Particle Size in Pharmaceuticals Quiz
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Questions and Answers

Which diameter is defined as the diameter of a sphere having the same settling velocity as the particle of interest?

  • Stokes’ diameter (correct)
  • Feret’s diameter
  • Projected area diameter
  • Aerodynamic diameter

What is the term for particles of the same size?

  • Polydisperse
  • Micrometre
  • Monodispersed (correct)
  • Isometric

Which method is used to find the diameter of irregular particles?

  • Projected area diameter
  • Feret’s diameter
  • Equivalent volume diameter
  • Aerodynamic diameter (correct)

What is Martin’s diameter?

<p>The length of a line that divides a particle into two equal halves (B)</p> Signup and view all the answers

What is a weakness of optical microscopy compared to scanning electron microscopy (SEM)?

<p>Limited resolution (0.2-0.5μm) (D)</p> Signup and view all the answers

What is a strength of sieving as a quantitative analysis method?

<p>Simple, quick, and inexpensive (B)</p> Signup and view all the answers

What is a weakness of the Andreasen apparatus?

<p>Lower limit around 1 μm (C)</p> Signup and view all the answers

What is a strength of scanning electron microscopy (SEM) compared to optical microscopy?

<p>High resolution (1-20 nm) (D)</p> Signup and view all the answers

Which diameter is defined as the length of a line that divides a particle into two equal halves?

<p>Martin’s diameter (D)</p> Signup and view all the answers

What is the term for particles of different sizes?

<p>Polydisperse (D)</p> Signup and view all the answers

Which method of particle sizing relates all diameters and is used to find the diameter of irregular particles?

<p>Aerodynamic diameter (C)</p> Signup and view all the answers

What is the diameter of a sphere having the same settling velocity as the particle of interest, used to find the size of particles?

<p>Stokes’ diameter (A)</p> Signup and view all the answers

What is a limitation of optical microscopy for quantitative analysis?

<p>Limited resolution of 0.2-0.5μm (C)</p> Signup and view all the answers

What is a weakness shared by both scanning electron microscopy (SEM) and optical microscopy?

<p>Inability to distinguish overlapping particles or agglomerates (C)</p> Signup and view all the answers

What is a limitation of sieving as a quantitative analysis method?

<p>Lower size limit of 25-50μm (B)</p> Signup and view all the answers

What is a strength of the Andreasen apparatus for particle analysis?

<p>Direct measurement of stokes diameter (A)</p> Signup and view all the answers

What is the term for particles of different sizes?

<p>Polydisperse (C)</p> Signup and view all the answers

What is Martin’s diameter?

<p>Length of a line that divides particle into leave into halves (C)</p> Signup and view all the answers

What is the diameter of a sphere having the same settling velocity as the particle of interest, used to find the size of particles?

<p>Stokes’ diameter (D)</p> Signup and view all the answers

What is a strength of scanning electron microscopy (SEM) compared to optical microscopy?

<p>Higher resolution for smaller particles (D)</p> Signup and view all the answers

What is a weakness shared by both scanning electron microscopy (SEM) and optical microscopy?

<p>Low resolution (D)</p> Signup and view all the answers

What is a strength of sieving as a quantitative analysis method?

<p>Wide particle size range (A)</p> Signup and view all the answers

What is a limitation of the Andreasen apparatus?

<p>Lower limit around 1μm (C)</p> Signup and view all the answers

What is a strength of optical microscopy for qualitative analysis?

<p>Ability to visualize and quickly analyze samples (C)</p> Signup and view all the answers

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