10 Questions
What is the primary role of von Willebrand factor in blood coagulation?
Binding to the GP Ib receptor to facilitate platelet adhesion
In which environment do platelet-rich thrombi (white thrombi) tend to form?
High flow rate and high shear force environment of arteries
What is the consequence of occlusive arterial thrombi in blood coagulation?
Production of downstream ischemia of extremities or vital organs
Which substance is released from platelet granules and stumulates a conformational change in the IIb/IIIa receptor?
Serotonin (5-HT)
What type of defects in hemostasis result in bleeding from surface sites such as gingiva and skin?
Defects in primary hemostasis
What is the primary function of hemostasis?
Maintaining fluidity of blood and repairing vascular injury
What is a common cause of dysregulated hemostasis?
Hereditary or acquired defects in the clotting mechanism
Why is the use of anticoagulants common in the older population?
To address the high prevalence of chronic atrial fibrillation
What is the association between atrial fibrillation and blood clots?
Stasis of blood in the atria leading to thrombosis
What is the main risk associated with dysregulated hemostasis?
Thrombosis
Test your knowledge on drugs used in coagulation disorders with this quiz based on the lecture by Dr. Dessi James Ojascastro. Topics covered include hemostasis, anticoagulant drugs, fibrinolytic drugs, antiplatelet agents, and drugs used in bleeding disorders.
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