Pathology of Thyroid Gland: Goitre Definition, Types, and Morphology
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Questions and Answers

What is the pathogenesis of simple goitre?

  • Involution of follicular cells
  • Repeated cycles of iodine deficiency and correction
  • ↑ hormone synthesis + ↑ TSH Hyperplasia
  • Symmetrical diffuse enlargement of follicular cells (correct)

Which type of goitre is characterized by asymmetrical, nodular enlargement and irregular thyroid surface?

  • Multinodular goitre (correct)
  • Colloid goitre
  • Simple goitre
  • Toxic goitre

What is the characteristic microscopic feature of multinodular goitre?

  • Diffuse enlargement of thyroid follicles
  • Follicles lined by flat cells and filled with colloid
  • Variable sized nodules separated by fibrous tissue (correct)
  • Enlargement of follicular cells

What can repeated cycles of iodine deficiency and correction lead to in the thyroid?

<p>Symmetrical diffuse enlargement (C)</p> Signup and view all the answers

What is the primary cause of non-toxic endemic goitre?

<p>Increased demands during pregnancy, lactation, and puberty (C)</p> Signup and view all the answers

Which type of goitre is mostly caused by impaired thyroid hormone synthesis due to iodine deficiency?

<p>Endemic goitre (A)</p> Signup and view all the answers

What is the primary pathogenesis of diffuse colloid (simple) goitre?

<p>Impaired synthesis of thyroid hormones due to iodine deficiency (D)</p> Signup and view all the answers

Which factor is a common cause of sporadic non-toxic goitre in young females?

<p>Ingestion of substances like cabbage and cauliflower (D)</p> Signup and view all the answers

What is the specific feature of Graves disease that distinguishes it from other causes of hyperthyroidism?

<p>Exophthalmos (C)</p> Signup and view all the answers

Which of the following is a characteristic feature of Hashimoto’s thyroiditis?

<p>Atrophic follicles with intense lymphocytic infiltration (B)</p> Signup and view all the answers

What is the distinguishing feature of Subacute Granulomatous Thyroiditis?

<p>Transient self-limited nature (A)</p> Signup and view all the answers

Which neoplastic condition is associated with the development of goitre?

<p>Papillary thyroid carcinomas (B)</p> Signup and view all the answers

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