PCC SOM 2026 Pharmacology and Therapeutics: Drugs Used in Coagulation Disorders Quiz

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Questions and Answers

What is the primary role of von Willebrand factor in blood coagulation?

  • Binding to the GP Ib receptor to facilitate platelet adhesion (correct)
  • Binding to thromboxane A2 to initiate platelet aggregation
  • Adhering to the endothelial cell layer to prevent platelet activation
  • Inducing a conformational change in the IIb/IIIa receptor

In which environment do platelet-rich thrombi (white thrombi) tend to form?

  • High flow rate and high shear force environment of arteries (correct)
  • Capillary environment with minimal shear force
  • Venous environment with low shear force
  • Low flow rate and low shear force environment of arteries

What is the consequence of occlusive arterial thrombi in blood coagulation?

  • Formation of large numbers of trapped red blood cells
  • Recognition pathologically as red thrombi
  • Production of downstream ischemia of extremities or vital organs (correct)
  • Reduced risk of limb amputation or organ failure

Which substance is released from platelet granules and stumulates a conformational change in the IIb/IIIa receptor?

<p>Serotonin (5-HT) (D)</p> Signup and view all the answers

What type of defects in hemostasis result in bleeding from surface sites such as gingiva and skin?

<p>Defects in primary hemostasis (B)</p> Signup and view all the answers

What is the primary function of hemostasis?

<p>Maintaining fluidity of blood and repairing vascular injury (A)</p> Signup and view all the answers

What is a common cause of dysregulated hemostasis?

<p>Hereditary or acquired defects in the clotting mechanism (C)</p> Signup and view all the answers

Why is the use of anticoagulants common in the older population?

<p>To address the high prevalence of chronic atrial fibrillation (B)</p> Signup and view all the answers

What is the association between atrial fibrillation and blood clots?

<p>Stasis of blood in the atria leading to thrombosis (D)</p> Signup and view all the answers

What is the main risk associated with dysregulated hemostasis?

<p>Thrombosis (D)</p> Signup and view all the answers

Flashcards

vWF's Primary Role

Binds to the GP Ib receptor to help platelets stick to damaged vessel walls.

Location of White Thrombi Formation

Arteries, due to the high speed and force of blood flow.

Consequence of Arterial Thrombi

It leads to reduced blood supply, causing ischemia in limbs or organs.

IIb/IIIa Receptor Change Stimulus

Serotonin (5-HT) prompts this change

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Cause of Surface Bleeding

Defects that hinder the early stages of clot formation.

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Primary Function of Hemostasis

Maintain blood's fluidity and fix injured blood vessels.

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Common Cause of Dysregulated Hemostasis

Hereditary or acquired defects in the clotting mechanism

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Atrial Fibrillation & Clots

Blood sits still, leading to clots.

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Main Risk of Dysregulated Hemostasis

The main danger is unwanted clot formation.

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