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Questions and Answers
What is the primary role of von Willebrand factor in blood coagulation?
What is the primary role of von Willebrand factor in blood coagulation?
- Binding to the GP Ib receptor to facilitate platelet adhesion (correct)
- Binding to thromboxane A2 to initiate platelet aggregation
- Adhering to the endothelial cell layer to prevent platelet activation
- Inducing a conformational change in the IIb/IIIa receptor
In which environment do platelet-rich thrombi (white thrombi) tend to form?
In which environment do platelet-rich thrombi (white thrombi) tend to form?
- High flow rate and high shear force environment of arteries (correct)
- Capillary environment with minimal shear force
- Venous environment with low shear force
- Low flow rate and low shear force environment of arteries
What is the consequence of occlusive arterial thrombi in blood coagulation?
What is the consequence of occlusive arterial thrombi in blood coagulation?
- Formation of large numbers of trapped red blood cells
- Recognition pathologically as red thrombi
- Production of downstream ischemia of extremities or vital organs (correct)
- Reduced risk of limb amputation or organ failure
Which substance is released from platelet granules and stumulates a conformational change in the IIb/IIIa receptor?
Which substance is released from platelet granules and stumulates a conformational change in the IIb/IIIa receptor?
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What type of defects in hemostasis result in bleeding from surface sites such as gingiva and skin?
What type of defects in hemostasis result in bleeding from surface sites such as gingiva and skin?
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What is the primary function of hemostasis?
What is the primary function of hemostasis?
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What is a common cause of dysregulated hemostasis?
What is a common cause of dysregulated hemostasis?
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Why is the use of anticoagulants common in the older population?
Why is the use of anticoagulants common in the older population?
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What is the association between atrial fibrillation and blood clots?
What is the association between atrial fibrillation and blood clots?
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What is the main risk associated with dysregulated hemostasis?
What is the main risk associated with dysregulated hemostasis?
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