Parkinson's Disease Pathology
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Questions and Answers

Which neurotransmitter is primarily affected in Parkinson's disease?

  • Dopamine (correct)
  • GABA
  • Acetylcholine
  • Serotonin

What is the role of the vagus nerve in Parkinson's disease?

  • It inhibits dopamine release
  • It regulates GABA levels
  • It connects the gut and brainstem regions (correct)
  • It is involved in serotonin release

Which genetic mutations are associated with familial Parkinson's disease?

  • SNCA, PRKN, LRRK2, PINK1 (correct)
  • BRCA1, BRCA2
  • HBB, HBA1
  • APP, PSEN1

What has been suggested as a potential early driver of Parkinson's disease neurodegeneration?

<p>Neuroimmune activation (C)</p> Signup and view all the answers

Which type of receptors coupled to Gi proteins inhibit neurons in Parkinson's disease?

<p>D2-like receptors (D2, D3, D4) (A)</p> Signup and view all the answers

Which area of the brain experiences the initial loss of dopamine neurons in Parkinson's disease?

<p>Substantia nigra pars compacta (B)</p> Signup and view all the answers

What is the main protein found in Lewy bodies associated with Parkinson's disease?

<p>Alpha-synuclein (A)</p> Signup and view all the answers

Which of the following is not a clinical motor feature of Parkinson's disease?

<p>Memory loss (B)</p> Signup and view all the answers

What is the primary method for diagnosing Parkinson's disease?

<p>Clinical symptoms assessment by a neurologist (A)</p> Signup and view all the answers

What are the non-motor features associated with Parkinson's disease?

<p>Loss of appetite, reduced gastric motility, emotional and behavioral changes (C)</p> Signup and view all the answers

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