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Questions and Answers
How does particle size reduction affect the effective surface area of the drug?
How does particle size reduction affect the effective surface area of the drug?
- It decreases the effective surface area
- It slightly increases the effective surface area
- It increases the effective surface area enormously (correct)
- It has no effect on the effective surface area
What is the impact of micronized particle size on the absorption of low aqueous solubility drugs?
What is the impact of micronized particle size on the absorption of low aqueous solubility drugs?
- It only affects specific drugs
- It decreases absorption rates
- It increases absorption rates (correct)
- It has no effect on absorption rates
Why might a disintegrant be added to the formulation of poorly soluble drugs?
Why might a disintegrant be added to the formulation of poorly soluble drugs?
- To decrease the water penetration into the particles
- To ensure rapid disintegration of the tablet and release of the particles (correct)
- To reduce the dissolution rates
- To limit the total surface area of the particles
What is a limitation of extensive particle size reduction for poorly soluble, hydrophobic drugs?
What is a limitation of extensive particle size reduction for poorly soluble, hydrophobic drugs?
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Why might increased rate of dissolution be undesirable for certain drugs like penicillin G and erythromycin?
Why might increased rate of dissolution be undesirable for certain drugs like penicillin G and erythromycin?
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