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Parkinson's Disease Pathology

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Questions and Answers

Which neurotransmitter is primarily affected in Parkinson's disease?

Dopamine (correct)

GABA

Acetylcholine

Serotonin

What is the role of the vagus nerve in Parkinson's disease?

It inhibits dopamine release

It regulates GABA levels

It connects the gut and brainstem regions (correct)

It is involved in serotonin release

Which genetic mutations are associated with familial Parkinson's disease?

SNCA, PRKN, LRRK2, PINK1 (correct)

BRCA1, BRCA2

HBB, HBA1

APP, PSEN1

What has been suggested as a potential early driver of Parkinson's disease neurodegeneration?

Neuroimmune activation Signup and view all the answers

Which type of receptors coupled to Gi proteins inhibit neurons in Parkinson's disease?

D2-like receptors (D2, D3, D4) Signup and view all the answers

Which area of the brain experiences the initial loss of dopamine neurons in Parkinson's disease?

Substantia nigra pars compacta Signup and view all the answers

What is the main protein found in Lewy bodies associated with Parkinson's disease?

Alpha-synuclein Signup and view all the answers

Which of the following is not a clinical motor feature of Parkinson's disease?

Memory loss Signup and view all the answers

What is the primary method for diagnosing Parkinson's disease?

Clinical symptoms assessment by a neurologist Signup and view all the answers

What are the non-motor features associated with Parkinson's disease?

Loss of appetite, reduced gastric motility, emotional and behavioral changes Signup and view all the answers