Pathophysiology and Treatment of PMS
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Questions and Answers

Which neurotransmitter system is suggested to play a possible pathophysiologic role in PMS?

  • Opioid system
  • Dopamine system
  • GABA system
  • Serotonin system (correct)
  • What has been observed in women with PMS compared to normal women in terms of midcycle and luteal phase serum β-endorphin levels?

  • Higher levels
  • Similar levels
  • Fluctuating levels
  • Lower levels (correct)
  • What has been found in women with PMS in relation to platelet serotonin uptake and imipramine binding during the luteal phase?

  • Similar uptake and binding
  • Increased uptake and binding
  • Decreased uptake and binding (correct)
  • Variable uptake and binding
  • Which theory about the cause of PMS did S. Leon Israel propose?

    <p>Defective luteinization and progesterone deficiency</p> Signup and view all the answers

    What treatment did R.T. Frank apply to increase excretion of female sex hormones in PMS patients?

    <p>Calcium lactate, caffeine, and laxatives</p> Signup and view all the answers

    What is suggested strongly by the lasting response to oophorectomy in women unresponsive to medical therapy for PMS?

    <p>Role of ovarian steroid hormones</p> Signup and view all the answers

    What did studies comparing serum estrogen and progesterone levels fail to identify in women with and without PMS/PMDD?

    <p>Consistent differences</p> Signup and view all the answers

    What does the early onset of menses induced by treatment with a progesterone antagonist during the luteal phase not do in relation to the symptoms of PMS?

    <p>Decrease the symptoms</p> Signup and view all the answers

    What effect has been observed when exogenous estrogen or progesterone is added to the treatment regimen of women with PMS treated with a GnRH agonist?

    <p>Symptoms recur</p> Signup and view all the answers

    What has been found in women with PMS compared to normal women in terms of midcycle and luteal phase serum β-endorphin levels?

    <p>Lower midcycle and luteal phase serum β-endorphin levels in women with PMS</p> Signup and view all the answers

    What is the suggested pathophysiologic mechanism for PMS based on the information provided?

    <p>Abnormal response to normal cyclic changes in ovarian steroid hormone levels</p> Signup and view all the answers

    What has been observed in women with PMS compared to normal women in terms of whole blood serotonin concentrations and platelet serotonin uptake during the luteal phase?

    <p>Lower whole blood serotonin concentrations and platelet serotonin uptake in women with PMS</p> Signup and view all the answers

    What has been found regarding the effect of acute dietary tryptophan depletion on symptoms of PMS?

    <p>Aggravates symptoms of PMS</p> Signup and view all the answers

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