5 Questions
How does particle size reduction affect the effective surface area of the drug?
It increases the effective surface area enormously
What is the impact of micronized particle size on the absorption of low aqueous solubility drugs?
It increases absorption rates
Why might a disintegrant be added to the formulation of poorly soluble drugs?
To ensure rapid disintegration of the tablet and release of the particles
What is a limitation of extensive particle size reduction for poorly soluble, hydrophobic drugs?
It increases the tendency of particles to aggregate in aqueous GIT fluids
Why might increased rate of dissolution be undesirable for certain drugs like penicillin G and erythromycin?
It results in increased drug degradation
Test your knowledge on the relationship between particle size reduction and drug absorption. Learn about the impact of micronization on the bioavailability of certain drugs such as griseofulvin, nitrofurantoin, and steroids.
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