Parkinson's Disease Pathology and Clinical Features
10 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What has been associated with a 50% reduced risk of developing PD?

  • Environmental toxins
  • Genetic mutations in genes like SNCA, PRKN, LRRK2, and PINK1
  • Vagotomy (correct)
  • Dopamine replacement therapy using levodopa and dopamine agonists
  • Which neurotransmitter is thought to underlie many of the motor symptoms seen in PD patients?

  • Acetylcholine
  • Serotonin
  • Dopamine (correct)
  • Norepinephrine
  • What has been found to increase microglial TLR4 expression and markers of activation in PD?

  • Dopamine replacement therapy
  • Vagotomy
  • Environmental toxins
  • Alpha-synuclein (correct)
  • Which area of research focuses on deep brain stimulation, neurotrophic factors, and stem cell transplantation for PD?

    <p>Emerging and experimental therapies</p> Signup and view all the answers

    Where are Lewy bodies known to first occur in relation to PD?

    <p>Vagal nerve</p> Signup and view all the answers

    What is the key pathological feature of Parkinson's disease involving the accumulation of Lewy bodies?

    <p>Increased reactive microglia</p> Signup and view all the answers

    Which area of the brain experiences the initial loss of dopamine neurons in Parkinson's disease?

    <p>Substantia nigra pars compacta</p> Signup and view all the answers

    What non-motor symptom is associated with Parkinson's disease?

    <p>Dementia</p> Signup and view all the answers

    Which area experiences a loss of dopamine innervation due to the loss of dopamine-producing neurons in Parkinson's disease?

    <p>Striatum</p> Signup and view all the answers

    How is Parkinson's disease typically diagnosed?

    <p>Neuroimaging techniques or immunohistochemistry after death</p> Signup and view all the answers

    More Like This

    Parkinson's Disease Pathology
    10 questions
    Parkinson's Disease Overview
    12 questions
    Parkinson Disease Overview
    36 questions
    Use Quizgecko on...
    Browser
    Browser