9 Questions
What is the main reason behind the loss of beta cells in Type 1 Diabetes Mellitus (T1DM)?
Autoimmune destruction
Which human leukocyte antigen (HLA) accounts for approximately 60% of the risk for T1DM?
HLA-DR3
What is the protective genetic profile associated with a reduced risk of T1DM?
HLA-DQA1-0102, DQB1-0602
Which of the following viruses is NOT associated with contributing to the development of T1DM?
Rubella virus
What are the pathological changes seen in the prediabetic stage of T1DM?
Insulitis - autoimmune mononuclear inflammation of islet cells
Which type of immune response characterizes the development of T1DM?
Cell-mediated immune response
Glutamic Acid Decarboxylase (GAD) molecules are involved in a phenomenon of molecular mimicry with which virus in T1DM?
Coxsackie B virus
Autoantibodies against which proteins are involved in the autoimmune destruction of beta cells in T1DM?
Insulin, GAD
Which genetic factors contribute majorly to the risk for Type 1 Diabetes Mellitus (T1DM)?
CTLA4, INS genes
This quiz covers the pathogenesis of Type 1 Diabetes Mellitus, focusing on the loss of insulin-producing beta cells and the factors involved such as genetics, environment, and autoimmunity. Learn about the autoimmune destruction with antibodies against insulin and islet proteins.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
