Pathogenesis of Type 1 Diabetes Mellitus
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Questions and Answers

What is the main reason behind the loss of beta cells in Type 1 Diabetes Mellitus (T1DM)?

  • Genetic mutations
  • Autoimmune destruction (correct)
  • Insulin resistance
  • Environmental toxins
  • Which human leukocyte antigen (HLA) accounts for approximately 60% of the risk for T1DM?

  • HLA-DQ8
  • HLA-DR3 (correct)
  • HLA-DP5
  • HLA-DR2
  • What is the protective genetic profile associated with a reduced risk of T1DM?

  • HLA-DQA1-0102, DQB1-0602 (correct)
  • HLA-DR4
  • HLA-DQB1-0301
  • HLA-DQ5
  • Which of the following viruses is NOT associated with contributing to the development of T1DM?

    <p>Rubella virus</p> Signup and view all the answers

    What are the pathological changes seen in the prediabetic stage of T1DM?

    <p>Insulitis - autoimmune mononuclear inflammation of islet cells</p> Signup and view all the answers

    Which type of immune response characterizes the development of T1DM?

    <p><strong>Cell-mediated</strong> immune response</p> Signup and view all the answers

    Glutamic Acid Decarboxylase (GAD) molecules are involved in a phenomenon of molecular mimicry with which virus in T1DM?

    <p><strong>Coxsackie B virus</strong></p> Signup and view all the answers

    Autoantibodies against which proteins are involved in the autoimmune destruction of beta cells in T1DM?

    <p><strong>Insulin</strong>, <strong>GAD</strong></p> Signup and view all the answers

    Which genetic factors contribute majorly to the risk for Type 1 Diabetes Mellitus (T1DM)?

    <p><strong>CTLA4</strong>, <strong>INS</strong> genes</p> Signup and view all the answers

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