Patho colloquium 1 2023
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Questions and Answers

Which of the following is not an indicator for chronic lung congestion?

  • Alveolar septal fibrosis
  • Hemosiderin-laden macrophages in alveoli
  • Brownish color of the lung parenchyma
  • Inflammatory infiltrates of neutrophils (correct)
  • Increase in lung weight
  • Choose the correct answer about the layered composition of a thrombus.

  • Is typical for a blood clot as well
  • The lines are called Libman-Sacks
  • The lines are called Zahn's (correct)
  • Is present in thrombi as long as they occurred post-modem
  • The lines are called Trousseau's
  • In a person with edema, which of the following is true?

  • A primary heart disease may be of importance
  • A and B are correct
  • All answers are correct (correct)
  • A primary kidney disease may be significant
  • A primary liver disease may be an issue
  • Which of the following is not predisposed to by a premature birth?

    <p>Hemangiomas (C)</p> Signup and view all the answers

    Choose the correct answer.

    <p>A and B are correct (D)</p> Signup and view all the answers

    The pigment characteristic for previous exposure to stress is:

    <p>Lipofuscin (A)</p> Signup and view all the answers

    Hemosiderin granules can be easily identified with histochemical staining using which of the following reactions?

    <p>Pearl's reaction (Prussian blue) (B)</p> Signup and view all the answers

    A cessation of hormonal stimulation leads to:

    <p>Increase in Bax and Bak (D)</p> Signup and view all the answers

    The main condition to pronounce a lesion to be neoplastic (either benign or malignant) is:

    <p>The presence of poor differentiation (D)</p> Signup and view all the answers

    A sentinel lymph node:

    <p>Is the first one (or a group) to receive the lymph from the tumor area (A)</p> Signup and view all the answers

    What does ACPA stand for in terms of Rheumatoid Arthritis?

    <p>Antibodies (E)</p> Signup and view all the answers

    Beta2-microglobulin is:

    <p>The chemically related precursor protein in hemodialysis-associated amyloidosis (B)</p> Signup and view all the answers

    Choose the correct answer about AIDS:

    <p>It is the crisis phase of HIV infection (B)</p> Signup and view all the answers

    A 22-year-old man develops marked right lower quadrant abdominal pain over the past day. On physical examination, there is rebound tenderness on palpation over the right lower quadrant. Laparoscopic surgery is performed, and the appendix is swollen, erythematous, and partly covered by a yellowish exudate. It is removed, and a microscopic section shows infiltration with numerous neutrophils. The pain experienced by this patient is predominantly the result of which of the following two chemical mediators?

    <p>Prostaglandin and bradykinin (A)</p> Signup and view all the answers

    A 94-year-old woman has developed a fever and cough over the past 2 days. Staphylococcus aureus is cultured from the sputum. She received a course of antibiotic therapy. Two weeks later, she no longer has a productive cough but she still... A chest radiograph reveals a 3 cm rounded density in the right lower lobe who... Liquefied contents form a central air-fluid level. There are no surrounding infections (...). Which of the following is the best description for this outcome of her pneumonia (...)?

    <p>Abscess formation (E)</p> Signup and view all the answers

    A 19-year-old woman who walks indoors spends her day outside gardening. Basically, she kind of got an allergy. Which of the following chemical changes most likely accounts for her red appearance?

    <p>Vasodilation (B)</p> Signup and view all the answers

    A 43-year-old woman has had a chronic cough with fever and weight loss for the past month. A chest radiograph reveals multiple modules from 1 to 4 cm in size, some of which demonstrate cavitations in the upper lobes. A sputum sample reveals the presence of acid-fast bacilli. Which of the following cells is the most important in the development of her lung lesions?

    <p>Macrophage (C)</p> Signup and view all the answers

    A 21-year-old sexually active man is notified by the health department that his last sexual contact 3 weeks prior has a positive serologic test for syphilis. He goes to see a physician that day. Which of the following findings in this man is most likely to be indicative of his acquisition of this infection?

    <p>Genital condyloma lata (E)</p> Signup and view all the answers

    What is a predictive biomarker for breast cancer patients?

    <p>BRCA 1 &amp; 2</p> Signup and view all the answers

    Select the correct answer regarding molecular biology techniques?

    <p>All answers are correct (B)</p> Signup and view all the answers

    Select the correct order of stages in a pathomorphology laboratory.

    <p>Transport and admission, description, collecting representative pieces from specimens, tissue processing, embedding, sectioning, staining, microscopic evaluation (D)</p> Signup and view all the answers

    What is the first step in the chambers of tissue processing machines?

    <p>Dehydration (C)</p> Signup and view all the answers

    What is the ideal cutting section thickness in histopathology?

    <p>4-6µm (B)</p> Signup and view all the answers

    Venous thrombosis:

    <p>Damages tissues through local blood flow obstruction (C)</p> Signup and view all the answers

    The Nutmeg Liver:

    <p>Grossly is a double-colored liver (yellow-red) (B)</p> Signup and view all the answers

    Pneumatosis intestinalis is a morphological feature of:

    <p>NEC (D)</p> Signup and view all the answers

    The malignant pediatric neoplasm that may spontaneously regress is:

    <p>Neuroblastoma (D)</p> Signup and view all the answers

    A Barrett metaplasia is:

    <p>Glandular metaplasia of esophageal squamous epithelium (D)</p> Signup and view all the answers

    The highest mortality among cancers is attributed to:

    <p>Female lung cancer (B)</p> Signup and view all the answers

    Which stain is most commonly used in cytology?

    <p>Papanicolaou stain (A)</p> Signup and view all the answers

    What is considered as the best type of material for molecular biology staining?

    <p>Fresh or frozen tissues (A)</p> Signup and view all the answers

    Classical prognostic factors in the case of many tumors are:

    <p>All of the above (E)</p> Signup and view all the answers

    Serum biomarker for pancreatic cancer is:

    <p>KRAS (D)</p> Signup and view all the answers

    Choose a predictive biomarker for breast cancer patients:

    <p>BRCA1/2 (C)</p> Signup and view all the answers

    Choose the correct statement about nephroblastoma:

    <p>Its another name is Wilms tumor (C)</p> Signup and view all the answers

    Choose the correct statement:

    <p>In HE staining are eosinophilic (A)</p> Signup and view all the answers

    In the proliferative phase of hyaline membrane disease of newborn:

    <p>Proliferation/hyperplasia of type II pneumocytes is observed (D)</p> Signup and view all the answers

    Flashcards

    Chronic lung congestion indicator

    C. Inflammatory infiltrates of neutrophils

    Thrombus composition

    E. the lines are called Zahn's

    Causes of edema

    E. all answers are correct

    Premature birth complications

    D. Hemangiomas

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    Necrosis types related to RDS & NEC

    E. a and b are correct

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    Stress pigment

    A. lipofuscin

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    Hemosiderin staining

    A. Pearl's reaction (Prussian blue)

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    Hormonal stimulation and apoptosis

    A. increase in Bax and Bak

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    Neoplastic lesion condition

    C. the presence of poor differentiation

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    Sentinel lymph node definition

    A. is the first one (or a group) to receive the lymph from the tumor area

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    ACPA in Rheumatoid Arthritis

    A. antibodies

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    Beta2-microglobulin role

    A. The chemically related precursor protein in hemodialysis- associated amyloidosis

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    AIDS definition

    A. It is the crisis phase of HIV infection

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    Appendicitis chemical mediators

    D. Prostaglandin and bradykinin

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    Pneumonia outcome description

    B. Abscess formation

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    Chemical change from gardening allergy

    E. Vasodilation

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    Cell important in lung lesions development

    A. Macrophage

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    Syphilis indicative finding

    C. Mucocutaneous rash

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    Breast cancer predictive biomarker

    C. BRCA1/2

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    Molecular biology techniques

    E. All answers are correct

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    Pathomorphology laboratory stages

    B. Transport and admission, description,...

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    Tissue processing machines' first step

    B. Dehydration

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    Ideal tissue cutting thickness

    C. 4-6um

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    Venous thrombosis impact

    E. Damages tissues through local blood flow obstruction

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    Nutmeg liver condition

    D. Is an example of a complete adaptation of hepatocytes to a chronic injury

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    Pneumatosis intestinalis association

    D. NEC

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    Neoplastic regression in pediatrics

    C. Neuroblastoma

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    Barrett metaplasia definition

    A. Glandular metaplasia of esophageal squamous epithelium

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    Highest cancer mortality

    A. Female lung cancer

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    Cytology stain usage

    A. Papanicolaou stain

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    Best material for molecular staining

    A. Fresh or frozen tissues

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    Key tumor prognostic factors

    E. All of the above

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    Pancreatic cancer serum biomarker

    C. CA19.9

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    Predictive biomarkers for breast cancer

    C. BRCA1/2

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    Nephroblast characteristics

    D. Its another name is wilms tumor

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    HE staining eosinophilic feature

    B. In HE staining are eosinophilic

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    Proliferative phase in HMD

    D. Proliferation / hyperplasia of type II pneumocytes is observed

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    Study Notes

    Chronic Lung Congestion Indicators

    • Alveolar septal fibrosis is an indicator.
    • Increased lung weight is an indicator.
    • Inflammatory infiltrates of neutrophils are not an indicator.
    • Hemosiderin-laden macrophages in alveoli are an indicator.
    • Brownish color of the lung parenchyma is an indicator.

    Thrombus Layered Composition

    • Thrombi have lines called Zahn's lines.

    Edema Causes

    • Primary heart disease, kidney disease, or liver disease can contribute to edema.

    Premature Birth Predispositions

    • Necrotizing enterocolitis (NEC) is a predisposition.
    • Respiratory distress syndrome (RDS) is a predisposition.
    • Sudden infant death syndrome (SIDS) is a predisposition.
    • Hemangiomas are not a predisposition.
    • Death within the first year of life is a predisposition.

    Necrosis in Conditions

    • Necrosis of alveolar epithelium may be a factor in RDS.
    • Liquefactive necrosis of colon mucosa may occur in NEC.
    • Ischemic necrosis of cardiomyocytes may cause hydrops universalis.
    • Necrosis of brain basal ganglia may cause kernicterus.
    • Lipofuscin is a pigment associated with stress.

    Hemosiderin Granule Staining

    • Pearl's reaction (Prussian blue) is a useful stain for hemosiderin granules.

    Hormonal Cessation Effects

    • Cessation of hormonal stimulation leads to an increase in Bax and Bak.

    Neoplastic Lesion Criteria

    • Poor differentiation is a key criterion for identifying a neoplastic lesion.

    Sentinel Lymph Node Function

    • A sentinel lymph node is the first node(s) to receive lymph from the tumor area.

    ACPA in Rheumatoid Arthritis

    • ACPA stands for anti-citrullinated protein antibodies.

    Beta2-Microglobulin and Amyloidosis

    • Beta2-microglobulin is a chemically related precursor protein in hemodialysis-associated amyloidosis.

    AIDS Stages

    • AIDS is the crisis phase of HIV infection.

    Appendicitis Pain Mediators

    • Prostaglandins and bradykinin are key chemical mediators in appendicitis pain.

    Pneumonia Outcome

    • Abscess formation can result from pneumonia.

    Allergic Reaction Appearance

    • Vasodilation is the primary factor in the reddened appearance.

    Lung Lesions in Tuberculosis

    • Macrophages are the most crucial cells in the development of lung lesions due to tuberculosis.

    Syphilis Diagnosis

    • A positive VDRL in the cerebrospinal fluid (CSF) strongly suggests neurosyphilis.

    Breast Cancer Predictive Biomarker

    • BRCA1 and BRCA2 are predictive biomarkers for breast cancer.

    Molecular Biology Techniques

    • Molecular biology techniques study nucleic acids (DNA and RNA).
    • They can be qualitative or quantitative.
    • Techniques include PCR and FISH.

    Tissue Processing Steps

    • Tissue processing begins with transport and admission of specimens.
    • Collecting representative pieces from specimens is the next step.
    • Tissue processing, embedding, sectioning, staining, and microscopic evaluation follow.

    Tissue Processing Machine Steps

    • Dehydration is the initial step in tissue processing machines.

    Histopathology Section Thickness

    • The ideal histopathology section thickness is 4-6 μm.

    Venous Thrombosis

    • Venous thrombosis frequently affects deep veins of lower limbs.
    • It causes local blood flow obstruction.

    Nutmeg Liver

    • A nutmeg liver is a hallmark of chronic liver congestion.
    • It's grossly a double-colored liver (yellow-red).

    Pneumatosis Intestinalis and NEC

    • Pneumatosis intestinalis is a characteristic of necrotizing enterocolitis (NEC).

    Pediatric Malignant Neoplasm Regression

    • Neuroblastoma is a pediatric malignant neoplasm that can spontaneously regress (may disappear).

    Barrett's Metaplasia

    • Barrett's metaplasia involves glandular metaplasia of esophageal squamous epithelium.

    Highest Cancer Mortality

    • Female lung cancer has the highest mortality rate among cancers.

    Cytology Staining

    • Papanicolaou stain is the most common stain used in cytology.

    Molecular Biology Staining Materials

    • Fresh or frozen tissues are the best materials for molecular biology staining.

    Prognostic Factors in Tumors

    • Tumor grade, tumor stage, status of surgical margins, and lymphovascular space invasion are all prognostic tumor factors.

    Pancreatic Cancer Biomarker

    • CA19.9 is a serum biomarker for pancreatic cancer.

    Breast Cancer Predictive Biomarker

    • BRCA1/2 are predictive biomarkers for breast cancer.

    Nephroblastoma Characteristics

    • Nephroblastoma (Wilms tumor) is a common pediatric tumor.
    • It typically shows a triphasic morphology (epithelial, stromal, and blastemal components).

    Histological Appearance in NEC

    • Eosinophilic tissues are common in the mucosa of the small intestine in NEC.

    Hyaline Membrane Disease Stages

    • Proliferation/hyperplasia of type II pneumocytes is the hallmark of the proliferative phase of hyaline membrane disease.

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    Description

    Test your knowledge on chronic lung congestion indicators, thrombus composition, edema causes, and premature birth predispositions. This quiz covers critical concepts in pathology, from necrosis to conditions affecting newborns.

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