Pathophysiology of Coagulation Disorders and Medications

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Questions and Answers

What is the normal range for INR in individuals not taking anticoagulation drugs?

  • 1.5-2.5
  • 2.0-3.0
  • 0.9-1.9
  • 1.1 or below (correct)

What is the primary mechanism of action of warfarin?

  • Inhibiting the action of vitamin K (correct)
  • Inhibiting the synthesis of platelets
  • Activating the intrinsic pathway
  • Enhancing the action of thrombin

What is the therapeutic class of warfarin?

  • Hemostatic
  • Thrombolytic
  • Antiplatelet
  • Anticoagulant (correct)

What is the normal range for platelet counts in healthy individuals?

<p>150,000-450,000 (C)</p> Signup and view all the answers

What is the primary nursing consideration for patients taking warfarin?

<p>Monitoring for bleeding (B)</p> Signup and view all the answers

What is the pharmacologic class of warfarin?

<p>Vitamin K antagonist (A)</p> Signup and view all the answers

What is the primary adverse effect of warfarin?

<p>Bleeding (B)</p> Signup and view all the answers

What is the pregnancy category of warfarin?

<p>X (D)</p> Signup and view all the answers

What is the purpose of overlapping heparin therapy with warfarin?

<p>To ensure therapeutic anticoagulation (D)</p> Signup and view all the answers

What is the primary mechanism of action of direct thrombin inhibitors?

<p>Directly inhibiting thrombin (C)</p> Signup and view all the answers

What is the main concern when administering anticoagulants to patients with liver impairment?

<p>Elevated liver enzymes and bilirubin (C)</p> Signup and view all the answers

What is the primary indication for the use of heparin?

<p>Preventing excessive clotting within blood vessels (A)</p> Signup and view all the answers

Why is protamine sulfate used in the treatment of overdose?

<p>To neutralize heparin effects (A)</p> Signup and view all the answers

What is the primary side effect of anticoagulants?

<p>Bleeding (B)</p> Signup and view all the answers

Why is it essential to monitor the patient's activated partial thromboplastin time (aPTT) when administering heparin?

<p>To keep the value at 1.5 to 2 times the baseline (B)</p> Signup and view all the answers

What is the contraindication for dabigatran?

<p>Active bleeding (C)</p> Signup and view all the answers

Why is it essential to wait at least 18 hours following the last dose of rivaroxaban to remove an epidural catheter?

<p>To allow for the elimination of the drug from the system (D)</p> Signup and view all the answers

What is the primary interaction between heparin and other medications?

<p>Increased risk of bleeding (C)</p> Signup and view all the answers

What is the purpose of monitoring the patient's CBC and liver function tests when administering rivaroxaban?

<p>To monitor liver function and detect potential adverse effects (A)</p> Signup and view all the answers

Which of the following anticoagulants acts by directly inhibiting thrombin?

<p>Dabigatran (B)</p> Signup and view all the answers

What is the primary mechanism of action of heparin?

<p>Inactivate several clotting factors (C)</p> Signup and view all the answers

Which of the following is a major adverse effect of heparin administration during spinal or epidural anesthesia?

<p>Neurologic damage from hematoma (D)</p> Signup and view all the answers

What is the primary interaction between dabigatran and other medications?

<p>Increased risk of bleeding with other anticoagulants (C)</p> Signup and view all the answers

What is the therapeutic class of rivaroxaban?

<p>Anticoagulant (C)</p> Signup and view all the answers

What is the primary nursing consideration for patients taking heparin?

<p>Observe for bleeding (C)</p> Signup and view all the answers

What laboratory value should be monitored when administering heparin?

<p>Activated partial thromboplastin time (aPTT) (B)</p> Signup and view all the answers

What is the treatment of overdose for dabigatran?

<p>No antidote available (D)</p> Signup and view all the answers

What is the primary adverse effect of rivaroxaban?

<p>Bleeding (C)</p> Signup and view all the answers

What is the contraindication for heparin administration?

<p>Active internal bleeding (B)</p> Signup and view all the answers

What is the primary action of warfarin on the synthesis of clotting factors?

<p>Inhibits the synthesis of clotting factors II, VII, IX, and X (B)</p> Signup and view all the answers

Which of the following is a contraindication for warfarin therapy?

<p>Recent trauma (B)</p> Signup and view all the answers

What is the purpose of monitoring PT levels in patients on warfarin therapy?

<p>To monitor the effectiveness of warfarin therapy (A)</p> Signup and view all the answers

Which of the following herbal medications may interact with warfarin?

<p>Ginkgo (A)</p> Signup and view all the answers

What is the normal range for aPTT in individuals not receiving heparin therapy?

<p>30-40 seconds (A)</p> Signup and view all the answers

What is the primary mechanism of action of warfarin?

<p>Inhibiting the action of vitamin K (B)</p> Signup and view all the answers

Which of the following laboratory values is used to monitor the effectiveness of warfarin therapy?

<p>INR (C)</p> Signup and view all the answers

What is the pregnancy category of warfarin?

<p>X (D)</p> Signup and view all the answers

Which of the following is an adverse effect of warfarin therapy?

<p>Hepatitis (B)</p> Signup and view all the answers

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