Particle Size in Pharmaceuticals Quiz
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Questions and Answers

Which diameter is defined as the diameter of a sphere having the same settling velocity as the particle of interest?

  • Stokes’ diameter (correct)
  • Feret’s diameter
  • Projected area diameter
  • Aerodynamic diameter

    • What is the term for particles of the same size?

  • Polydisperse
  • Micrometre
  • Monodispersed (correct)
  • Isometric

    • Which method is used to find the diameter of irregular particles?

  • Projected area diameter
  • Feret’s diameter
  • Equivalent volume diameter
  • Aerodynamic diameter (correct)

    • What is Martin’s diameter?

    <p>The length of a line that divides a particle into two equal halves</p> Signup and view all the answers

    What is a weakness of optical microscopy compared to scanning electron microscopy (SEM)?

    <p>Limited resolution (0.2-0.5μm)</p> Signup and view all the answers

    What is a strength of sieving as a quantitative analysis method?

    <p>Simple, quick, and inexpensive</p> Signup and view all the answers

    What is a weakness of the Andreasen apparatus?

    <p>Lower limit around 1 μm</p> Signup and view all the answers

    What is a strength of scanning electron microscopy (SEM) compared to optical microscopy?

    <p>High resolution (1-20 nm)</p> Signup and view all the answers

    Which diameter is defined as the length of a line that divides a particle into two equal halves?

    <p>Martin’s diameter</p> Signup and view all the answers

    What is the term for particles of different sizes?

    <p>Polydisperse</p> Signup and view all the answers

    Which method of particle sizing relates all diameters and is used to find the diameter of irregular particles?

    <p>Aerodynamic diameter</p> Signup and view all the answers

    What is the diameter of a sphere having the same settling velocity as the particle of interest, used to find the size of particles?

    <p>Stokes’ diameter</p> Signup and view all the answers

    What is a limitation of optical microscopy for quantitative analysis?

    <p>Limited resolution of 0.2-0.5μm</p> Signup and view all the answers

    What is a weakness shared by both scanning electron microscopy (SEM) and optical microscopy?

    <p>Inability to distinguish overlapping particles or agglomerates</p> Signup and view all the answers

    What is a limitation of sieving as a quantitative analysis method?

    <p>Lower size limit of 25-50μm</p> Signup and view all the answers

    What is a strength of the Andreasen apparatus for particle analysis?

    <p>Direct measurement of stokes diameter</p> Signup and view all the answers

    What is the term for particles of different sizes?

    <p>Polydisperse</p> Signup and view all the answers

    What is Martin’s diameter?

    <p>Length of a line that divides particle into leave into halves</p> Signup and view all the answers

    What is the diameter of a sphere having the same settling velocity as the particle of interest, used to find the size of particles?

    <p>Stokes’ diameter</p> Signup and view all the answers

    What is a strength of scanning electron microscopy (SEM) compared to optical microscopy?

    <p>Higher resolution for smaller particles</p> Signup and view all the answers

    What is a weakness shared by both scanning electron microscopy (SEM) and optical microscopy?

    <p>Low resolution</p> Signup and view all the answers

    What is a strength of sieving as a quantitative analysis method?

    <p>Wide particle size range</p> Signup and view all the answers

    What is a limitation of the Andreasen apparatus?

    <p>Lower limit around 1μm</p> Signup and view all the answers

    What is a strength of optical microscopy for qualitative analysis?

    <p>Ability to visualize and quickly analyze samples</p> Signup and view all the answers

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