10 Questions
Which characteristic is not associated with the pathology of Parkinson's Disease?
Increased dopamine innervation in the cortex
What is the main role of the gut and vagus nerve in Parkinson's Disease?
Contribute to the development of non-motor symptoms
Which gene mutation is NOT associated with familial Parkinson's Disease?
APP
What is the potential impact of vagotomy on Parkinson's Disease development?
50% reduced risk of developing Parkinson's Disease
Which treatment is NOT part of the non-dopaminergic agents for motor/non-motor symptoms in Parkinson's Disease?
Dopamine replacement therapy
What is considered an early cause rather than a late consequence of Parkinson's Disease?
Microglial activation
Which receptor family excites neurons in the context of dopamine neurotransmission?
$D1$
What is the primary abnormal motor feature associated with Parkinson's Disease?
Resting tremor
In which region does the progressive loss of dopamine producing neurons occur in Parkinson's Disease?
$Substantia$ $nigra$ $pars$ $compacta$
Which neuroinflammatory process is increased in a mouse model of Parkinson's Disease?
$Microglial$ $activation$
Learn about the progressive loss of dopamine producing neurons in the midbrain and the clinical features associated with Parkinson's Disease. Understand the characteristics including loss of neuromelanin, accumulation of Lewy bodies, and abnormal motor features.
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