Drug Absorption and Particle Size Quiz
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Questions and Answers

How does particle size reduction affect the effective surface area of the drug?

  • It decreases the effective surface area
  • It slightly increases the effective surface area
  • It increases the effective surface area enormously (correct)
  • It has no effect on the effective surface area
  • What is the impact of micronized particle size on the absorption of low aqueous solubility drugs?

  • It only affects specific drugs
  • It decreases absorption rates
  • It increases absorption rates (correct)
  • It has no effect on absorption rates
  • Why might a disintegrant be added to the formulation of poorly soluble drugs?

  • To decrease the water penetration into the particles
  • To ensure rapid disintegration of the tablet and release of the particles (correct)
  • To reduce the dissolution rates
  • To limit the total surface area of the particles
  • What is a limitation of extensive particle size reduction for poorly soluble, hydrophobic drugs?

    <p>It increases the tendency of particles to aggregate in aqueous GIT fluids</p> Signup and view all the answers

    Why might increased rate of dissolution be undesirable for certain drugs like penicillin G and erythromycin?

    <p>It results in increased drug degradation</p> Signup and view all the answers

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