10 Questions
Which neurotransmitter is primarily affected in Parkinson's disease?
Dopamine
What is the role of the vagus nerve in Parkinson's disease?
It connects the gut and brainstem regions
Which genetic mutations are associated with familial Parkinson's disease?
SNCA, PRKN, LRRK2, PINK1
What has been suggested as a potential early driver of Parkinson's disease neurodegeneration?
Neuroimmune activation
Which type of receptors coupled to Gi proteins inhibit neurons in Parkinson's disease?
D2-like receptors (D2, D3, D4)
Which area of the brain experiences the initial loss of dopamine neurons in Parkinson's disease?
Substantia nigra pars compacta
What is the main protein found in Lewy bodies associated with Parkinson's disease?
Alpha-synuclein
Which of the following is not a clinical motor feature of Parkinson's disease?
Memory loss
What is the primary method for diagnosing Parkinson's disease?
Clinical symptoms assessment by a neurologist
What are the non-motor features associated with Parkinson's disease?
Loss of appetite, reduced gastric motility, emotional and behavioral changes
Test your knowledge of Parkinson's disease pathology, including the loss of dopamine-producing neurons, key pathological features, and clinical manifestations.
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