10 Questions
What has been associated with a 50% reduced risk of developing PD?
Vagotomy
Which neurotransmitter is thought to underlie many of the motor symptoms seen in PD patients?
Dopamine
What has been found to increase microglial TLR4 expression and markers of activation in PD?
Alpha-synuclein
Which area of research focuses on deep brain stimulation, neurotrophic factors, and stem cell transplantation for PD?
Emerging and experimental therapies
Where are Lewy bodies known to first occur in relation to PD?
Vagal nerve
What is the key pathological feature of Parkinson's disease involving the accumulation of Lewy bodies?
Increased reactive microglia
Which area of the brain experiences the initial loss of dopamine neurons in Parkinson's disease?
Substantia nigra pars compacta
What non-motor symptom is associated with Parkinson's disease?
Dementia
Which area experiences a loss of dopamine innervation due to the loss of dopamine-producing neurons in Parkinson's disease?
Striatum
How is Parkinson's disease typically diagnosed?
Neuroimaging techniques or immunohistochemistry after death
Test your knowledge about the pathology and clinical features of Parkinson's disease, including the loss of dopamine-producing neurons, accumulation of Lewy bodies, and clinical manifestations. Explore the key pathological and clinical aspects of this neurodegenerative disorder.
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