treatment of overdose?

    <p>To neutralize heparin effects</p> Signup and view all the answers

    What is the primary side effect of anticoagulants?

    <p>Bleeding</p> Signup and view all the answers

    Why is it essential to monitor the patient's activated partial thromboplastin time (aPTT) when administering heparin?

    <p>To keep the value at 1.5 to 2 times the baseline</p> Signup and view all the answers

    What is the contraindication for dabigatran?

    <p>Active bleeding</p> Signup and view all the answers

    Why is it essential to wait at least 18 hours following the last dose of rivaroxaban to remove an epidural catheter?

    <p>To allow for the elimination of the drug from the system</p> Signup and view all the answers

    What is the primary interaction between heparin and other medications?

    <p>Increased risk of bleeding</p> Signup and view all the answers

    What is the purpose of monitoring the patient's CBC and liver function tests when administering rivaroxaban?

    <p>To monitor liver function and detect potential adverse effects</p> Signup and view all the answers

    Which of the following anticoagulants acts by directly inhibiting thrombin?

    <p>Dabigatran</p> Signup and view all the answers

    What is the primary mechanism of action of heparin?

    <p>Inactivate several clotting factors</p> Signup and view all the answers

    Which of the following is a major adverse effect of heparin administration during spinal or epidural anesthesia?

    <p>Neurologic damage from hematoma</p> Signup and view all the answers

    What is the primary interaction between dabigatran and other medications?

    <p>Increased risk of bleeding with other anticoagulants</p> Signup and view all the answers

    What is the therapeutic class of rivaroxaban?

    <p>Anticoagulant</p> Signup and view all the answers

    What is the primary nursing consideration for patients taking heparin?

    <p>Observe for bleeding</p> Signup and view all the answers

    What laboratory value should be monitored when administering heparin?

    <p>Activated partial thromboplastin time (aPTT)</p> Signup and view all the answers

    What is the treatment of overdose for dabigatran?

    <p>No antidote available</p> Signup and view all the answers

    What is the primary adverse effect of rivaroxaban?

    <p>Bleeding</p> Signup and view all the answers

    What is the contraindication for heparin administration?

    <p>Active internal bleeding</p> Signup and view all the answers

    What is the primary action of warfarin on the synthesis of clotting factors?

    <p>Inhibits the synthesis of clotting factors II, VII, IX, and X</p> Signup and view all the answers

    Which of the following is a contraindication for warfarin therapy?

    <p>Recent trauma</p> Signup and view all the answers

    What is the purpose of monitoring PT levels in patients on warfarin therapy?

    <p>To monitor the effectiveness of warfarin therapy</p> Signup and view all the answers

    Which of the following herbal medications may interact with warfarin?

    <p>Ginkgo</p> Signup and view all the answers

    What is the normal range for aPTT in individuals not receiving heparin therapy?

    <p>30-40 seconds</p> Signup and view all the answers

    What is the primary mechanism of action of warfarin?

    <p>Inhibiting the action of vitamin K</p> Signup and view all the answers

    Which of the following laboratory values is used to monitor the effectiveness of warfarin therapy?

    <p>INR</p> Signup and view all the answers

    What is the pregnancy category of warfarin?

    <p>X</p> Signup and view all the answers

    Which of the following is an adverse effect of warfarin therapy?

    <p>Hepatitis</p> Signup and view all the answers

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