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PCC SOM 2026 Pharmacology and Therapeutics: Drugs Used in Coagulation Disorders Quiz

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PCC SOM 2026 Pharmacology and Therapeutics: Drugs Used in Coagulation Disorders Quiz

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Questions and Answers

What is the primary role of von Willebrand factor in blood coagulation?

Binding to the GP Ib receptor to facilitate platelet adhesion (correct)

Binding to thromboxane A2 to initiate platelet aggregation

Adhering to the endothelial cell layer to prevent platelet activation

Inducing a conformational change in the IIb/IIIa receptor

In which environment do platelet-rich thrombi (white thrombi) tend to form?

High flow rate and high shear force environment of arteries (correct)

Capillary environment with minimal shear force

Venous environment with low shear force

Low flow rate and low shear force environment of arteries

What is the consequence of occlusive arterial thrombi in blood coagulation?

Formation of large numbers of trapped red blood cells

Recognition pathologically as red thrombi

Production of downstream ischemia of extremities or vital organs (correct)

Reduced risk of limb amputation or organ failure

Which substance is released from platelet granules and stumulates a conformational change in the IIb/IIIa receptor?

Serotonin (5-HT) Signup and view all the answers

What type of defects in hemostasis result in bleeding from surface sites such as gingiva and skin?

Defects in primary hemostasis Signup and view all the answers

What is the primary function of hemostasis?

Maintaining fluidity of blood and repairing vascular injury Signup and view all the answers

What is a common cause of dysregulated hemostasis?

Hereditary or acquired defects in the clotting mechanism Signup and view all the answers

Why is the use of anticoagulants common in the older population?

To address the high prevalence of chronic atrial fibrillation Signup and view all the answers

What is the association between atrial fibrillation and blood clots?

Stasis of blood in the atria leading to thrombosis Signup and view all the answers

What is the main risk associated with dysregulated hemostasis?

Thrombosis Signup and view all the answers