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Pathology and Clinical Features of Parkinson's Disease

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Pathology and Clinical Features of Parkinson's Disease

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Questions and Answers

Which characteristic is not associated with the pathology of Parkinson's Disease?

Increased dopamine innervation in the cortex (correct)

Loss of neuromelanin

Accumulation of Lewy bodies containing alpha-synuclein

Death of astrocytes

What is the main role of the gut and vagus nerve in Parkinson's Disease?

Trigger Lewy body accumulation in the substantia nigra pars compacta

Contribute to the development of non-motor symptoms (correct)

Directly produce dopamine for replacement therapy

Prevent the loss of dopamine-producing neurons in the midbrain

Which gene mutation is NOT associated with familial Parkinson's Disease?

LRRK2

APP (correct)

SNCA

PRKN

What is the potential impact of vagotomy on Parkinson's Disease development?

50% reduced risk of developing Parkinson's Disease Signup and view all the answers

Which treatment is NOT part of the non-dopaminergic agents for motor/non-motor symptoms in Parkinson's Disease?

Dopamine replacement therapy Signup and view all the answers

What is considered an early cause rather than a late consequence of Parkinson's Disease?

Microglial activation Signup and view all the answers

Which receptor family excites neurons in the context of dopamine neurotransmission?

$D1$ Signup and view all the answers

What is the primary abnormal motor feature associated with Parkinson's Disease?

Resting tremor Signup and view all the answers

In which region does the progressive loss of dopamine producing neurons occur in Parkinson's Disease?

$Substantia$ $nigra$ $pars$ $compacta$ Signup and view all the answers

Which neuroinflammatory process is increased in a mouse model of Parkinson's Disease?

$Microglial$ $activation$ Signup and view all the answers